New index could prevent ventilator Over-Assistance in ICU patients

NCT ID NCT06921655

Recruiting now Knowledge-focused Sponsor: Centre for Medical Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a new measure called the Pressure-Muscle Index (PMI) can help doctors set ventilators more precisely for ICU patients with acute breathing failure. The goal is to avoid giving too much breathing support, which can harm the diaphragm and lungs. Thirty-six patients will try different ventilator settings to see if PMI can identify the right level of support.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Variation of Pressure Support Levels (procedure)
What this could lead to: If successful, this could lead to a simple bedside method to personalize ventilator settings, reducing lung and diaphragm damage in ICU patients.
What could go wrong: This is a small, early crossover study with only 36 participants, so results may not apply broadly. The PMI index is still experimental and needs further validation.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE HYPOXEMIC RESPIRATORY FAILURE MECHANICAL VENTILATION COMPLICATION

Contacts and locations

Locations

Santa Chiara Hospital, Trento, Trentino-Alto Adige, Italy
RECRUITING

Trento, Trento, 38122, Italy

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