Yale University

This study tested whether a medication called semaglutide (a GLP-1 analogue) could help people with obesity by reducing their cravings for tasty foods, lowering hunger, and decreasing stress. For 12 weeks, 96 participants received either the drug or a placebo (a dummy treatment) …

This Yale University study tested whether a combination of two existing medications (naltrexone and bupropion) could help people with binge-eating disorder and obesity. The trial specifically looked at patients who didn't respond well to initial treatments, comparing the medicati…

This study tested personalized approaches to help people living with HIV quit smoking. Researchers tried different combinations of nicotine replacement medications and cash rewards for not smoking. They followed 323 participants for 24 weeks to see which methods worked best at re…

This Yale University study tested whether a medication called lisdexamfetamine (LDX) could help people with binge-eating disorder and obesity maintain their progress after initial treatment. The Phase 3 trial involved 61 adults who had already responded well to earlier therapy. R…

This study tested a computer tool designed to help emergency room doctors follow best practices for treating opioid addiction. The tool guides doctors through diagnosing addiction, checking withdrawal symptoms, and starting a medication called buprenorphine. The goal is to see if…

This small pilot study tested whether a special telehealth platform could help people with serious opioid addiction get to their first treatment appointment. The program was designed for people who had survived at least one overdose. Researchers checked if using the platform made…

This study tested two different approaches to prevent tuberculosis (TB) in Malaysian prisons, where many inmates have opioid addiction, HIV, or hepatitis. Researchers compared a standard 40-week daily treatment against a shorter 12-week weekly treatment to see which worked better…

This small pilot study tested whether a daily online program with recovery videos was practical and helpful for people who drink heavily and want to change. Thirty adults in Connecticut used the web tool for 28 days and reported on their drinking and well-being. The main goal was…

This study tested a blood test to see if it could help doctors make sure patients with advanced breast cancer were getting the right amount of their main treatment drug. Researchers wanted to see if the test could spot when drug levels were too low, possibly due to missed doses o…

This study tested a new computer system designed to send alerts only to doctors whose hospitalized patients with sudden kidney injury were most likely to benefit. The goal was to prevent the kidney injury from getting worse, needing dialysis, or causing death, while reducing unne…

This study tested a new mobile app designed to help middle-aged adults with type 1 diabetes exercise more often and with more confidence. The app uses personal data like blood sugar levels, exercise, mood, and sleep to provide personalized encouragement and insights. Researchers …

This study tested a powerful four-drug chemotherapy regimen given both before and after surgery for patients with pancreatic cancer that had not spread. The goal was to shrink the tumor before surgery to make it easier to remove, and then kill any remaining cancer cells after sur…

This study looked at whether a very low-carbohydrate diet is a safe and effective way for young people with type 1 diabetes to manage their blood sugar. Nineteen teens and young adults tried both a low-carb and a standard diet for two weeks each while researchers tracked their gl…

This study tested whether a computer-based reminder system could help pediatricians better follow national guidelines for managing childhood overweight and obesity. It involved over 58,000 children across 81 primary care clinics. The goal was to see if these prompts improved the …

This study tested whether combining two existing cancer drugs, afatinib (a daily pill) and cetuximab (a weekly/bi-weekly IV infusion), could help control advanced head and neck cancer that had worsened after standard treatments. It involved 50 patients whose cancer had returned o…

This study tested a virtual reality video game designed to prevent middle school students from starting to vape e-cigarettes or cannabis. Researchers wanted to see if the game was practical for schools to use and if students found it engaging. They also measured whether playing t…

This study tested a suicide prevention program designed for mothers in rural Pakistan. Researchers wanted to see if this program could be successfully added to existing community mental health services. They worked with 50 women who were pregnant or had young children and were at…

This Yale University study tested a new therapy designed to prevent suicide in adolescents and young adults with depression or bipolar disorder. The therapy teaches self-help strategies to create more regular daily routines, especially for sleep, with the goal of improving brain …

This Yale University study tested a patient navigator program designed to help people with diabetes get regular eye exams to prevent blindness. The program focused on high-risk patients who hadn't had eye screenings in over a year. Researchers worked with 35 participants to see i…

This study tested whether giving pregnant Latina women money to buy fruits and vegetables, along with nutrition education, could improve their diets and reduce food insecurity. Researchers worked with 154 low-income women in Hartford, CT, providing monthly funds for produce over …

This study tested whether effective psychological treatment for children with serious oppositional, aggressive, or antisocial behavior could be delivered online. Researchers worked with 86 Connecticut families to see if internet-based therapy could reach families who might not ac…

This study tested whether online cognitive behavioral therapy is practical and acceptable for teenagers with bulimia nervosa who have higher weight. Twenty-five adolescents participated in 4 months of weekly telehealth sessions. The research aimed to see if this online approach c…

This Yale University study developed and tested a brief, self-guided program designed to increase hope in women experiencing intimate partner violence. The research team wanted to see if this single-session intervention was practical, safe, and well-liked by participants, and if …

This study tested a new device called Miraπ that physically moves a patient's weakened arm during mirror therapy, a common rehabilitation technique. Researchers compared this device to standard mirror therapy in 24 people recovering from a stroke in a hospital. The goal was to se…

This study tested whether giving a single dose of the medication olanzapine before surgery could improve how patients feel after going home. It focused on women aged 18-50 having outpatient surgery, as they are most likely to experience severe nausea and vomiting afterward. Resea…

This study tested whether repeated ketamine infusions could safely reduce depression in people with Parkinson's disease. Fifty-one participants were randomly assigned to receive either ketamine or a placebo infusion. Researchers also used brain scans on some participants to under…

This study tested if a numbing injection near the neck (a nerve block) helps people feel better after thyroid surgery. 160 patients were randomly given either the real numbing medicine or a harmless saltwater placebo before their operation. Researchers then compared how both grou…

This study tested whether a new portable device could help reduce muscle stiffness (spasticity) in the hands. Ten adults with hand paralysis or movement problems tried the device in a single 20-minute session at a Yale clinic. The device gently moved their fingers, and researcher…

This study tested whether a phone counseling program could help veterans with chronic pain and risky substance use. Over 1100 post-9/11 veterans applying for service-related compensation were randomly assigned to receive either the counseling calls or usual care. The counseling a…

This Yale University study tested whether an 8-week program of computer brain games could help reduce depression and improve thinking skills and quality of life. The study involved 36 people with major illnesses, specifically cancer survivors and patients with end-stage kidney di…

This study tested if a smaller-volume colonoscopy prep drink (MoviPrep) works as well as the standard large-volume drink (GoLYTELY) for patients already in the hospital. It involved 520 hospitalized adults to see if the smaller drink cleans the bowel effectively and is easier for…

This small, early study from Yale University tested whether the compound CBD (cannabidiol) could be safely added to treatment for people struggling with both opioid addiction and long-term pain. Seven participants who were already on stable medication for their addiction received…

This small pilot study tested whether an online guided self-help program is practical and acceptable for teenagers struggling with binge eating and higher weight. Eight teens aged 12-17 tried a four-month program with weekly online sessions. The main goal was to see if teens woul…

This Yale University study tested a new approach for people with severe temporal lobe epilepsy whose seizures can't be fully stopped by medications or surgery. Instead of trying to prevent seizures, researchers used a special brain stimulator to try to restore a patient's conscio…

This study aimed to find the best recovery time after a common surgery for stress urinary incontinence. Researchers compared whether 3 weeks or 6 weeks of activity restrictions (like avoiding heavy lifting) led to better patient outcomes and satisfaction. Over 200 women who had a…

This Yale University study aimed to understand how the brain recovers after people stop using cannabis. Researchers used brain scans and cognitive tests to measure changes in 162 participants—some with cannabis dependence and some healthy—over four weeks of abstinence. The goal w…

This study aims to understand how brain chemistry differs in people with depression, PTSD, and bipolar disorder. Researchers will use MRI and PET scans to measure specific brain chemicals in 180 participants, comparing those with the conditions to healthy volunteers. The goal is …

This study aimed to understand how different e-cigarette settings affect how fast and how much nicotine gets into a person's bloodstream. Researchers at Yale had 36 regular e-cigarette users try devices with different nicotine strengths and chemical forms, while taking frequent b…

This study aimed to understand why a common heart failure medication (Entresto/LCZ696) can sometimes cause a significant drop in blood pressure, which is a concern for doctors and patients. Researchers tested 46 stable heart failure patients to see if a natural body chemical call…

This small pilot study aimed to understand how adult e-cigarette users perceive the cooling sensation from different flavor ingredients. Researchers tested 31 adults who regularly use e-cigarettes, having them try e-liquids with varying concentrations of two cooling flavors (WS-3…

This Yale University study investigated whether a specific virtual reality program could create experiences similar to taking psychedelic drugs. Researchers enrolled 10 healthy volunteers to compare the virtual reality experience to the effects of standard psychedelic doses. The …

This study aimed to understand how an experimental drug called CVL-562 affects brain circuits involved in memory for people with early schizophrenia. Researchers gave 112 participants different doses of the drug and used MRI brain scans to measure activity while they performed me…

This study tested a new imaging method to see if it could measure blood flow in the feet. Researchers compared scans from 34 healthy people and patients with diabetes and clogged leg arteries. The goal was to see if this scan could show how well a procedure to open blocked arteri…

This Yale University study tested whether specific cognitive tasks and driving simulations can reliably detect marijuana impairment. Researchers gave 41 regular marijuana users either a placebo or high-THC marijuana, then measured their performance on memory tests and driving sim…

This Yale University study aimed to understand how short-term stress changes the way our brains learn and form memories. Researchers used brain scans (fMRI) and memory tests on 106 healthy adults to see how stress affects different learning pathways. The goal was to gather basic …

This Yale University study aimed to improve how doctors predict the progression of prostate cancer. Researchers analyzed individual cells from standard prostate biopsies taken from 600 men to look for detailed biological patterns. The goal was to find better ways to tell which ca…

This study tested a new strategy to find people exposed to tuberculosis (TB) in Colombia. Researchers used a mobile app (chatbot) to communicate with patients and their household contacts and collected oral swabs for testing instead of traditional sputum samples. The main goal wa…

This small Yale University study tested whether giving people a tiny, safe dose of a bacterial compound (endotoxin) would change how much alcohol they chose to drink in a lab setting. Researchers compared 27 adults with alcohol use disorder who received either the compound or a p…

This early research study aims to understand how giving chloride supplements without sodium affects people with stable heart failure. Researchers will closely monitor 20 hospitalized patients to see how chloride impacts their blood volume, kidney function, and body chemistry. The…

This study tested whether an AI tool could help community health workers in Nigeria provide better care. Researchers gave workers instant computer feedback on their patient notes and compared them to notes written without help. A doctor then reviewed all the notes to see if the A…

This Yale University study aimed to understand if men and women experience the flavors in e-cigarettes differently and how that affects how much they like them. The researchers had 66 adult smokers try three different flavored e-cigarettes with nicotine in a lab setting. They mea…

This Yale University study used brain imaging to understand how vitamin D might affect brain chemistry in people with opioid use disorder. Researchers compared brain scans from a small group of participants with the disorder to healthy volunteers after giving them either vitamin …

This study aimed to validate a set of tools to measure social function in children with autism spectrum disorder (ASD). Researchers tested 400 children, aged 6-11, with and without ASD, using brain wave recordings (EEG), eye-tracking, and behavior assessments over 24 weeks. The g…

This Yale University study aimed to see if learning about 'overdiagnosis'—when screening finds a cancer that wouldn't have caused harm—changes whether older women plan to get mammograms. Researchers surveyed 311 women aged 70 and older, asking them questions before and after watc…

This Yale University study aimed to understand the connection between gut bacteria, diet, and fat production in the liver during adolescence. Researchers studied 38 healthy teens and young adults to see if certain gut chemicals affect how the body makes fat and if a low-carb diet…

This Yale University study examined how different e-cigarette flavors affect adult smokers' experiences. Researchers had 130 smokers aged 21-50 try e-cigarettes with flavors like cherry, vanilla, menthol, and tobacco during lab sessions. Participants then switched to only using p…

This study aimed to understand how THC, the main active compound in cannabis, changes how immune cells work at a genetic level. Researchers gave THC to 56 people, some with HIV and some without, to measure changes in their genes and immune proteins. The goal was to gather basic k…

This study aimed to understand how to successfully introduce routine breast cancer screening exams in primary care clinics in Soweto, South Africa. Researchers worked with clinic staff, health officials, and local women to identify the main challenges and practical solutions. The…

This study aimed to understand why strokes often recur in people with hardened brain arteries, even with good treatment. Researchers used a special type of MRI scan with two different contrast agents to look for signs of inflammation in the artery walls of 30 stroke patients. The…