Hospital colonoscopy showdown: Low-Volume prep may be easier on patients
NCT ID NCT05054036
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a low-volume bowel prep (MoviPrep) works as well as a high-volume one (GoLYTELY) in hospitalized patients getting a colonoscopy. The goal was to see if the low-volume option is better tolerated while still cleaning the bowel adequately. 520 hospitalized adults took part, and the results could help make colonoscopy prep easier for sicker patients.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- MoviPrep (low-volume bowel preparation) and GoLYTELY (high-volume bowel preparation)
- What this could lead to
- If MoviPrep works better, hospitalized patients may have a more tolerable bowel prep option, potentially reducing delays and hospital stays.
- What could go wrong
- This is a completed Phase 4 trial, but results may not apply to all patients or settings. Tolerability and prep quality can vary individually.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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520 people
The number who actually took part.
- Started
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Jan 2022
- Finished
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Jul 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Male or female, aged 18 or greater 4. Hospitalized patient scheduled to undergo colonoscopy with bowel preparation (not including preparation with enemas alone) 5. Ability to take bowel preparation and be willing to adhere to the regimen Exclusion Criteria: 1. Patients presenting to the hospital with ileus, toxic megacolon, evidence of gastrointestinal obstruction 2. Receipt of bowel preparation for other reasons during their hospitalization prior to their colonoscopy 3. Patients with prior significant gastrointestinal surgeries including colonic resection, subtotal colectomy, abdomino-perineal resection, Hartmann's procedure or other similar surgeries involving structure/function of small intestine or colon 4. Unable to give informed consent to the procedure 5. Known glucose-6-phosphate dehydrogenase deficiency 6. Known phenylketonuria 7. Known hypersensitivity to polyethylene glycols or ascorbic acid 8. Patients undergoing colonoscopy for foreign body removal and/or decompression 9. Pregnancy or lactating women
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Bridgeport Hospital
Bridgeport, Connecticut, 06610, United States
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Yale New-Haven Hospital
New Haven, Connecticut, 06510, United States
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