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E-Cig coolant study seeks the perfect chill

NCT ID NCT05932693

Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed pilot study tested how different amounts of a coolant called WS-3 affect the sensation of e-cigarettes in 31 adult users. Participants tried various levels of WS-3 and rated the coolness, sweetness, and harshness. The goal was to find the right concentrations for future research.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
E-liquid coolant (WS-3)
What this could lead to
If successful, this study could help determine the right amount of coolant to use in e-cigarettes for a satisfying cooling sensation.
What could go wrong
This is a small, early pilot study with only 31 participants, so results may not apply to all e-cigarette users. It does not test health effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

31 people

The number who actually took part.

Started

Sep 2024

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years or older * Able to read and write * Used e-cigarettes containing nicotine * Use e-cigs in past 30 days * No strong dislike of the menthol flavor * Urine cotinine ≥200ng/ml * Willing to abstain from tobacco/nicotine use 2 hrs prior to sessions Exclusion Criteria: * Known hypersensitivity to propylene glycol * Pregnant or lactating females * Uncontrolled asthma * Nut/e-liquid flavorant allergy * Current marijuana (tetrahydrocannabinol) vaping + E-cigarette or vaping use Associated Lung Injury (EVALI) symptoms * Dislike of menthol flavor

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Conditions

The condition(s) this trial relates to.

Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

E-cig use

Contacts and locations

Locations

  • Yale School of Medicine

    New Haven, Connecticut, 06473, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.