Yale University

This study tests if empagliflozin, a diabetes drug, can reduce sugar absorption during peritoneal dialysis in 30 adults with end-stage kidney disease. Participants will receive either the drug or a placebo in a crossover design, followed by an 8-week open-label phase where everyo…

This small pilot study at Yale tests whether semaglutide (a drug used for diabetes and weight loss) can help people who have had bariatric surgery and now struggle with alcohol use disorder. Ten adults will take the drug for three months and be followed for three more months to s…

This study tests whether adding spironolactone to standard blood pressure treatment helps lower blood pressure more effectively in people who have had a stroke. About 160 adults who had a bleeding or clot-caused stroke are taking spironolactone or continuing their usual care. Res…

This trial tests whether combining ketamine with a week-long exposure therapy can help people with PTSD by enhancing memory reconsolidation and reducing overgeneralized fear. Adults aged 21-70 with PTSD will receive either ketamine or midazolam (a comparison drug) during therapy …

This phase 2 trial is investigating whether an experimental drug called NC318, given alone or combined with the immunotherapy pembrolizumab, can shrink tumors in people with advanced non-small cell lung cancer. The study includes patients whose cancer has progressed despite prior…

This study tests whether a low-caffeine green tea extract (EGCG) can shrink uterine fibroids and improve pregnancy and live birth rates in women aged 18-40 who have been trying to conceive for at least six months. Participants take the extract and are monitored for changes in fib…

This study compares using an electric breast pump (or hand stimulation) to standard oxytocin infusion for inducing labor in nearly 1,000 first-time mothers. The goal is to see if nipple stimulation leads to more spontaneous vaginal deliveries and better experiences for moms and b…

This study looks at whether surgically removing the prostate, along with hormone therapy and possibly chemotherapy, can help men whose prostate cancer has already spread. About 190 men with newly diagnosed stage IV prostate cancer will be randomly assigned to get either standard …

This study investigates whether empagliflozin, a drug typically used for diabetes, can help people with worsening heart failure get rid of extra fluid. Researchers will give 60 participants either empagliflozin or a placebo for six weeks, alongside their usual diuretic medication…

This study tests whether combining one-on-one financial coaching with access to safe, affordable banking services can improve both financial health and mental well-being for people recently released from jail or prison. Participants, who self-identify as having mental health or s…

This study tests a new way to help people with heart failure in Uganda manage their condition. It combines a standard care program with a mobile app that tracks symptoms and gives advice. The goal is to see if this approach improves self-care and reduces deaths or hospital stays.…

This early-phase study tested a new drug called BHV-7000 in 5 people with epilepsy who have a brain implant (RNS) that records brain activity. The goal was to see if the drug reduces abnormal electrical activity linked to seizures. Participants took the drug for 4 weeks, and thei…

This study tests a drug called sacituzumab govitecan in 50 people with endometrial cancer that has returned or not responded to platinum chemotherapy. The drug works by delivering chemotherapy directly to cancer cells. The main goal is to see how many patients' tumors shrink or d…

This study looks at ways to help people of color living in areas with high overdose rates start and continue medication-assisted treatment (MAT) for opioid or alcohol use. Researchers will track how many treatment sessions people attend and whether they stick with their medicatio…

This small pilot study tested whether propranolol, a beta blocker usually used for high blood pressure, can reduce alcohol drinking triggered by stress. Twenty adults with alcohol use disorder were randomly assigned to take propranolol or a placebo for about two weeks, then compl…

This Phase 3 trial tests whether taking Elagolix, a hormone-blocking drug, before IVF can increase live birth rates in women with endometriosis. About 97 women will receive either Elagolix or a placebo before their IVF cycle. The goal is to see if this pre-treatment improves the …

This study tests whether combining two approved drugs, belantamab mafodotin and elotuzumab, is safe and works better than either alone for multiple myeloma. About 24 adults whose cancer has returned or not responded to at least three prior treatments will receive the combination.…

This pilot study tests a web-based program called Let's Do Addiction Recovery Together! (LDART) for adults with alcohol use disorder. Participants use the website to set daily goals, watch motivational messages from people in recovery, and find local support groups. The study wil…

This pilot study tests a web-based program called LDART for adults with stimulant use disorder (cocaine or methamphetamine). The program includes daily goal setting, motivational messages from people in recovery, and links to support groups. Researchers want to see if it's feasib…

This early-phase trial tests a combination of two drugs (domvanalimab and zimberelimab) that aim to help the immune system fight glioblastoma, an aggressive brain cancer that has returned after initial treatment. About 46 participants will receive the drugs to check safety and se…

This study tests whether semaglutide (Wegovy), a once-weekly injection, can preserve the pancreas's ability to produce insulin and reduce liver fat in 60 obese youth with prediabetes or early type 2 diabetes and fatty liver disease. Participants receive either semaglutide or a pl…

This pilot study tests whether giving the smoking-cessation drug varenicline to people with HIV who also have alcohol use disorder is practical and safe. Thirty participants will receive the medication along with support from a pharmacist and psychiatrist. The goal is to see if t…

This study tests a drug called sacituzumab govitecan in 20 people with ovarian, fallopian tube, or primary peritoneal cancer that has stopped responding to platinum-based chemotherapy. The drug works like a guided missile, delivering chemotherapy directly to cancer cells. The mai…

This early-stage study tests whether a drug called apremilast can help people with Alcohol Use Disorder drink less alcohol. Ten adults will take the medicine and then have their drinking measured in a lab setting. The goal is to see if the drug reduces alcohol consumption, especi…

This study tests a pharmacist-led program to help women with HIV who also face social challenges like housing or food insecurity. The program supports switching from daily pills to a long-acting injectable medication (cabotegravir/rilpivirine) given every two months. The goal is …

This study compares two telemedicine approaches for people with chronic pain and opioid misuse. One program provides standard medication management via remote visits, while the other adds a 12-week self-help program with phone-based coaching. The goal is to see which approach bet…

This study was designed to test whether the drug etrasimod (VELSIPITY) could help reduce the need for steroids in cancer patients who develop diarrhea and colon inflammation from immune checkpoint inhibitors. It planned to enroll about 0 participants with advanced cancer who had …

This pilot study tests a community-academic partnership to help children with asthma in New Haven. It offers home visits from trained community health workers (Promotoras) and an online tool for doctors to guide asthma care. The goal is to see if this approach is feasible and can…

This study tests a two-step treatment for people with pancreatic cancer that hasn't spread but can't be removed by surgery. First, patients receive a stronger chemotherapy cocktail (modified FOLFIRINOX), followed by precise, high-dose radiation (SBRT). The goal is to see if this …

This early study tests whether brexanolone, a drug already approved for postpartum depression, can safely reduce stress-induced alcohol use in 25 adults with both PTSD and alcohol use disorder. Participants receive a continuous 20-hour IV infusion under medical supervision. The m…

This study follows 26 severely obese teenagers aged 14-19 who chose to have one of three weight loss surgeries: gastric band, sleeve gastrectomy, or gastric bypass. Researchers track weight, body fat, blood sugar, and vitamin levels over time to see which surgery is safest and mo…

This pilot study tests whether temporarily raising blood pressure with drugs like phenylephrine or norepinephrine can reduce brain damage in people having a major stroke. About 40 adults with large-vessel blockage strokes will receive the blood pressure boost during standard clot…

This study will test if artificial intelligence (AI) can spot a rare heart condition called ATTR-CM in people with heart failure. Researchers will use AI to analyze electrocardiograms (ECGs) and echocardiograms (Echo) from 150 adults. The AI's findings will be checked against a s…

This study is testing whether artificial intelligence can detect transthyretin amyloid cardiomyopathy (ATTR-CM), a serious and often underdiagnosed heart condition, earlier than usual. Researchers will use AI algorithms to analyze routine ECGs and heart ultrasounds from up to 1.5…

This study tests whether artificial intelligence (AI) can spot a serious heart valve condition called aortic stenosis using portable, non-invasive devices. Researchers will enroll 410 adults aged 70 and older during routine primary care visits. The goal is to see if AI-powered an…

This study aimed to test a computer algorithm that uses insurance claims data to identify people with ATTR amyloidosis, a rare disease that affects the heart and nerves. Researchers planned to check how well the algorithm worked by reviewing medical records. However, the study wa…

This study tests a 24-week program called CoMPASS that uses rewards (contingency management) and extra support to help people who inject drugs take PrEP consistently for HIV prevention. About 526 participants with opioid use disorder will be enrolled. Those who don't stick with P…

This study tests a virtual reality (VR) program designed to help 8th graders avoid e-cigarettes and manage their emotions. Researchers at Yale University will first gather feedback from students and school staff to shape the program, then test whether it is easy to use and accept…

This study is testing a new augmented reality (AR) video game called "No Time Wasted" to see if it can help teens aged 16-18 learn about alcohol risks and reduce dangerous drinking behaviors. Twenty high school students will play the game using an AR headset and answer surveys ab…

This study tests whether taking warm water sitz baths for 10 minutes each night for a week can reduce pain after pelvic organ prolapse repair. 112 women will be randomly assigned to sitz baths or standard care. The main goal is to measure pain intensity one week after surgery usi…

This study from Yale University will test whether listening to live music can reduce anxiety and improve brain activity in people with early Alzheimer's disease, dementia, or mild cognitive impairment, along with their caregivers. Sixty pairs (patient and caregiver) will attend b…

This study tests a 6-week mindfulness-based program designed to improve sleep and reduce stress in Black women with insomnia. Researchers will enroll 340 women and track changes in sleep quality, stress levels, and how acceptable and feasible the program is. The goal is to see if…

This study tests a digital mindfulness app called Calm Health in 26 adults with chronic kidney disease. Participants use the app for 6 weeks while wearing a wrist sensor to track sleep, activity, and heart rate. The goal is to see if the app is easy to use and if it helps reduce …

This study is testing whether giving cancer patients in Maine free, medically tailored groceries plus nutrition counseling can improve their diet and well-being. One hundred adults with any stage or type of cancer will be split into three groups: one gets groceries and counseling…

This study tests whether a noninvasive technique called repetitive transcranial magnetic stimulation (rTMS) can reduce irritability by targeting brain circuits involved in frustration. About 20 adults with elevated irritability will receive rTMS while researchers measure brain ac…

This study tests a new method called Strategic Treatment Assessment for Youth (STAY) designed to help racial and ethnic minority teens with depression or suicidal thoughts stay in therapy. Researchers will compare STAY to standard care in 140 teens aged 12-18 across three communi…

This study looks at whether a 60-day nerve stimulation device placed near the back of the head can help people with stubborn headaches. Researchers will track pain levels, daily function, and how often participants need emergency care. About 300 adults with various headache types…

This early-stage study is testing whether repeated doses of psilocybin, the active ingredient in magic mushrooms, can reduce symptoms of obsessive-compulsive disorder (OCD). Twenty-eight adults with moderate-to-severe OCD who have not responded to standard treatments will receive…

This study planned to see if using virtual reality (VR) before a brain stimulation treatment called TMS could help people with OCD feel more comfortable. It was designed for adults already approved for TMS. However, the study was withdrawn before any participants were enrolled, s…

This small pilot study at Yale University is testing a modified form of cognitive-behavioral therapy (CBT) for children with autism and intellectual disability who struggle with irritability, tantrums, and aggression. Up to 6 children aged with an IQ between 55 and 85 will receiv…

This study tests a 24-week program called SC-POWR for 204 adults with opioid use disorder and chronic pain. Participants get medication, therapy, exercise (like Wii Fit and Tai Chi), and stress reduction (relaxation training and acupuncture). The goal is to reduce pain interferen…

This study looks at whether applying a silicone ointment to the skin before head and neck surgery helps wounds heal with less scarring. About 60 adults having non-emergency surgery will take part. Researchers will compare scars using standard rating scales and also track hospital…

This pilot study tests a tool called ED-TREAT that helps emergency room staff spot and treat agitation early. The goal is to see if the tool is easy to use and can reduce the need for physical restraints. The study involves 26 adults at Yale New Haven Hospital, but enrollment is …

This study planned to test whether a small electrical device (TENS) could reduce pain when placing an IUD. It was designed for adults getting a new or replacement IUD. The study was withdrawn before enrolling anyone, so no results are available.

This study looks at whether joining community drum circles and mindfulness programs can help reduce anxiety and depression in Black and other marginalized groups who faced extra stress during COVID-19. About 90 people aged 16 and older will take part. Researchers will measure how…

This study tests whether a virtual, community-based program combining music and mindfulness can help reduce stress, anxiety, and depression in people of African descent. About 300 participants aged 16 and older will take part. The goal is to see if these culturally relevant activ…

This study aimed to see if Botulinum Toxin-A (Botox) could help people with hidradenitis suppurativa, a painful skin condition. It planned to enroll adults with active armpit lesions of similar severity on both sides. However, the study was withdrawn before any participants were …

This small pilot study tests whether psilocybin, the active ingredient in magic mushrooms, can change brain connections to improve depression. 18 adults with major depression who didn't get better with standard treatments will receive psilocybin. Researchers will measure brain ac…

This study tests whether the UpRight Go posture trainer, a wearable device that vibrates when you slouch, can reduce pain, numbness, and weakness in people with cubital tunnel syndrome who haven't had surgery. Researchers at Yale University plan to enroll 40 adults and track symp…

Researchers are testing a coaching program to help primary care clinics in rural West Virginia screen and treat opioid use disorder, HIV, and hepatitis C. The program includes group priority-setting, rapid-cycle improvement coaching, and provider training. Twenty clinics will tak…

This study looks at whether a 12-session parenting program can change brain activity in mothers recovering from opioid use disorder. Researchers will use EEG to measure brain responses to baby faces and cries before and after the program. The goal is to see if supporting the moth…

This study looks at 500 women with chest pain to compare two tests used during heart catheterization—FFR and iFR—to see which better predicts future heart problems like heart attacks or strokes. Participants will be followed for 5 years. The goal is to improve how doctors decide …

This study looks at why standard heart failure medications may not fully block a hormone called aldosterone. Researchers will give 20 adults with stable heart failure either a placebo or the drug spironolactone, then measure how the body handles salt and water. The goal is to und…

This study uses PET scans with a special tracer to measure brain synapse density in 80 people—some with cocaine use disorder and some healthy controls. Researchers aim to see if cocaine changes brain connections, especially in areas linked to decision-making and addiction. Partic…

This study looks at whether giving doctors feedback about their prescribing habits can reduce the number of potentially harmful medications given to older adults when they leave the emergency department. About 200 clinicians from Yale New Haven Health System are taking part. The …

This study aims to measure heart and metabolic risk markers—such as insulin resistance and fat distribution—in young adults aged 18 to 30 with type 1 diabetes and a body mass index under 25. Researchers will track changes over one year using glucose clamps and meal tests. The goa…

This study explores whether the immune system plays a role in starting and driving Parkinson's disease. Researchers will collect blood, spinal fluid, stool, and saliva from people with REM sleep behavior disorder (a strong early sign of Parkinson's), people already diagnosed with…

This study tests whether a video or a written guide helps women aged 75 and older make better decisions about breast cancer screening. About 300 women who have had screening before but never had breast cancer will take an online survey. The goal is to see which format reduces con…

This study uses PET and MRI scans to measure brain cell connections in people with major depression or PTSD. Researchers will give ketamine to see if it can reverse synaptic loss linked to these conditions. The goal is to understand brain changes, not to provide treatment. About …

This study looks at how a new, more sensitive type of PET scan (PSMA PET) affects the anxiety, decision-making, and quality of life of 350 men with prostate cancer. Participants will fill out surveys about their feelings and experiences over a year. The goal is to understand the …

This study looks at whether a family-centered approach helps caregivers affected by intimate partner violence (IPV) engage more with support services compared to a child-centered approach. About 95 caregivers with children under 5 who were reported to child protective services fo…

This study aimed to see how MDMA changes brain activity in people with PTSD, especially in areas that handle emotions. Researchers planned to give MDMA to a small group and measure brain scans and PTSD symptoms. However, the study was withdrawn before any participants were enroll…

This study will enroll 210 adults aged 65 and older with early aortic stenosis (a heart valve narrowing) to see if an artificial intelligence tool can better predict how fast the disease worsens. Participants will have standard echocardiograms, and researchers will compare the AI…

This study looks at how small amounts of alcohol and THC (the active part of cannabis) affect driving in a simulator. Forty adults aged 21 to 55 who have used both substances before will take part. The goal is to understand how these drugs change driving performance and thinking,…

This study looks at how alcohol and cannabis, alone or together, affect driving ability and thinking. About 40 occasional cannabis users who also drink alcohol will use a driving simulator after taking controlled doses. The goal is to understand the risks of driving under the inf…

This observational study at Yale uses PET brain scans to measure CB1 receptor availability in 15 people who currently use synthetic cannabinoids. Researchers want to see if these receptors are lower in users and how that relates to thinking skills and brain rhythms during withdra…

This study looks at how alcohol and cannabis, alone or together, affect driving and thinking. About 40 occasional users aged 21–55 will take part. They will inhale low-dose THC (like a quarter of a joint) and drink alcohol, then test their driving on a simulator and complete ques…

This study at Yale University looks at how THC, the active ingredient in cannabis, affects short-term and long-term memory. Researchers will give 80 adults who have used cannabis before either a low dose of THC or a placebo and then test their memory. The goal is to better unders…

This study looks at how alcohol and cannabis, alone or together, affect driving ability and thinking. About 40 adults aged 21–55 who have used both substances before will take part. They will complete simulated driving tests and questionnaires after receiving the substances. The …

This study looks at whether a program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) can help adult education students with behavioral health issues like depression, anxiety, and substance use. About 340 students and staff from New Haven Adult Education w…

This study aims to uncover the genetic roots of aortic aneurysms and valve disease by analyzing tissue and blood samples from 3,000 participants. Researchers will look for new disease-causing genes and factors that affect disease severity. The goal is to build a biorepository to …

This study explores whether listening to recordings of communal drumming, combined with mindfulness, can reduce stress and improve mental health in People of African Descent. Researchers will measure feelings of connection and synchrony in 30 adults. The goal is to see if cultura…

This study tests whether a non-invasive brain stimulation technique called repetitive Transcranial Magnetic Stimulation (rTMS) can change how adults with autism process social information. Researchers will measure brain responses with EEG and eye-tracking before and after stimula…

This study involves 500 people who have chest pain or other signs of heart trouble, but whose main heart arteries are not blocked. Researchers use special tools during a heart catheterization to measure tiny blood vessel function and look for hidden causes like microvascular dise…

This study aimed to see if a simple blood test could find blockages in the small blood vessels of the heart in people who have had a heart transplant. Participants would have had blood draws every three months for a year, and their medical records would have been reviewed for thr…

This study looks at how cannabis (specifically the drug Dronabinol) changes the immune system and genes in people with HIV. Researchers will take blood samples before and after giving Dronabinol to 160 participants. The goal is to understand these changes better, which could help…

This study gathers information from 8,000 stroke patients worldwide to learn more about seizures that happen after a stroke. Researchers will analyze the data to see how well patients recover and to create a tool that can predict who might develop epilepsy. The goal is to improve…

This study is collecting information from 458 people with critical limb-threatening ischemia, a severe form of peripheral artery disease that can lead to amputation. The goal is to learn how different treatments affect patients' daily lives and health outcomes. Researchers hope t…

This study was designed to test whether a guided reflective writing program could reduce burnout in physician assistant students at Yale. The plan was to have students attend three 75-minute writing workshops and measure changes in burnout using a standard questionnaire. However,…