Nyu Langone Health

This study tests whether the shingles vaccine is safe and works well for people with lupus, a condition that weakens the immune system. About 224 adults with lupus will receive either the vaccine or a placebo to see if it causes lupus flare-ups. The goal is to confirm the vaccine…

This study compares e-cigarettes to standard nicotine replacement therapy (like patches) combined with counseling, to see which helps smokers with opioid use disorder cut down or quit regular cigarettes. About 300 adults in methadone or buprenorphine treatment programs will take …

This study tests a treatment for people whose stem cell transplant (from a donor) isn't working well, causing low blood cell counts. Researchers will give a special dose of donor cells to help the body make enough white blood cells and platelets. The goal is to improve blood coun…

This study looks at men with unfavorable intermediate-risk prostate cancer. Participants choose to receive either standard care (6 months of hormone therapy plus precise radiation) or radiation alone. The goal is to see if skipping hormone therapy still keeps cancer from coming b…

This early-stage study tests whether a drug called CpG 1018, which stimulates the body's natural immune system, is safe for people with mild cognitive impairment or mild Alzheimer's dementia. About 39 participants will receive one of three doses or a placebo over 8 weeks. The mai…

This early-phase study tests whether adding a heat-based treatment (radiofrequency ablation) to standard chemotherapy is safe for people with advanced pancreatic cancer that hasn't spread to other organs. About 15 participants will receive the procedure through an endoscope. The …

This study compares standard ACL reconstruction surgery to the same surgery with an added internal brace. The goal is to see if the brace helps the knee heal more stably. Researchers will measure knee looseness, function, and patient feedback over time. About 90 people aged 18 to…

This study tests whether combining remote blood pressure monitoring with support from community health workers helps Latinx patients better control their high blood pressure. About 300 adults who have trouble keeping their blood pressure under control will take part. The goal is …

This study is following 300 men with early-stage prostate cancer who choose to be treated with high-intensity focused ultrasound (HIFU). The goal is to track how well the treatment controls cancer and what side effects occur, especially regarding urinary and sexual function. Rese…

This study looks at whether giving nutritional supplements to patients who are malnourished before hip or knee replacement surgery can improve their blood markers of nutrition. About 72 adults aged 55-95 with osteoarthritis will take part. Researchers will measure key blood level…

This study tests a highly precise radiation therapy for men with intermediate-risk prostate cancer. Using real-time MRI guidance, doctors deliver a stronger radiation dose to the main tumor while giving a lower dose to the rest of the prostate. The goal is to improve tumor contro…

This study is testing an auditory brainstem implant (ABI) in up to 20 children who are deaf because they are missing their inner ear or hearing nerve. The implant sends sound signals directly to the brainstem, bypassing the ear. Researchers will monitor safety and measure how wel…

This study tests two ways to help Chinese immigrants in New York City better manage their type 2 diabetes. One group gets educational videos, another gets videos plus a community health worker, and a third group gets usual care. The goal is to see if these approaches lower blood …

This study is for people with HPV-positive throat cancer. It tests whether doctors can safely lower the radiation dose during treatment if the tumor shrinks quickly and a blood test shows the cancer virus is clearing. The goal is to see if a lower dose still prevents the cancer f…

This study looks at whether using portable air cleaners at home can lower blood pressure in adults with hypertension living in New York City public housing. Air pollution is a known risk factor for heart disease, and this approach aims to reduce exposure to tiny particles in the …

This study looks at whether time-restricted eating (eating only during a set window each day) can help adults who have recently lost weight keep it off and avoid regaining fat. About 110 adults aged 25 to 65 who lost at least 5% of their body weight in the last 3 months will be r…

This study tests whether belatacept, an anti-rejection medication, is safe for adults who receive a heart transplant. About 12 participants will receive belatacept to prevent organ rejection. The goal is to see if it reduces serious complications like rejection, infection, or gra…

This study looks at whether wearing a continuous glucose monitor (CGM) for two weeks after starting insulin in the hospital helps manage blood sugar better than standard finger-stick testing. About 150 adults with type 1 or type 2 diabetes who are new to insulin will be randomly …

This study tests whether a collaborative care model—where primary care providers work with a care team—can help adults reduce their use of opioids, stimulants (like cocaine or methamphetamine), and heavy alcohol. About 350 participants with moderate to severe substance use disord…

This study tests whether having trained peers deliver blood pressure medications directly to patients' homes, combined with health technology, can help people take their pills more regularly and lower their blood pressure. About 1,140 adults with uncontrolled high blood pressure …

This study is testing whether empagliflozin, a drug used for diabetes, is safe and helpful for people who have just started hemodialysis for end-stage kidney disease. About 60 adults will receive either the drug or a placebo for 12 weeks. Researchers will measure changes in body …

This study aims to see if a modified MRI technique can reduce the distortion caused by metal hip implants, giving clearer images. About 22 adults with a painful hip replacement will get both a standard and a modified MRI. The goal is to help doctors see the area around the implan…

This study tests a program called Mom♥Health that helps mothers of young children reduce their risk of heart disease. About 40 women who have a child aged 5 or younger will receive support to manage stress and connect with health services. The goal is to see if this approach is p…

This study is testing a mobile phone toolkit called mWEL to help teachers and caregivers in Uganda improve their mental health and prevent depression and anxiety. About 1180 participants will use the app, with some also getting support from community health workers. The goal is t…

This study tests whether a behavioral program (exercises and strategies) started one week before neck surgery and continued for six weeks after can improve swallowing and voice. Fifty adults having anterior cervical discectomy and fusion (ACDF) will participate. They will have sw…

This study tests a light therapy called transcranial photobiomodulation (tPBM) in 70 older adults (ages 55-85) who had a moderate or severe traumatic brain injury 1-2 years ago. The goal is to see if shining light on the head can increase blood flow to the brain and improve think…

This study tests whether Jornay PM, a medication taken at night, can help control ADHD symptoms in adults throughout the next day. Researchers will enroll 30 adults aged 18-60 with ADHD to see how well the drug works and if it is safe. The goal is to gather first-time data on how…

This study tests a 3-month mobile health cardiac rehab program for 250 adults who have chest pain or other symptoms of heart ischemia but no blocked arteries (INOCA). Participants will either use a smartphone app with activity tracking, weekly coaching, and exercise logging, or r…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce anxiety, depression, and fear of death in people with advanced cancer. About 200 adults with stage 3 or 4 cancer will receive either psilocybin or…

This study tests whether a device that sends mild electrical pulses to the calf muscle can help people regain strength and movement after ankle fracture surgery. Twenty adults will be randomly assigned to receive either standard physical therapy alone or physical therapy plus the…

This study tests whether a smartphone app called SilverCloud, which teaches cognitive behavioral therapy skills, can help high school students with depression or anxiety. About 120 teens who screen positive for symptoms will either use the app with a clinician's guidance or recei…

This study tests whether empagliflozin, a medication used for diabetes, can ease symptoms of major depression. The drug may help the brain use an alternative energy source called ketones. Researchers will enroll 16 adults with moderate to severe depression to see if their mood im…

This study tests a virtual program that teaches mindfulness, exercise, and healthy eating to adults who had a traumatic brain injury at least a year ago. The goal is to see if it helps with emotional well-being, physical health, and nutrition. About 138 participants will be rando…

This study is testing a new noise reduction algorithm designed to help cochlear implant users understand speech better in noisy environments. Researchers will compare how well participants recognize words with and without the algorithm in both quiet and noisy settings. The study …

This study tests a program called RELAXaHEAD that uses behavioral techniques to help people manage migraines from home. About 356 adults with migraines will use the program for 6 weeks. The goal is to see if it reduces disability and improves quality of life.

This study tests whether shining a special invisible light on the forehead can change blood flow in the brains of people with major depression. Researchers will measure brain activity and mood changes in 120 adults aged 18-65. The goal is to see if this simple, non-invasive appro…

This study tests whether a telephone-based mindfulness program can help Black women with high blood pressure lower their blood pressure and reduce stress. About 300 women from the Jackson Heart Study will join either a mindfulness group or a support group over Zoom. The goal is t…

This study is testing whether a program that includes a Fitbit smartwatch, motivational text messages, educational videos, and virtual physical therapy can help older adults (with or without mild dementia) become more active. About 100 older adults and their care partners will ta…

This study tests whether using a special cuff that limits blood flow during exercise can help people with leg tendon or bone injuries regain strength and muscle mass faster. About 128 adults aged 18 to 65 who are getting physical therapy will be randomly assigned to receive eithe…

This study tests whether a gentle brain stimulation technique (tDCS) combined with speech therapy can reduce stuttering severity and its negative impact on daily life. Researchers will enroll 16 adults who stutter to receive the combined treatment and measure changes in speech fl…

This study tests whether a special light therapy (called photobiomodulation or PBM) can reduce swelling and scarring caused by radiation treatment in head and neck cancer patients. About 60 people who completed radiation at least 3 months ago will be randomly assigned to receive …

This pilot study tests whether a special finger splint called a Relative Motion Orthosis (RMO) helps people regain finger movement after an injury better than standard care alone. About 64 adults with stiff finger joints will be randomly assigned to receive either standard therap…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can change brain activity and reduce drinking in 200 adults with alcohol use disorder. Participants receive either psilocybin or a placebo in a controlled setting, and researchers use brain scans to me…

This study looks at how a part of the brain called the hippocampus behaves when people with epilepsy look around and explore. Researchers will monitor brain activity while participants do simple visual tasks, like looking at pictures or dots. No new treatment is being tested—the …

This study works with community partners and NYC public hospitals to help people with limited English get better language services and preventive care. Researchers will develop and test a health literacy program with 17,500 participants. The goal is to increase use of interpreter…

This study collects medical records, family histories, and DNA from children aged 11 months to 18 years who died suddenly and without a clear cause. Researchers hope to identify risk factors and causes to prevent future deaths. Up to 1,600 participants will be enrolled.

This study aims to help people with small kidney tumors (up to 4 cm) make better treatment decisions. Researchers will create a decision aid that explains the benefits and risks of each option based on the patient's own situation. About 40 adults will use the tool and then answer…

This study is testing whether offering low-cost, culturally-adapted fresh produce boxes to immigrant communities in Brooklyn can improve their diet and sense of belonging. About 3,200 adults who speak English, Chinese, Spanish, or Bangla will receive the boxes along with nutritio…

This study looks at platelets—tiny blood cells involved in clotting—in people who have had a heart attack. Researchers will compare samples from 350 men and women, including those with and without blocked arteries, to find differences that may explain why heart attacks happen. Th…

This study explores whether heart rate measurements can improve a brain stimulation technique called tDCS for people with mild to moderate depression. One hundred adults will use a headset at home for 10 days, receiving either real or sham stimulation. The goal is to find a simpl…

This study follows people with familial dysautonomia (FD), a rare nerve disorder, to collect health information and blood samples over time. Researchers will build a database of symptoms and test results to better understand the disease and find biological markers. The goal is to…

This study looks at different ways communities respond to crises—like sending mental health workers instead of police—to see if they reduce violence among young people. Researchers will study 15 U.S. cities that use these models and compare crime rates before and after they start…

This study looks back at 2,000 patients who had surgery for a type of pancreatic cyst called IPMN. Researchers want to understand why surgery was done and how often these cysts were linked to hidden pancreatic cancer. The goal is to help doctors better predict which cysts are dan…

This study looks at how harm reduction programs in New York City homeless shelters affect overdose deaths and health care use. Researchers will analyze data from up to 80 people who stayed in shelters between 2021 and 2026. The goal is to understand if these programs help reduce …

This study looks at whether a digital visual communication tool can help newly diagnosed cancer patients (breast or head and neck) better understand their treatment options. About 86 patients and their caregivers will use the tool and then rate their satisfaction. The goal is to …

This study looks at ways to help parents of children with multiple health conditions or technology needs care for them after leaving the hospital. The goal is to reduce problems like readmissions or medication errors. About 282 parents will be surveyed about how well they underst…

This study aims to understand how the trillions of bacteria living in our bodies (the microbiome) influence health and disease, especially cancer and heart disease. Researchers at NYU will collect samples and health information from 16,000 adults over 40 over time. The goal is to…

This study looks at how to expand a mental health program for teachers and students in Ugandan schools. Researchers will train some teachers to become trainers themselves, using both in-person and digital methods. The goal is to see if this approach can help more teachers learn h…

This study looks at why people struggle with self-control, especially around tempting foods. Researchers will ask 300 adults on a diet how much they would pay to avoid seeing tempting snacks, while also scanning their brains. The goal is to understand the mental and brain process…

This study looks at the bacteria living in the lungs of people with a chronic lung condition called bronchiectasis who may also have an NTM infection. Researchers will collect sputum and airway samples from 200 participants to compare the bacteria in those with and without active…

This study tests whether a culturally and language-specific education program can help more people get screened for colorectal cancer. About 50 adults aged 45-75 who are not up-to-date with screening will take part. The program aims to improve understanding and encourage completi…

This study looks at how breathing in dust from the World Trade Center collapse may cause heart and lung problems in FDNY rescue workers. Researchers will measure certain substances in the blood and breathing tests to find early signs of disease. About 100 retired or light-duty fi…

This small study tests a device that gently stimulates a nerve in the ear (vagus nerve) in 20 adults with chronic kidney disease. The goal is to see if the device is safe, tolerable, and affects heart rate variability, which is linked to heart health. Results will help design a l…

This study works with the Ramapough Nation to understand how environmental pollution and diet affect their health. Researchers will test soil, water, and blood samples for heavy metals and nutrients, and collect health information from 400 adults. The goal is to support tradition…

This study creates a registry of 500 adults diagnosed with takotsubo (broken heart) syndrome. Researchers will follow participants over time to track heart events, quality of life, and stress. The goal is to better understand what causes this heart condition and to plan future st…

This study is testing a non-invasive light sensor (NIRS) to see if it can detect kidney injury earlier in very premature babies (born before 30 weeks). Researchers will monitor oxygen levels in the kidneys over the first week of life and track other health outcomes. The goal is t…

This study is looking for biological markers (biomarkers) in blood and airway samples that can show whether phage therapy is working against hard-to-treat bacterial lung infections. Researchers will compare samples from 100 adults who receive phage therapy with those who do not. …

This study looks at 48 adults with advanced lung cancer who are starting immunotherapy. Researchers collect samples from the lungs, stool, and blood to see if the natural bacteria in these areas can predict how well the treatment works. The goal is to understand why some people r…

This study aims to understand how the brain generates the sense of wanting to move. Researchers will use non-invasive brain stimulation and brain scans to compare healthy volunteers and people with psychogenic movement disorders or non-epileptic seizures. The goal is to gather kn…

This study looks at how social media ads affect the food choices of Black and White teenagers aged 13 to 17. Researchers will measure how many calories teens buy or eat after seeing different ads, and track where they look on the screen. The goal is to understand how ads and onli…

This study compares the types of bacteria and inflammation in the lungs of smokers who have early-stage COPD versus those with normal lung function. Researchers will collect fluid from the lungs to analyze bacterial activity and immune responses. The goal is to better understand …