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9/11 dust linked to heart and lung damage: new study seeks answers

NCT ID NCT05215171

Knowledge-focused Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how breathing in dust from the World Trade Center attacks may harm the heart and lungs of FDNY first responders. Researchers will measure certain substances in the blood and breathing tests to find early signs of disease. The goal is to better understand these health problems so doctors can diagnose and treat them sooner. About 100 retired or light-duty firefighters will take part.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2023

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Both Male and female subjects 21-90 year old will be enrolled. FDNY WTC exposed 1st responders enrolled in the WTC-Health Program.

Ages

21 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 21-90 2. FDNY rescue and recovery worker 3. Documented WTC exposure 4. Consented/Enrolled member of the WTC-HP 5. Subjects are willing and able to consent for themselves to study enrollment 6. Subjects are willing and able to participate in study procedures 7. Are able to perform their activities of daily living independently 8. Are either light duty or retired FDNY Firefighters 9. Spirometry available within the last 24 months, and at a post-9/11 visit. 10. Have means to accommodate transportation to/from in-person visit Are able to attend a single visit at the CTSI (462 1st Avenue, C \& D 4th Floor) 11. Pre-9/11 spirometry with FEV1%predicted ≥LLN and if not available 1st -post 9/11 spirometry with an FEV1 \>80% predicted. 12. No recorded positive AHR testing prior to 9/11 13. Exposure at the WTC-site within 2 weeks of 9/11/2001 14. Entered WTC-HP before the site closure on 7/24/2002 15. Serum from their first post 9/11 WTC-HP visit is available in the biorepository and may be assayed 16. Are not currently being treated for malignancy 17. Subjects will either need to be defined as having WTC-AHR or be designated controls Exclusion Criteria: 1. Unwilling to complete an informed consent. 2. Not enrolled in the WTC-HP 3. Do not meet eligibility criteria or did not have serum available in the biorepository from the first post 9/11 WTC-HP visit. 4. Have pre-existing and documented conditions or concurrent diagnoses, including (and not necessarily limited to) active cancer, severe heart disease, significant cognitive impairment, eating disorders, significant psychiatric illness, end-stage COPD, severe pulmonary hypertension, or organ transplant. 5. High dose steroid (\>20mg prednisone or equivalent) or other hormonal treatments/chemotherapy use in the last month, including testosterone supplementation. 6. Life-expectancy \< 6 months

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Conditions

The condition(s) this trial relates to.

obstructive lung disease reactive airway disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiorespiratory and vascular dysfunction Obstructive airway disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • NYU Clinical & Translational Science Institute Clinical Research Center (CTSI CRC)

    RECRUITING

    New York, New York, 10016, United States

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Other studies related to the condition(s) this trial covers.