Vertebral column disorder

This study is testing a material called Orthoss®, made from granules, to help bones in the spine fuse together after surgery. The trial includes 65 adults with lower back problems like slipped discs or narrowing of the spine canal. Doctors will check if the bones fuse properly an…

This study tests a device called a motor neuroprosthesis, an implantable brain computer interface designed to help people with severe paralysis control digital devices like computers or tablets. The device aims to bypass damaged motor pathways and transmit brain signals directly …

This trial tests whether nutrition counseling delivered over video calls can help people with spinal cord injury eat healthier and lower their risk of obesity, high cholesterol, and diabetes. Participants, who are at least one year post-injury and overweight, will receive six ses…

This study tests a new gel, MegaShield-SP, to see if it prevents scar tissue after spine surgery better than an existing gel. About 80 adults aged 20-70 with a herniated disc or spinal stenosis will receive one of the two gels during surgery. Researchers will measure scar formati…

This study is testing a new spinal implant called the DEXA-C, which is designed to match a patient's bone density scan to improve fusion after cervical disc surgery. About 80 adults with degenerative disc disease and arm symptoms will receive the implant and be followed for 12 mo…

This trial tests whether a brain-computer interface (BCI) can guide electrical stimulation to improve leg muscle activation and walking in people with spinal cord injury. Participants imagine moving their ankles while a device reads their brain signals and triggers electrical sti…

This study tests whether the drug ixekizumab is safe and effective for children with certain types of juvenile arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). About 101 children aged 2 to 17 years will receive either ixekizumab or the standard drug adal…

This study looks at whether doing blood flow-restricted exercise two or three times per week makes a difference in muscle strength recovery for people with incomplete cervical spinal cord injury. Participants perform low-load muscle contractions while a cuff partially restricts b…

This study tests a device that reads brain signals and sends them to the spinal cord to help people with chronic spinal cord injury move their legs. Three participants will use the system during rehabilitation to see if it is safe and can improve walking. The goal is to create a …

This trial tests whether a focused form of brain stimulation called high-definition transcranial direct current stimulation (HD-tDCS) can improve arm and hand function in people with cervical spinal cord injury. Participants receive either HD-tDCS or conventional stimulation duri…

This study looks at whether a drug called abaloparatide can improve bone quality in people with osteoporosis who need spine surgery. About 60 participants will take the drug for 3-6 months before and after surgery. The goal is to see if it reduces complications like broken hardwa…

This trial tests a procedure called expansile duraplasty, where surgeons open the spinal cord's covering and sew in a patch to give the swollen cord more room. Researchers will compare recovery in 66 adults who receive this extra surgery versus those who get standard care alone. …

This trial compares two surgical techniques for treating cervical degenerative disc disease: using a stand-alone cage versus a cage-screw fixation system. Both aim to relieve pain and improve function by removing the damaged disc and fusing the vertebrae. The study measures pain …

This study tests whether short, mild low-oxygen breathing sessions can improve walking and leg strength in people with a recent spinal cord injury. Over 10 sessions, participants breathe either low-oxygen air or normal air through a mask. The goal is to see if this simple approac…

This study tests whether a short, standardized 4-minute heart-healthy talk is as effective as a full 60-minute personalized session with a dietitian for lowering LDL cholesterol and improving diet. Participants are adults aged 30–80 with rheumatoid arthritis, psoriatic arthritis,…

This study evaluates a free, student-run occupational therapy clinic for uninsured or under-insured adults with spinal cord injury or disease. Participants attend group sessions and one-on-one therapy covering bowel/bladder management, community mobility, and advocacy. Researcher…

This study tests whether combining spinal cord stimulation with electrical muscle stimulation can improve cough strength in people who recently had a spinal cord injury. Participants will receive either real or sham stimulation during cough training sessions over several weeks. T…

This trial investigates how different amounts of robotic gait training using an exoskeleton, combined with brain stimulation, affect walking ability in people with spinal cord injury. Participants with motor incomplete injuries will train during inpatient and outpatient rehab. Th…

This study tests a new artificial disc called the Synergy Disc for people with two-level cervical degenerative disc disease (DDD) who haven't improved with non-surgical care. The disc is designed to replace damaged discs in the neck while preserving motion, unlike standard fusion…

This study tests a surgical technique to restore the natural curve (lordosis) of the lower spine in people who have had a previous spinal fusion that failed or caused ongoing pain. The procedure is done through the same incision used in the prior surgery. Researchers will measure…

This study compares two types of implants used in spinal fusion surgery: 3D-printed cages and titanium-coated cages. The goal is to see which leads to better bone fusion and less disability for patients with herniated discs or degenerative spine disease. About 78 adults undergoin…

This study follows 176 adults aged 21-80 who are already scheduled for a single-level lower back fusion surgery using screws and cages. The goal is to collect real-world data on pain, mobility, and safety over 24 months. It does not test a new treatment but observes standard care…

This early-stage trial tests whether injections of tiny particles from umbilical cord stem cells are safe for people with syringomyelia, a condition where fluid-filled cavities form in the spinal cord. The study will enroll 18 adults whose symptoms haven't improved after surgery …

This study tests a new device called MOTUS, which replaces a worn-out joint in the lower back with an artificial one. The goal is to see if it works as well as the standard surgery (spinal fusion) for reducing pain and improving function. About 158 adults aged 21-80 with single-l…

This study tests whether a robotic exoskeleton called ReWalk can help people with complete spinal cord injury below T4 walk and improve their health. Fifty participants will either use the exoskeleton or receive standard physical therapy. The goal is to see if the device improves…

This study tests a precise type of proton radiation (IMPT) for people with chordoma or chondrosarcoma in the spine, sacrum, or skull base. The goal is to control the tumor while reducing damage to healthy tissue. Some participants may also have surgery. The study includes 64 adul…

This study tests whether nerve transfer surgery can improve arm and hand function in people with complete spinal cord injuries who have no hand movement. Seventy participants will undergo surgery followed by 48 months of occupational therapy. The goal is to help them regain indep…

This study tests a single injection of VIA Disc NP, a processed human disc tissue, for people with long-term lower back pain from degenerated discs. About 121 participants will receive either the injection or a sham procedure. The goal is to see if the injection safely reduces pa…

This study tests whether a wearable suit that delivers small electrical pulses to leg muscles can improve walking speed in people with incomplete spinal cord injury. Participants first do standard treadmill training, then add the electrical stimulation suit for 20 sessions. The m…

This study tests whether a surgically implanted device that sends electrical pulses to the spinal cord can help people with spinal cord injury regain voluntary leg movement. Only 2 participants with specific injury levels and MRI evidence of spared nerve fibers will be enrolled. …

This study looks at a natural protein called Natural Matrix Protein (NMP) used as a bone graft substitute during lumbar spinal fusion surgery. Researchers will review the medical records of about 100 adults who had this surgery to see how well their bones fused and if there were …

This study tests whether stimulating the vagus nerve while doing rehabilitation exercises can help people with chronic spinal cord injury regain movement and sensation. Twenty participants who completed an earlier trial will receive active VNS paired with exercises targeting the …

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study looks at how well upadacitinib (RINVOQ) works for people with axial spondyloarthritis, a type of inflammatory arthritis that causes chronic back pain. About 338 adults in Germany will take the drug as prescribed by their doctor and be followed for 52 weeks. Researchers…

This study tests whether a special clot made from a patient's own bone marrow can help spine bones heal together faster and more reliably after spinal fusion surgery. The trial involves 96 adults with degenerative spine disease. Half will receive the standard bone graft, and the …

This program gives eligible people with acute spinal cord injury early access to the investigational drug elezanumab before it is officially approved. A doctor must decide if the potential benefit outweighs the risks for each patient. The program is only available in certain terr…

This study compares a new, less invasive surgery to the standard open surgery for children with paralytic scoliosis (a curved spine) after a spinal cord injury. The minimally invasive approach uses smaller cuts and aims to correct the spine while causing less blood loss, fewer co…

This early-stage trial tests whether injecting stem cells from donated umbilical cords into the spine can help repair degenerated discs in people with lower back and leg pain. Twenty patients who have not improved with other treatments will receive the injection right after a min…

This study is tracking 1,000 people who received a bone graft material called Natural Matrix Protein (NMP) during spine surgery for degenerative disc disease. Researchers will monitor bone fusion, pain, and disability over two years to see if NMP is safe and helps the spine heal.…

This study tests whether a two-step drug treatment can improve bone density in people with long-term spinal cord injury who have bone loss. Participants receive either romosozumab (a bone-building drug) or a placebo for 12 months, followed by denosumab (a bone-strengthening drug)…

This study tests a new titanium cage used in spinal fusion surgery for people with degenerative disc disease in the neck. Fifty participants will receive the device and be followed for up to 24 months to see if the bones fuse properly and if pain and function improve. It is a sma…

This study is observing about 881 people with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, or psoriasis who are taking Remsima (a biologic drug) either as a shot under the skin or through an IV. The goal is to track any serious side effects over time. Resear…

This study compares two types of implants used in back surgery for people with worn-out discs in the lower spine. About 60 adults will receive either a PEEK cage with bone-growing protein or a CONDUIT cage during a procedure called DLIF. Researchers will check which cage leads to…

This study follows 148 adults with cervical disc disease who received the Hexanium ACIF implant, a device placed between vertebrae to restore height and fuse the spine. Researchers will track pain, disability, and any serious side effects for up to 24 months after surgery. The go…

This early-phase study tests whether combining noninvasive spinal cord stimulation with the drug buspirone can help people with severe spinal cord injury take steps overground. Fifteen participants who have been paralyzed for at least a year will undergo various training and meas…

This study tests whether adding non-invasive ventilation (a breathing machine) or the drug Buspar to a special rowing exercise program can improve heart and lung fitness in people with high-level spinal cord injury. Seventy participants will exercise for 6 months while receiving …

This study compares two types of spinal fusion cages used in back surgery: a new titanium cage with a special rough surface and a standard plastic cage. About 100 adults with spine problems like narrowing of the spinal canal or slipped vertebrae will be randomly assigned to recei…

This small study tests a noninvasive method called transcutaneous spinal cord stimulation (scTS) to help children aged 7-12 with chronic cervical spinal cord injury regain hand function. Researchers will find the best placement and strength of stimulation on the neck and lower ba…

This study tests whether a special bone graft (Infuse) helps spine bones fuse together better after back surgery. About 600 adults with degenerative spine disease will be followed for two years. The goal is to see if the graft reduces pain, improves function, and safely helps bon…

This study looks back at the medical records of 200 people who received a Prodisc C Vivo device to replace two damaged discs in their neck. The goal is to see how often patients need additional surgery and how well the device performs compared to published data. Participants will…

This study looks at two treatments for chronic low back pain caused by worn-out spinal discs: a type of keyhole surgery and a therapy using the patient's own stem cells. Researchers will track 120 adults to see which approach better reduces pain and improves daily function. The g…

This study tests an oral drug called jaktinib in 265 adults with active ankylosing spondylitis, a type of arthritis that mainly affects the spine. Participants take either jaktinib or a placebo twice daily for 16 weeks. The main goal is to see if jaktinib can reduce pain and impr…

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This study tests a spine surgery for 20 teenagers (ages 12-21) with a specific type of scoliosis called Lenke 1. The goal is to correct the spine curve and improve quality of life. Researchers will measure how well the surgery works using X-rays and patient questionnaires.

This study compares a high-tech, computer-controlled knee-ankle-foot brace (C-Brace) to traditional braces in 30 people with spinal cord injury. Participants will train with the device for up to 20 sessions and then use it at home for 3 months. The main goal is to see if the smar…

This study follows 131 people who already received the Simplify Disc for cervical disc disease. Researchers will check the disc's safety and how well it works over 10 years. The goal is to see if patients have lasting pain relief and fewer complications.

This study is testing a metal plate (the NuVasive ACP system) used during neck spine surgery to treat conditions like disc disease, stenosis, or fractures. About 75 adults will receive the plate and be followed for up to 24 months to see how safe it is and how well it helps with …

This study follows 158 people who already received the Simplify artificial disc to treat cervical disc disease. Researchers will track how well the disc works over 10 years by measuring neck function, nerve health, and whether any additional surgeries or serious problems occur. T…

This study is tracking 1,050 adults who are getting NuVasive interbody implants during spine surgery for conditions like degenerative disc disease or spinal stenosis. Researchers are monitoring complications, bone fusion, and patient-reported pain relief over 24 months. The goal …

This study looks at how safe and effective special spinal implants are for people with worn-out discs or unstable neck bones. About 150 adults who need neck surgery will receive these implants and be followed for 24 months. The goal is to see if the bones fuse properly and if pat…

This study follows 300 adults aged 18-80 who need spinal fusion surgery for degenerative disc disease or spondylolisthesis. It compares three types of interbody implants (PEEK, 3D-printed titanium, and another) used with bone graft material. Researchers will track how well the bo…

This study is testing a special bone graft called Virtuos in people having spinal fusion surgery for degenerative disc disease. The goal is to see if it helps the bones heal together better and reduces pain and disability. About 150 adults will take part, and the study will compa…

This study compares a new artificial disc, the Synergy Disc, to standard spinal fusion surgery for people with one-level cervical degenerative disc disease that hasn't improved with other treatments. About 175 adults aged 18-70 with neck and arm pain or nerve symptoms are being f…

This study tests a new material called Natural Matrix Protein (NMP) fibers, made from human bone, for spine fusion surgery. It includes 200 adults with degenerative disc disease, spinal stenosis, or spondylolisthesis who need fusion of up to three vertebrae in the neck or lower b…

This study tests a new artificial disc (M6-C) for people with two damaged discs in their neck. It compares the disc to standard fusion surgery. The goal is to see if the artificial disc can safely improve neck function and reduce pain. About 156 adults with neck and arm pain from…

This study tests a device called PCSS used alongside standard neck fusion surgery to treat degenerative disc disease in the neck. About 236 adults aged 18-80 who need surgery on three neck levels will be enrolled. The goal is to see if the device helps bones fuse better and safel…

This study tests if stem cells taken from a patient's own belly fat and injected into the spine can safely help restore movement and feeling after a spinal cord injury. About 40 adults with paralysis will receive the treatment. The goal is to see if this approach can improve func…

This study tests a new bone graft material (P-15L) for spinal fusion surgery in people with degenerative disc disease. The goal is to see if it works as well as the standard bone graft in helping bones fuse together and reducing pain. About 290 adults aged 22-80 will take part, a…

This study tests an implanted stimulator and sensor that helps people with cervical spinal cord injury regain hand and arm function. Ten participants will use the device to perform everyday tasks like grasping objects. The goal is to improve independence and quality of life.

This clinical trial tests whether injecting stem cells into the spinal discs can reduce pain and improve function in people with chronic low back pain from degenerative disc disease. About 113 adults aged 18-60 who haven't gotten relief from standard treatments will receive eithe…

This expanded access program gives one patient with a spinal cord injury at the C5-C7 level a single infusion of their own stem cells (HB-adMSCs). The stem cells are taken from the patient's fat tissue and grown in a lab before being given back. The goal is to see if this approac…

This study tested a stem cell treatment for people with long-term spinal cord injuries. It involved three patients who received their own fat-derived stem cells through an IV. The goal was to see if the treatment could safely restore nerve signals and improve sensation or movemen…

This pilot study tests an 8-week program called REACH-SCI designed to help people with spinal cord injury (paraplegia) reduce the time they spend sitting. The program includes a wearable activity tracker, education, goal setting, one-on-one coaching, a peer support chat, and exer…

This phase 4 trial tests whether starting with romosozumab for 12 months and then switching to denosumab for another 12 months can better maintain bone density around the knee in people with recent spinal cord injury, compared to using denosumab alone. The study involves 40 adult…

This study planned to test whether donated umbilical cord blood could help adults with stroke or spinal cord injury. However, the trial was withdrawn before enrolling any participants, so no data or results are available.

This study tests a device called the RISES-T System, which uses mild electrical stimulation through the skin to help people with chronic spinal cord injury improve their mobility and reduce muscle stiffness. Ten participants will try different stimulation techniques while researc…

This study evaluates a portable, strap-fixed device for measuring ankle strength in people with weakness caused by lumbar disc herniation. It compares the device's readings to a standard laboratory machine in healthy volunteers, then tests it in patients to see if it reliably cap…

This study tests whether a radioactive tracer called 124I-evuzamitide can detect amyloid deposits in the heart and elsewhere in people aged 60 and older who have lumbar spinal stenosis or carpal tunnel syndrome. Participants will receive a single dose of the tracer and undergo a …

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

Researchers are testing whether injecting Botox into the bladder wall soon after a spinal cord injury can prevent lasting bladder damage. The study enrolls 10 adults with recent injuries at T6 or higher. Half receive Botox injections and half receive saline sham injections. The t…

This study tests the Shingrix vaccine in over 2,000 adults with autoimmune rheumatic diseases like rheumatoid arthritis and lupus, who are at higher risk for shingles. Researchers will compare vaccinated patients to unvaccinated ones to see if the vaccine is safe and triggers a s…

This study looks at whether showering once or twice with a special antiseptic soap before lumbar disc herniation surgery reduces the risk of surgical site infections. 86 participants will be randomly assigned to shower either the night before surgery or both the night before and …

Researchers at the University of Alberta are testing whether 5-HTP, a serotonin precursor, can change nerve excitability and motor function in people with spinal cord injuries. The trial enrolls six adults who sustained a spinal cord injury at least six months earlier. In a rando…

Researchers are testing whether a virtual walking program can reduce chronic pain and psychological distress in people with severe mobility impairment, mostly from spinal cord injuries or polio. Participants wear a head-mounted display and use a controller to guide an avatar thro…

Researchers are testing whether transcutaneous spinal stimulation, a non-invasive technique that sends mild electrical pulses through the skin, can help children with chronic spinal cord injury take steps. The study enrolls 8 children ages 4 to 12 who cannot stand or walk on thei…

Children who injure their spinal cord in the neck often lose hand and arm strength. This trial tests whether a device that sends mild electrical pulses through the skin to the spinal cord is safe and comfortable for children. Ten children with long-term spinal cord injuries will …

This study tests whether sildenafil (the drug in Revatio, similar to Viagra) can reduce urine leakage in people with spinal cord injuries. Twenty-four adults who have at least three leaks per week will take either sildenafil or a placebo for four weeks. Researchers will track how…

This study follows 166 people aged 45 and older who received the Superion IDS implant for lumbar spinal stenosis, a condition that narrows the spine and causes leg pain. The implant is designed to limit certain movements that worsen symptoms. Researchers are checking if patients …

This study looks at whether time-restricted eating (a form of intermittent fasting) is a practical way for veterans with spinal cord injury and obesity to lose weight. Fifteen veterans with paraplegia will try eating all their daily calories within a set window of time for 6 week…

This study tests whether combining motor skill training with a non-invasive spinal stimulation can improve walking, balance, and strength while reducing muscle spasticity in people with incomplete spinal cord injury. Twenty-eight participants will do a series of standing exercise…

This study tests a non-surgical method called transcutaneous spinal stimulation, which sends a mild electrical current through the skin on the lower back and abdomen to activate nerves in the spinal cord. Adults with a spinal cord injury who have leg stiffness or spasms will rece…

This early-stage trial is testing whether a new device called Regenn® Negative Pressure Therapy System is safe for people recovering from spinal fusion surgery. The device applies gentle suction to the surgical wound to help manage healing. About 30 adults will be randomly assign…

This study tests whether combining hand practice with a non-invasive spinal cord stimulation technique can reduce muscle tightness and improve hand function in people with chronic cervical spinal cord injury. Participants will perform hand tasks while receiving transcutaneous spi…

This study is testing an experimental injection called CELZ-201-DDT for people with long-term lower back pain caused by degenerative disc disease. The goal is to see if it is safe and can reduce pain and improve movement. About 45 adults aged 18 to 80 who have not gotten relief f…

This study tests whether taking essential amino acid supplements before and after spinal surgery helps adults with spinal deformity recover better. Twenty participants will take either the supplement or a placebo for two weeks before surgery and three months after. Researchers wi…

This study tests whether transcutaneous spinal cord stimulation (TSCS) — a gentle electrical current applied through the skin — can help veterans with chronic spinal cord injury (SCI) better regulate blood pressure during exercise and cold exposure. Participants will receive both…

This study tests whether a specific ultrasound-guided nerve block can reduce pain after elective lower back surgery better than the usual method of injecting pain medicine into the wound. Adults aged 18-65 undergoing surgery for conditions like a herniated disc or spinal stenosis…

This study tests a highly precise radiation system (CT-on-Rails or Trilogy) to treat spine tumors that have spread from other cancers. About 150 participants will receive three radiation sessions over two weeks. Researchers will track pain relief and side effects using patient qu…

This trial tests a minimally invasive surgery for cervical spinal stenosis, a condition where the spinal canal narrows and presses on the spinal cord. Instead of the standard approach that uses metal screws and rods, surgeons will only remove the tissue causing the compression th…

This study tests whether a non-invasive electrical stimulation applied to the back can boost the benefits of walking therapy for people with incomplete spinal cord injury. 18 adults with chronic spinal cord injury will receive either real or fake stimulation during their walking …

This pilot study tests a WeChat-based program that provides daily mental health check-ins and tailored coping strategies for people with ankylosing spondylitis who also have mild-to-moderate depression or anxiety. Thirty-six adults will be split into two groups: one receives the …

Many people with spinal cord injury struggle with slow bowel emptying and constipation. This study tests whether a small device that delivers gentle electrical pulses to the belly can speed up bowel movements and improve stool consistency. Twelve participants will use the stimula…

This study tests whether a single injection of rexlemestrocel-L (a type of stem cell) combined with hyaluronic acid can reduce chronic low back pain for at least 12 months. It involves 300 adults with moderate to severe pain from a worn spinal disc who haven't improved with stand…

This study compares two manual therapy techniques—Reciprocal Inhibition and Passive PNF Stretching—for people with chronic neck pain from cervical spondylitis. Sixty participants will receive 12 sessions over 4 weeks. Researchers will measure pain, disability, and neck movement t…

This study tests whether an implanted spinal cord stimulator can reduce chronic pain and improve rehabilitation outcomes in people with thoracic spinal cord injury. Twenty-five participants will either have the device turned on or off for three months, while both groups continue …

This study tests whether robotic-assisted walking training (using a device called Lokomat) can improve balance and walking smoothness in people with incomplete spinal cord injury. Thirty participants will be randomly assigned to either robotic training or standard physiotherapy. …

This study looks at two different ways to manage pain after lower back surgery without relying on drugs. About 267 adults will be randomly assigned to either standard care or an enriched pain management plan. The goal is to see which approach better reduces pain and helps people …

This study looks at whether a non-surgical treatment called spinal decompression can help people with chronic low back pain. About 42 adults with back pain from disc problems or sciatica will receive the treatment over 12 weeks. Researchers will use MRI scans and movement tests t…

This study aimed to see if a simple mindfulness breathing exercise could improve health and quality of life in people with spinal cord injury. Participants would have done a 10-15 minute guided breathing session three times a week for a month. However, the trial was withdrawn bef…

This study tests a treatment called Hypnosis Enhanced Cognitive Therapy (HYPCT) for people with new spinal cord injuries who are in rehab. It compares HYPCT to standard pain education to see if it can lower pain intensity and prevent chronic pain. Participants will attend four se…

This study tests an online program designed to help people with inflammatory arthritis remain employed. The program includes eLearning modules, group video sessions, and consultations with an occupational therapist and vocational counselor. About 528 participants from three Canad…

This study tests whether walking with a robotic exoskeleton three times a week for 12 weeks can reduce nerve pain in people with spinal cord injury. Forty adults with traumatic spinal injury and persistent nerve pain will be randomly assigned to either robotic walking or a relaxa…

This small pilot study is testing whether a daily low dose of naltrexone (4.5 mg) can reduce central neuropathic pain and improve quality of life in 10 adults with traumatic spinal cord injury. Participants take the drug for 12 weeks, and researchers measure pain scores and daily…

This study looks at two ways to numb people for lower back surgery: general anesthesia (being fully asleep) plus a nerve block, or spinal anesthesia (numbing only the lower body) plus a nerve block. The goal is to see which approach helps patients recover better and feel less pai…

This study compares two common procedures for chronic back pain caused by a slipped disc or narrowed spine: a steroid injection and a nerve-targeting radiofrequency treatment. Researchers will track pain levels in 200 adults right after the procedure and three weeks later. The go…

This trial tests whether a 10-week online health program called DRIV can help adults with long-term spinal cord injury adopt healthier habits and feel better. Participants attend weekly video group sessions covering exercise, nutrition, stress, and goal-setting. Researchers compa…

This study looks at whether using a powered exoskeleton to walk can improve quality of life for people with spinal cord injury. Eighteen participants will either use the device at home or in a clinic over 24 months. Researchers will measure changes in well-being and compare costs…

This study tests whether brief periods of breathing low oxygen can improve leg strength and walking in people with chronic spinal cord injury. Thirty adults with incomplete spinal cord injury will inhale low oxygen for short sessions over time. Researchers will measure walking en…

This study looks at whether nutrition education and one-on-one counseling can reduce chronic pain in people with spinal cord injury. Thirty adults will attend monthly sessions for four months, either in person or online. Researchers will measure changes in pain intensity and nerv…

This study tests whether repeated magnetic pulses (rTMS) aimed at the brain's motor area can safely reduce chronic nerve pain that hasn't responded to other treatments. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal cord injury will receive…

This study tests a device that stimulates the vagus nerve during arm rehabilitation exercises to see if it helps people with spinal cord injuries regain upper limb function. Twenty adults with chronic cervical spinal cord injury will receive either active or placebo stimulation d…

This early study tests whether combining a spinal cord stimulator with the drug buspirone can improve arm and hand movement in people with cervical spinal cord injury. Twelve participants will receive both the device and the drug, and their motor function will be formally assesse…

This study looks at whether a specific nerve block (called an erector spinae plane block) can improve pain control after surgery for a slipped disc in the lower back. Researchers will track pain scores, opioid use, how soon patients can walk, and how long they stay in the hospita…

This study tests whether 8 weeks of acceptance and commitment therapy (ACT) delivered via Zoom can help reduce depression in people with spinal cord injuries. 140 participants with mild or worse depressive symptoms will be randomly assigned to either ACT or a wait-list that conti…

This study tests whether adding mild electrical stimulation to the spinal cord (TSCS) to exoskeleton training helps people with incomplete spinal cord injury walk better. 30 participants within a year of injury will receive 24 training sessions. Researchers will measure walking s…

This study looks at whether a digital health program (Hinge Health) plus a wearable pain relief device (Enso) can help people with chronic low back pain feel better and move more easily. About 196 adults with back pain for at least 3 months will be randomly assigned to either the…

This study tests whether a short form of talk therapy, called brief prolonged exposure therapy, can help prevent post-traumatic stress disorder (PTSD) in people who have had a spinal cord injury. The therapy involves three one-hour sessions during inpatient rehabilitation. Resear…

This study tests whether a gentle electrical current (TENS) applied to the lower back can reduce muscle stiffness and improve movement in people with spinal cord injuries. Forty adults with injuries between the neck and mid-back will either receive TENS for two months or wait two…

This study compares a newer, less invasive spine surgery called unilateral biportal endoscopy (UBE) to traditional open surgery for people with a specific type of lower back and leg pain caused by a slipped vertebra and narrowed spinal canal. The goal is to see if the newer techn…

This study looks at whether a combination of herbal medicine and Chuna manual therapy (a Korean spinal manipulation technique) can safely reduce pain and improve walking ability in people with low back pain or sciatica caused by lumbar spinal stenosis or spondylolisthesis. Resear…

This study compares two procedures to relieve chronic tailbone pain (coccydynia) that is not related to cancer. About 74 adults aged 20-70 who have not responded to standard medical treatment will be split into two groups. One group will receive conventional radiofrequency ablati…

This study tests if a wrap made from donated birth tissue (amniotic membrane) can reduce swelling after a two-level neck fusion surgery. About 50 adults with neck spine problems will take part. The main goal is to see if the wrap lessens soft tissue swelling one month after surge…

This study tests a method called conditioning open-label placebo (COLP) to help patients with spinal cord injury, multiple injuries, or burns use fewer opioids while still getting the same pain relief. About 66 adults in intensive rehab will receive a placebo alongside their regu…

After lumbar spine surgery, many people stay inactive due to fear of pain or injury. This study tests a program that combines education, walking goals, and activity trackers to help 260 participants increase their daily walking. The goal is to see if this approach can reduce disa…

This study aimed to compare two treatments for chronic low back pain caused by worn-out discs: injections of a person's own stem cells (from bone marrow) versus steroid injections. It planned to enroll adults with pain lasting over 6 months who had not improved with other treatme…

This study looks at two treatments for long-term tailbone pain (coccydynia) that hasn't improved with basic care like cushions or physical therapy. Researchers will compare a nerve block alone versus the nerve block plus a steroid injection into the lower back. They will check if…

This study tests whether adding virtual reality (VR) to standard physical therapy helps people recover better after lumbar disc surgery. About 46 adults who had surgery on their lower back will either get standard therapy or standard therapy plus a 20-minute VR session. Researche…

This study tests a wearable robotic exoskeleton called EXPLORER in 15 children with movement problems from conditions like cerebral palsy. The goal is to see if it helps them walk better in their everyday environments, such as home and the community. The study focuses on safety, …

This study is developing and testing a mobile app that guides people with lumbar disc herniation through fascia exercises. Participants will be taught exercises by a physiotherapist and then use either the app, a home brochure, or standard lumbar stabilization exercises. The goal…

This study planned to test whether training on a rowing machine that uses electrical stimulation to move the legs could improve fitness in adults with traumatic paraplegia. Participants would have trained for 6 months, but the trial was withdrawn before anyone enrolled, so no res…

This study tests a training program that teaches children with physical disabilities how to use their manual wheelchairs better. The goal is to help them move around on their own instead of relying on others, which can improve their confidence and social life. Four children aged …

This study compares two types of nerve blocks—quadratus lumborum block and retrolaminar block—for pain after lumbar disc surgery. About 84 adults having elective back surgery will receive one of the two blocks before surgery. Researchers will measure pain scores, opioid use, and …

This study aimed to test a modified acupotomy technique for people with ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. The approach used ultrasound to guide the procedure, with the goal of reducing disease activity. However, the study was withdra…

This observational study follows adults with morbid obesity who undergo bariatric surgery to see how substantial weight loss affects the alignment of the spine and pelvis. Researchers measure spinal and pelvic positions on X-rays before surgery and again at 3, 6, and 12 months af…

Researchers are comparing four large language models, ChatGPT-4o, Claude, Grok 3, and Gemini 2.5 Pro, on how well they recommend electrode contact configurations for epidural electrical stimulation in spinal cord injury. The study uses five standardized synthetic scenarios and no…

Researchers are observing five people with spinal cord injury who have a personal robotic exoskeleton for walking. The study tracks how often and how long participants use the device at home and in the community over 12 months. It also measures changes in health, bladder and bowe…

This study uses interviews and focus groups to understand how transcutaneous tibial nerve stimulation (TTNS) impacts quality of life and daily activities in 75 people with neurogenic bladder from spinal cord injuries. Researchers aim to identify key themes about bladder function …

This study watches 24 adults who are getting standard neck fusion surgery with a special device called the BEE HA cage. The goal is to see how well the cage helps with pain and function over time. No new treatment is tested—just careful tracking of normal surgery results.

This study looks at records from over 500,000 Medicare beneficiaries with rheumatoid arthritis or ankylosing spondylitis who had major orthopedic procedures like joint replacements or spine surgery between 1999 and 2015. Researchers want to understand how often complications happ…

Researchers are reviewing past spinal fusion surgeries to see if patient-specific guides, called MySpine, place screws safely even in the most challenging bone. They will compare nerve irritation rates between standard screws and those in anatomically complex positions, known as …

This study will use a special blood test called mass spectrometry to look at immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors diagnose these conditions sooner. No treatments are being tested; …

This study collects spinal tissue from 300 children and adults during routine spine surgery. Researchers will analyze the tissue to understand the molecular causes of spine deformity and degeneration. The goal is to identify targets for future treatments.

This study tests whether everyday rehabilitation therapy sessions can be recorded and measured more objectively using wrist-worn sensors, a video camera, and an audio recorder. Adults with neurological conditions like stroke, Parkinson's disease, or spinal cord injury will wear t…

This study tests whether a virtual reality brain-machine interface can help people with spinal cord injury regain function. Participants imagine moving their legs while wearing an EEG cap and VR headset, receiving sensory feedback. The goal is to understand how the brain's commun…

This study investigates how people physically interact with each other during tasks like collaboration, competition, and cooperation. The goal is to design robot controllers that mimic these human behaviors, which could then be used in devices like exoskeletons to improve motor l…

This study looks at whether taking CT scans of the lower back while standing up gives doctors more useful information than the usual lying-down scans. About 20 adults who are already scheduled for a standard CT scan will also get a standing scan. The goal is to see if the standin…

This study investigates how people with axial spondyloarthritis (axSpA) experience sudden worsening of symptoms, known as flares. Over 12 months, 40 participants use a digital diary to track symptoms, diet, lifestyle, and self-management strategies, and provide blood samples duri…

This large observational study aims to collect medical data and biological samples from up to 5,000 people with chronic spinal cord injury or traumatic brain injury, as well as their family members and healthy volunteers. Researchers hope this information will help them better un…

This study looks at a protein called progranulin in the blood of people with ankylosing spondylitis (a type of arthritis that affects the spine) and compares it to healthy volunteers. Researchers want to see if progranulin levels are linked to disease activity and whether they ch…

This study investigates how common spinal nerve pain is in people with ankylosing spondylitis (AS) and whether it affects their sleep. Researchers will use questionnaires to assess pain, sleep quality, quality of life, and fatigue in 292 AS patients. The goal is to better underst…

This study looks at nerve-related pain in people with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Researchers will use a questionnaire to describe the pain and see how it relates to daily activities. About 130 adults with the condition will take par…

This study tests a new, low-cost device that creates controlled slips while people with incomplete spinal cord injuries walk on it. The goal is to measure how their balance changes, both standing still and moving. Ten participants who can walk without aids will be observed to bet…

This study aimed to collect real-world information on the safety and effectiveness of the Synergy Disc, a device used to treat degenerative disc disease in the neck. It planned to look at past and future patients who received the disc. However, the study was withdrawn before enro…

This study is a registry that collects medical records, quality-of-life questionnaires, and tissue samples from 900 people with spine tumors or other spine disorders. The goal is to learn more about these conditions to guide better treatment in the future. Participants must be be…

This study tests an 8-week online group program called Living Longer and Stronger with SCI, designed to help people with spinal cord injury improve their physical, mental, and social health as they age. Participants set health goals and make weekly action plans with support from …

This study compares robot-assisted spine surgery to the traditional method in 300 adults needing spinal fusion. The goal is to see if the robot helps place screws more accurately, reduces complications, and improves patient outcomes. Participants are randomly assigned to either r…

This study was designed to test a new tool that helps surgeons measure and adjust the spine during fusion surgery. The goal was to see if using the tool leads to better spinal alignment and improved patient outcomes, such as less disability. However, the study was withdrawn befor…

This study aims to develop a new way to measure how the spine moves during walking in children, both healthy and those with scoliosis. Researchers will use a special camera system and reflective markers placed on the skin to track movement. The goal is to create a reliable and ea…

This study compares immune responses to flu and COVID-19 vaccines between people with chronic spinal cord injuries and healthy individuals. Researchers will analyze blood samples to see if gene activity and antibody levels differ between the groups. The goal is to understand why …

This study compares three different therapy approaches to help people with cervical spinal cord injury improve arm, hand, and trunk control. Ninety-nine participants will complete 40 therapy sessions over 8 weeks, with follow-up at 12 weeks. The goal is to find which method works…

This study looks at three ways surgeons place screws in the spine during surgery: using a robot, using a navigation system, or doing it by hand. The goal is to see which method leads to fewer screws needing to be fixed in a second surgery within the first year. About 932 adults w…

This study looks back at 50 people who had surgery for rare spinal cord tumors between 2022 and 2024. Researchers want to see how the surgery changed their nerve function, movement, and daily life. They also track complications like infections or bleeding. The goal is to learn wh…

This early-phase study at the Cleveland Clinic is testing whether combining a type of brain stimulation (paired neurostimulation) with hand training on one side can improve hand movement and dexterity on both sides in people with cervical spinal cord injury. Seventeen participant…

This study reviews medical records of 40 adults with chronic leg pain from back problems who had a procedure called caudal epidural adhesiolysis. The procedure uses a thin tube to break up scar tissue around spinal nerves. Researchers want to find out which patient traits or proc…

This study looks at medical records of 3,500 adults who had a type of back surgery called ALIF between 2010 and 2020. The goal is to see if death rates from this surgery have gone down over the years and whether having a second surgery is riskier than the first. Researchers hope …

This study is observing 328 adults who receive a Neuro-Patch during brain or spine surgery to repair the protective lining around the brain or spinal cord. Researchers are tracking complications and how easy the patch is for surgeons to use. The goal is to gather real-world data …

This study aimed to create and test a new questionnaire to better measure how lumbar spinal stenosis limits daily activities. It planned to enroll adults aged 50 and older with the condition, who would fill out several online surveys. However, the study was withdrawn before any p…

This study looks at whether non-invasive spinal cord stimulation, combined with breathing, arm, or trunk training, can improve lung and breathing muscle function in people with spinal cord injuries. 36 adults with injuries at or above the T5 level are participating. The goal is t…

This study aimed to create a self-management program to help veterans with AIS D spinal cord injury improve their well-being. It was designed for veterans who have some movement and sensation but often struggle with emotional and social challenges. However, the study was withdraw…

This study aimed to understand how physical therapy affects spinal discs in people with low back pain. Researchers planned to use MRI scans to measure changes in the discs before and after 6 weeks of therapy. The goal was to see if these scans could predict which patients would f…

This study follows 50 adults with incomplete cervical spinal cord injuries to see how well certain tests capture their recovery over 6 months. Researchers will track things like movement, sensation, and balance to find the best ways to measure improvement. The goal is to make fut…

This study looks at whether common balance tests can tell doctors why a person is having trouble with balance. Researchers will test 330 people, including healthy volunteers and patients with stroke, vision problems, inner ear issues, spine problems, or spinal cord damage. The go…

This study is a large registry that will follow 5,000 people with psoriatic arthritis or spondyloarthritis across North America. Researchers will collect information on how different approved treatments work and their side effects over time. The goal is to better understand these…

This study looks at how well nerve monitoring works during spine surgery to prevent spinal cord damage. Researchers will track nerve signals in 500 adults having neck or upper back surgery. The goal is to make the alert system more accurate so surgeons can act faster to protect n…

This study looks at whether lying on your side or sitting upright gives a better view of the spine using ultrasound in people with a BMI over 30. Researchers will also compare two different ultrasound techniques and check how reliable the measurements are when done by doctors wit…

This study follows 150 adults undergoing back-of-the-neck and upper spine surgery with metal screws and rods (posterior fixation) for injuries, tumors, or worn-out discs. Researchers track complications, X-ray results, and patient-reported pain over time. The goal is to better un…

This study aimed to test whether high-frequency electrical stimulation could improve bladder control in people with spinal cord injury who already have a special device implanted. Researchers planned to compare high-frequency versus low-frequency stimulation in 5 to 10 participan…

This study was designed to see if a special saltwater solution (buffered 2% hypertonic saline) is better than standard fluids for children and teens having spine surgery for scoliosis. The goal was to compare how the body's acid-base balance and electrolyte levels changed during …

This study looks at whether helping people with inflammatory arthritis address social needs—like food, housing, or transportation—can reduce missed doctor visits. About 100 adults with conditions like rheumatoid arthritis or lupus who have missed appointments in the past year wil…

This study looks at early factors that might predict how well people recover after a traumatic spinal cord injury. Researchers will examine blood pressure management, pain medications, and biological markers from 800 patients. The goal is to find patterns that help doctors person…

This study looks at two common surgeries for a back condition called lumbar stenosis with a mild slip (spondylolisthesis). One surgery just removes bone to relieve pressure, the other also fuses bones together. The study also tests whether having a panel of spine experts review X…

This study planned to test a noninvasive device that stimulates the vagus nerve through the skin to see if it could help people recover consciousness more quickly after anesthesia. The researchers wanted to enroll adults undergoing lumbar spine surgery and measure how fast they w…

This study follows 22 adults undergoing spinal fusion surgery (LLIF or ALIF) to see how long hip and leg weakness lasts. Researchers measure muscle strength before surgery and again at 6 weeks, 12 weeks, and 6 months after. The goal is to give patients a clearer idea of when they…

This study follows 75 manual wheelchair users with spinal cord injuries over 3 to 5 years to see when and why shoulder problems start. Researchers use yearly MRIs and motion tracking to link daily activities to shoulder damage. The goal is to find ways to prevent shoulder pain an…

This study looks at whether a power wheelchair that can lift a child from sitting to standing is practical for kids with conditions like cerebral palsy, spinal cord injuries, or genetic diseases. Only 4 children aged 5-17 are taking part. The goal is to see if the chair helps the…

This study was designed to check how well the Arcadius XP L spine fusion device works and if it is safe for people with chronic low-back pain from conditions like degenerative disc disease or instability. The plan was to follow 60 patients for at least one year after surgery. How…