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Spinal stimulation plus drug may restore arm function in paralysis

NCT ID NCT02313194

Symptom relief Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early study tests whether combining a spinal cord stimulator with the drug buspirone can improve arm and hand movement in people with cervical spinal cord injury. Twelve participants will receive both the device and the drug, and their motor function will be formally assessed. The goal is to see if this combination can help restore some upper limb function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
buspirone
What this could lead to
If it works, this could point toward a way to improve arm and hand function in people with spinal cord injury, potentially increasing independence.
What could go wrong
This is a very small, early-phase trial with only 12 participants, so results may not apply widely. The combination approach is experimental and may not produce meaningful improvement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 12 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2013

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Stable medical condition without cardiopulmonary disease or dysautonomia that would contraindicate hand/arm movement 2. No severe cardiopulmonary diseases such as severe bradycardia, severe autonomic dysreflexia, and/or Chronic Obstructive Pulmonary Disease. 3. No painful musculoskeletal dysfunction, unhealed fracture, contracture, pressure sore, or infection that might interfere with upper extremity training 4. No clinically significant depression or ongoing drug abuse 5. No current anti-spasticity medication regimen 6. Non-progressive SCI above C5 7. Must not have received botox injections in the prior six months 8. Be unable to grip or move independently 9. Be at least one-year post injury 10. Must be at least 18 years of age 11. Segmental reflexes remain functional below the lesion 12. Female subjects of child-bearing potential must not be pregnant and must be using a medically acceptable method of contraception 13. No current implant(s) of neurostimulators, cardiac pacemakers, defibrillators, shunts, stents, or aneurysm clips, and must have no future exposure to diathermy following implantation 14. No coagulopathy, cardiac risk factors, or other significant medical risk factors for surgery 15. Must not be involved in another clinical trial 16. Must not have disorders or conditions that would require MRI monitoring Exclusion Criteria: None as long as inclusion criteria are met.

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Conditions

The condition(s) this trial relates to.

quadriplegia spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervical spinal cord injury Tetraparesis Tetraplegia

Contacts and locations

Locations

  • UCLA

    Los Angeles, California, 90095, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.