Spinal shock: new combo may get paralyzed patients stepping overground

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria by study group: 1. Participants with Motor Complete SCI: * 18-65 years old, * Stable medical condition, * At least 1-year post-injury, * Non-progressive SCI, * Motor complete paraplegia: Unable to voluntarily move any joint of the lower limbs, * Inability to walk independently due to SCI, * Presence of active spinally evoked responses over the lumbo-sacral spinal cord using spinal Cord Transcutaneous Stimulation (scTS). 2. Participants with Motor Incomplete SCI: * 18-65 years old, * Stable medical condition, * At least 1-year post-injury, * Non-progressive SCI, * Motor incomplete paraplegia: Able to voluntarily move at least 1 joint of the lower limbs bilaterally, * Inability to walk independently in the community due to SCI, * Presence of active spinally evoked responses over the lumbo-sacral spinal cord using scTS. Exclusion Criteria: * Untreated pressure sores, * Unhealed bone fractures, * Untreated active urinary tract infections, * Peripheral lower limb neuropathies unrelated to SCI, * Seizure disorders, * Cardiopulmonary disease unrelated to SCI, * Untreated anemia, * Ventilator dependency, * Female participants: Pregnant or planning to become pregnant during the time course of study, or nursing, * Healing wounds/surgical sites along the spine, levels T9-L5, * Anti-spasticity implantable pumps, * Untreated clinically significant depression, psychiatric disorders, or ongoing drug abuse, * Colostomy bag, urostomy, * Individuals with abnormal blood panel results related to hepatic function, Individuals with abnormal estimated glomerular filtration rate (eGFR) and increase Creatinine Clearance (CrCl) levels above the normal range, * Individuals unwilling or unable to wean from drug(s) that interact(s) with buspirone, such as: Monoamine oxidase inhibitors (MAOIs) - Selegiline (Emsam), Isocarboxazid (Marplan), Phenelzein (Nardil), and Tranylcypromine (Parnate).