University Of Louisville

This study tests a new treatment for people with advanced pancreatic cancer that has not spread to other organs. It combines a drug that helps the immune system fight cancer (Nivolumab) with a procedure that uses electrical pulses to destroy tumor cells (irreversible electroporat…

This study tests whether a non-invasive spinal cord stimulation device can improve blood pressure control in 40 adults with chronic spinal cord injury. Researchers will place electrodes on the skin over the spine and stimulate different areas to see if it stabilizes blood pressur…

This early-stage study tests whether adding a procedure called irreversible electroporation (IRE) — which uses electric pulses to destroy cancer cells — to standard chemotherapy can help control locally advanced pancreatic cancer. About 20 adults with stage III pancreatic cancer …

This study tests whether taking a probiotic called Lactobacillus rhamnosus GG (LGG) for 6 months can help people with alcohol use disorder drink less and reduce liver injury. About 60 heavy drinkers with alcohol-related liver disease will receive either LGG or a placebo. The goal…

This study aims to create a personalized treatment for eating disorders by using mobile technology to track individual symptoms and triggers. Researchers will test if matching treatment modules to a person's unique needs works better than standard therapy. The study involves 320 …

This study tests a non-invasive device that sends mild electrical pulses to the spinal cord to improve walking and balance in people with Parkinson's disease. The treatment targets movement problems that don't respond well to standard medications. Twenty adults with Parkinson's w…

This study tests a program called TIPPI-R that teaches children with cancer and their families ways to manage pain and distress during treatment. About 100 children aged 0-18 will either receive the program or standard care. Researchers will compare how well each group copes with…

This study looks at whether people with brain metastases can safely avoid the steroid dexamethasone before and after surgery. About 35 adults with new brain tumors and a suspicious or confirmed cancer elsewhere will be enrolled. The main goal is to see how many need to start dexa…

This study tests whether a gentle electrical stimulation of the spinal cord, combined with breathing exercises, can improve lung function in people with chronic spinal cord injury. About 36 adults will be split into three groups: breathing training alone, stimulation alone, or bo…

This study tests whether a combination of electrical spinal cord stimulation and breathing exercises can improve respiratory function in people with chronic spinal cord injury. Researchers will enroll 30 adults with a spinal injury at or above the chest level who have significant…

This study looks at how living in greener neighborhoods affects heart health and overall well-being. Researchers will measure changes in artery stiffness, blood pressure, and body composition in 835 adults aged 30-70 over two years. The goal is to understand if adding green space…

This study enrolls 40 healthy adults aged 18-85 to undergo two new, quick tests during an upper endoscopy: EndoFLIP (measures muscle function) and Mucosal Integrity (measures tissue health). The goal is to establish normal values so doctors can better diagnose acid reflux and swa…

This study looks at whether using sterile water instead of Betadine to clean the urethra before placing a temporary catheter changes the chance of getting a urinary tract infection or causes less pain. About 148 adults getting a catheter in a clinic will take part. The goal is to…

This study looks at a new way to treat severe brain bleeds caused by an aneurysm. Doctors will only coil the bulging part of the aneurysm, not the neck. The goal is to see if this method reduces the risk of another bleed and improves recovery. About 30 adults with severe bleeds w…

This study is a long-term database that follows 3000 people with gastroparesis, a condition where the stomach empties slowly. Researchers track symptoms, treatments, and quality of life over time to learn more about the disease. No new treatment is given; the goal is to gather in…

This study looks at how people judge distances and heights of objects around them while walking. Researchers want to understand how our vision works during everyday movements like walking or driving. Healthy adults with normal vision will be asked to estimate distances before and…