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New app aims to ease depression and pain in ankylosing spondylitis patients

NCT ID NCT07647965

Symptom relief Sponsor: The Hong Kong Polytechnic University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tests a WeChat-based program that provides daily mental health check-ins and tailored coping strategies for people with ankylosing spondylitis who also have mild-to-moderate depression or anxiety. Thirty-six adults will be split into two groups: one receives the program (including video CBT sessions and symptom-triggered exercises), while the other gets standard education. The main goal is to see if the program is feasible and acceptable, with early looks at its effects on mood, pain, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ecological momentary intervention (WeChat-based CBT sessions and symptom-triggered coping modules)
What this could lead to
If it works, this could provide a practical, on-demand mental health tool for people with ankylosing spondylitis, helping them manage pain, anxiety, and depression in real time.
What could go wrong
This is a very small pilot study (36 people) focused on feasibility, not proof of effectiveness. The results may not apply to broader populations, and the app-based approach may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical diagnosis of ankylosing spondylitis * Aged 18 years or above * Exhibiting mild to moderate levels of depression (scoring between 10 and 20 on the depression subscale of the Depression Anxiety Stress Scale-21 items) or anxiety (scoring between 8 and 14 on the anxiety subscale of the Depression Anxiety Stress Scale-21 items) * Maintained stable drug treatment in the 3 months before recruitment * Able to perform basic daily activities (such as walking, sitting, etc.) * Able to use a smartphone to engage in the ecological momentary intervention ● Proficient in Cantonese and/or Mandarin Chinese and have the necessary comprehension abilities to understand and be willing to give informed consent Exclusion Criteria: * Have a diagnosed mental illness or a history of mental illness * Have other severe chronic diseases (e.g., cardiovascular disease, cancer) that may affect study outcomes or intervention effects * Are currently participating in other psychosocial interventions

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Conditions

The condition(s) this trial relates to.

ankylosing spondylitis Psychological Well-Being

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ankylosing spondylitis (AS) Mental health

Contacts and locations

Locations

  • School of Nursing, The Hong Kong Polytechnic University

    Hong Kong, Hong Kong

  • The Rheumatology outpatient department at the First Affiliated Hospital of Guangzhou University of Chinese Medicine

    Guangzhou, China

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