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Breathing low oxygen may reboot walking after spinal injury

NCT ID NCT02632422

Disease control Sponsor: Spaulding Rehabilitation Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This study tests whether short, mild low-oxygen breathing sessions can improve walking and leg strength in people with a recent spinal cord injury. Over 10 sessions, participants breathe either low-oxygen air or normal air through a mask. The goal is to see if this simple approach can help retrain the nervous system and boost recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
mild low-oxygen air (intermittent hypoxia)
What this could lead to
If it works, this could point toward a simple, drug-free way to help people with spinal cord injury regain walking ability.
What could go wrong
This is an early-stage study with no phase designation, so results may not be conclusive. The effect may be small or not last long, and not everyone may benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 125 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2015

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 to 70 years old * medically stable with medical clearance from physician to participate * spinal cord injury (SCI) at or below C3 (phrenic sparing) and above L5 with at least motor function preserved below the neurologic level * non-progressive etiology of spinal injury * American Spinal Injury Association Impairment Scale (AIS) grade A-D * 2-12 months post-injury (subacute) Exclusion Criteria: * severe concurrent illness or pain, including unhealed decubiti, severe neuropathic or chronic pain syndrome, infection (e.g. bladder), hypertension, cardiovascular disease, pulmonary disease, severe osteoporosis (history of fractures), active heterotopic ossification in the lower extremities, or history of peripheral nerve injury in the legs * score less than 24 on Mini-Mental Exam * severe autonomic dysreflexia * history of cardiovascular/pulmonary complications * pregnancy * severe obstructive sleep apnea (OSA), characterized by uncontrolled hypoxia and sleep fractionation Specific inclusion/exclusion criteria for recruiting non-ambulatory subjects: Participation in this group requires all of the above inclusion/exclusion criteria, as well as being unable to complete any of the below measures: * timed up-and-go (TUG) test * 10-meter walk test (10MWT) * 6-minute walk test (6MWT) Specific inclusion/exclusion criteria for recruiting ambulatory subjects: Participation in this group requires all of the above criteria, as well as successful completion of at least one below measure: * timed up-and-go (TUG) test * 10-meter walk test (10MWT) * 6-minute walk test (6MWT)

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Conditions

The condition(s) this trial relates to.

spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spinal cord injury

Contacts and locations

Locations

  • Shepherd Center

    Atlanta, Georgia, 30309, United States

  • Spaulding Rehabilitation Hospital

    Cambridge, Massachusetts, 02138, United States

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