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New hope for kids with arthritis: drug trial shows promise

NCT ID NCT04527380

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This study tests whether the drug ixekizumab is safe and effective for children with certain types of juvenile arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). About 101 children aged 2 to 17 years will receive either ixekizumab or the standard drug adalimumab. The goal is to control disease activity and improve symptoms, but children will need to continue medication long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

101 people

The number who actually took part.

Started

Apr 2021

Expected to finish

Jan 2029

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants must have active juvenile idiopathic arthritis (categories of enthesitis related arthritis or juvenile psoriatic arthritis) * Participants must have weight of at least 10 kilograms (Kg), age starting at 2 years for participants with juvenile psoriatic arthritis and starting at 6 years for participants with enthesitis related arthritis * Participants must have all immunizations up-to-date in agreement with current immunization guidelines, in the opinion of the investigator Exclusion Criteria: * Participants must not have active or history of inflammatory bowel disease * Participants must not have active uveitis * Participants must not have active or latent tuberculosis * Participants must not have an active infection * Participants must not have concurrent use of biologic agents for the treatment of the juvenile idiopathic arthritis

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Conditions

The condition(s) this trial relates to.

enthesitis-related juvenile idiopathic arthritis juvenile ankylosing spondylitis juvenile idiopathic arthritis psoriasis-related juvenile idiopathic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Enthesitis related arthritis Juvenile psoriatic arthritis

Contacts and locations

Locations

  • A.O.Universitaria Meyer

    Florence, Tuscany, 50139, Italy

  • Aarhus Universitetshospital, Skejby

    Aarhus, Central Jutland, 8200, Denmark

  • Alder Hey Children's Hospital

    Liverpool, England, L14 5AB, United Kingdom

  • Asklepios Klinik Sankt Augustin

    Sankt Augustin, North Rhine-Westphalia, 53757, Germany

  • Azienda Ospedaliera Spedali Civili di Brescia

    Brescia, 25123, Italy

  • Bristol Royal Hospital for Children

    Bristol, Bristol, City of, BS2 8BJ, United Kingdom

  • CITER Centro de Investigación y Tratamiento de las Enfermedades Reumáticas

    Mexico City, Mexico City, 06700, Mexico

  • Centre d'Investigation Clinique Loc. 1

    Paris, 75015, France

  • Centro Medico Privado de Reumatologia Loc. 20

    San Miguel de Tucumán, Tucumán Province, T4000AXL, Argentina

  • Centro Specialistico Ortopedico Traumatologico Gaetano Pini - CTO

    Milan, Lombardy, 20122, Italy

  • Charité Campus Virchow-Klinikum

    Berlin, 13353, Germany

  • Cliniques universitaires Saint-Luc

    Brussels, Bruxelles-Capitale, Région de, 1200, Belgium

  • Dětská klinika Loc. 11

    Olomouc, 779 00, Czechia

  • Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

    Milan, Lombardy, 20122, Italy

  • H.R.U Málaga - Hospital Materno-infantil

    Málaga, 29011, Spain

  • Haywood Community Hospital

    Stoke-on-Trent, Staffordshire, ST6 7AG, United Kingdom

  • Helios Klinikum Berlin-Buch

    Berlin, 13125, Germany

  • Hospital Infantil Universitario Niño Jesús

    Madrid, Madrid, Comunidad de, 28009, Spain

  • Hospital Sant Joan de Déu

    Esplugues de Llobregat, Barcelona [Barcelona], 08950, Spain

  • Hospital Universitari i Politecnic La Fe

    Valencia, 46026, Spain

  • Hospital Universitario Virgen Del Rocio

    Seville, 41013, Spain

  • IRCCS Istituto Giannina Gaslini

    Genoa, Liguria, 16147, Italy

  • Instituto CAICI SRL Loc. 15

    Rosario, Santa Fe Province, S2000, Argentina

  • Klinika detskeho a dorostoveho lekarstvi Loc. 1

    Prague, 12808, Czechia

  • Klinikum Bremen-Mitte

    Bremen, 28177, Germany

  • Oddeleni revmatologie deti a dospelych Loc. 1

    Prague, Praha 5, 150 06, Czechia

  • Ostschweizer Kinderspital

    Sankt Gallen, 9006, Switzerland

  • Oxford University Hospitals - Nuffield Orthopaedic Centre

    Oxford, Oxfordshire, OX3 7HE, United Kingdom

  • Praxis Kinder- und Jugendrheumatologie Dr. Ivan Foeldvari

    Hamburg, 22081, Germany

  • Queen's Medical Centre, Nottingham University Hospitals

    Nottingham, Nottinghamshire, NG7 2UH, United Kingdom

  • RHUMATOLOGIE Loc. 1

    Poitiers, Vienne, 86021, France

  • Rhumatologie pediatrique et CEREMAIA Loc. 1

    Le Kremlin-Bicêtre, Paris, 94270, France

  • Royal Stoke University Hospital

    Stoke-on-Trent, Staffordshire, ST4 6QG, United Kingdom

  • Service de consultation pédiatrique Loc. 1

    Montpellier, Hérault, 34090, France

  • Service rhumatologie Loc.

    Bron, Auvergne-Rhône-Alpes, 69500, France

  • Sheffield Children's Hospital

    Sheffield, S10 2TH, United Kingdom

  • St. Josef-Stift Sendenhorst

    Sendenhorst, North Rhine-Westphalia, 48324, Germany

  • UMC Utrecht - Wilhelmina Kinderziekenhuis

    Utrecht, 3584 EA, Netherlands

  • UZ Gent

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • UZ Leuven

    Leuven, Vlaams-Brabant, 3000, Belgium

  • Universitaetsklinikum Freiburg

    Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany

  • University of Naples Federico II

    Naples, Campania, 80131, Italy

  • Universitäts-Kinderspital beider Basel

    Basel, Canton of Basel-City, 4031, Switzerland

More trials for these conditions

Other studies related to the condition(s) this trial covers.