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Spinal zaps may steady blood pressure in spinal cord injury

NCT ID NCT05960448

Symptom relief Sponsor: James J. Peters Veterans Affairs Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This study tests whether transcutaneous spinal cord stimulation (TSCS) — a gentle electrical current applied through the skin — can help veterans with chronic spinal cord injury (SCI) better regulate blood pressure during exercise and cold exposure. Participants will receive both active and sham stimulation while using an arm bike or sitting in a cool room, and researchers will measure exercise endurance, heart rate recovery, core temperature, and thermal comfort. The goal is to see if TSCS can improve autonomic function, which often becomes impaired after SCI, leading to issues like orthostatic hypotension.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcutaneous spinal cord stimulation (TSCS) — electrical stimulation delivered through the skin to the spinal cord, compared to a sham (placebo) version.
What this could lead to
If effective, TSCS could offer a non-invasive way to help people with spinal cord injuries maintain blood pressure and tolerate exercise and temperature changes better.
What could go wrong
This is a small early-stage crossover study with no expected long-term benefit. Results may not apply broadly, and the stimulation may not improve outcomes beyond placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2023

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * You are above the age of 18 years old * You have an SCI between C3-T6 * You have been injured longer than 1 year * You participated in a prior experiment "Targeted Transcutaneous Spinal Cord Stimulation to Restore Autonomic Cardiovascular Health in Individuals with Spinal Cord Injury" * You have an American Spinal Injury Association injury classification scale (AIS) A, B, C * Your prescription medications have not changed for at least 30 days Exclusion Criteria: * You have a history of seizures * You have an acute illness or infection * You have diabetes * You have untreated thyroid disease * You have a neurological condition other than SCI (Alzheimer's disease, dementia, stroke, multiple sclerosis, Parkinson's disease, etc.) * You have a history of heart or vascular disease (coronary artery disease, congestive heart failure, peripheral artery disease,) * You have a history of moderate or severe head trauma (TBI) or diagnosed with cognitive impairment * You have a present or history of a psychological disorder * You have contraindications to electricity over your spine * You are dependent on a ventilator to breathe or have an open tracheostomy site * You have a recent history of substance abuse (within the past 3 months) * You have open wounds over the spine at the level targeted for stimulation * You are pregnant

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Conditions

The condition(s) this trial relates to.

Hypotension, Orthostatic Motor Activity orthostatic hypotension spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Orthostatic hypotension

Contacts and locations

Locations

  • James J Peters VAMC

    The Bronx, New York, 10468, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.