Vertebral column disorder

This phase 3 trial tests whether an experimental drug called KP-100IT, injected into the spinal fluid, can help people with severe acute spinal cord injuries regain function. Participants, aged 18 to 89 with a complete loss of motor and sensory function (AIS grade A), receive fiv…

This trial tests whether adding a procedure called expansile duraplasty — opening and expanding the tough membrane around the spinal cord — to standard spinal surgery can improve neurological recovery in adults with acute severe spinal cord injury. Participants are randomly assig…

This trial tests whether an 8-week upper-limb resistance training program can improve cardiovascular autonomic function in adults with chronic spinal cord injury. Participants are randomly assigned to either supervised arm exercises three times per week or a control group. Resear…

This trial tests whether NVG-291, an investigational peptide, can improve hand function and daily activities in adults with chronic cervical spinal cord injury. Participants receive either NVG-291 or a placebo by daily injection under the skin for 12 weeks. Researchers measure ch…

This trial tests whether daily seated cycling, started within two days of spinal surgery, can improve recovery in people with a mild spinal cord injury. Researchers will compare 107 participants who cycle for 30 minutes each day during their hospital stay with a similar group who…

This early study tests whether washing the bladder with an antibiotic (gentamicin) followed by a probiotic (Lactobacillus) can help restore healthy bacteria and prevent urinary tract infections in people with neurogenic bladder due to spinal cord injury, multiple sclerosis, or sp…

This trial compares two FDA-approved cages used in lower back fusion surgery to see if one helps the bones fuse together better than the other. Adults undergoing a 1- or 2-level lumbar fusion for degenerative disc disease will be randomly assigned to receive either a cage with a …

This early-stage trial tests a new cell-based injection called TG-C for people with long-term lower back pain due to degenerative disc disease. 24 adults aged 22 to 70 will receive either a high, mid, or low dose of TG-C injected into the spinal disc, or a sham (fake) injection. …

This trial is testing whether ProteiOS®, a growth factor derived from donor bone, can help bones in the lower spine fuse together as effectively as the standard approach using a patient's own bone. Adults with degenerative spine conditions needing lumbar fusion surgery will be ra…

This trial tests whether testosterone therapy can help men with spinal cord injury who have low testosterone and difficulty walking. The goal is to see if it increases muscle and bone in the legs, reduces body fat, and improves strength. Some participants also receive finasteride…

This early-stage trial is testing whether combining a robotic exoskeleton with spinal cord stimulation can help people with chronic spinal cord injury walk more easily. The study will include a small group of adults who already have a spinal stimulator implanted and have complete…

This study tests whether adding a mild electrical stimulation to the spinal cord (tSCS) during walking therapy can improve leg movement in people with recent spinal cord injury (within 6 months). Forty participants will receive either real or sham stimulation during 20 training s…

This trial is testing whether a single injection of stem cells from umbilical cord tissue, given into the spinal fluid, is safe and tolerable for people who have had a traumatic spinal cord injury within the past ten years. The study will monitor participants for side effects and…

This study tracks the safety of secukinumab, a biologic injection, in Indian adults with axial spondyloarthritis — a group of inflammatory conditions that cause back pain and stiffness. Over 16 weeks, researchers will monitor side effects and disease activity in about 60 particip…

This study tests whether combining spinal cord stimulation with physical therapy can improve arm and hand movement in people with cervical spinal cord injury. Forty participants will receive either real stimulation or a sham version during 20 therapy sessions over 6-8 weeks. Rese…

This study will test a mobile brain-computer interface (iBCI) that lets people with severe paralysis control computers and mobile devices using only their thoughts. Two veterans with conditions like spinal cord injury or ALS will use the device at home. The goal is to see if the …

This study tests a device called the ReWire system, which is implanted to stimulate the vagus nerve during leg rehabilitation. The goal is to see if this paired stimulation can safely improve walking in people with chronic, incomplete spinal cord injury. The trial involves 20 par…

This trial tests whether adding a posterior cervical fusion (using the CORUS PCSS 3D device) to the standard anterior cervical discectomy and fusion (ACDF) improves bone fusion success for people with two-level degenerative disc disease in the neck. About 225 adults with neck or …

This study will test whether combining exoskeleton-assisted walking with a mild electrical stimulation to the spinal cord can improve muscle size and bone strength in people with chronic spinal cord injury. Twenty-four participants who have been injured for more than three years …

This trial investigates whether combining high-frequency magnetic stimulation of the sacral nerve roots with ultrasound therapy to the bladder can reduce involuntary bladder contractions in people with spinal cord injury. Participants receive daily treatments for three weeks, and…

This study tracks the safety and effectiveness of a stent graft device used to treat aneurysms, dissections, or trauma in the aortic arch (the curved part of the main artery from the heart). Researchers will follow 75 patients in Japan who receive the device, monitoring for compl…

This study tests whether a special arm-crank exercise (eccentric training) can improve upper body strength and daily function better than standard strength training for people recovering from a spinal cord injury. Twenty participants will do 20 sessions of one type of training ov…

This study explores whether applying mild electrical stimulation to the spinal cord through the skin can improve blood pressure control in people with spinal cord injury. Participants will undergo tilt-table tests to measure immediate effects, plus 20 stimulation sessions to see …

This study tests a new medicine called CBT005, a healing protein injected directly into damaged spinal discs. The goal is to see if it is safe and can reduce long-term back pain in 60 adults with disc degeneration. Participants get one injection and are followed for up to 3 years…

This trial compares two surgical approaches for people who develop spinal stenosis near a previous lumbar fusion. One group receives a smaller surgery (microdecompression alone), while the other gets the standard larger surgery (decompression plus extending the fusion). The study…

This early-phase trial is testing whether stem cells from donated bone marrow (CG-BM1) are safe for people with ankylosing spondylitis, a chronic inflammatory arthritis. Forty adults aged 18 to 40 will receive either the stem cells or a placebo by IV once a week for four weeks. T…

This study tests whether a device that electrically stimulates the abdominal muscles can improve cough strength in 150 adults with a recent spinal cord injury. Participants will use the device during breathing exercises for up to 6 weeks. The goal is to see if it helps clear mucu…

This early-stage trial tests whether transplanting a patient's own nose cells into the spinal cord, combined with intensive exercise, is safe and possible for people with chronic spinal cord injury. About 30 participants will receive the cell transplant and a 32-week rehab progra…

This study tests a surgery called selective dorsal rhizotomy to reduce severe muscle stiffness (spasticity) caused by traumatic brain or spinal cord injury. The surgery involves cutting specific nerve rootlets in the spine to relax overactive muscles. Researchers will enroll 32 p…

This study follows 150 people who received a BDyn spine implant for degenerative disc disease to see how many need additional surgery at the level above the implant over at least 4 years. Participants will complete surveys, undergo imaging, and report any side effects. The goal i…

This study tests a brain-computer interface (BCI) implant in 10 people with tetraplegia (paralysis of all four limbs) from brainstem or spinal cord injury. The implant reads brain signals to control a pneumatic hand glove, helping patients grasp objects like cups or phones. The t…

This early-phase trial tests a new stem cell treatment (HS_SW01) for people with ankylosing spondylitis, a type of arthritis that causes spine pain and stiffness. The study will include 18 adults aged 18 to 65. Researchers aim to check if the treatment is safe and if it helps red…

This study tests whether a drug called istradefylline can boost the walking improvements seen with low-oxygen therapy in people with chronic, incomplete spinal cord injury. About 40 adults aged 18-75 with injuries at least one year old will receive the drug or a placebo before wa…

This study compares two surgical devices used in neck fusion surgery for cervical degenerative disc disease. One device is a cage with built-in screws, the other is a traditional cage without screws. The goal is to see which leads to better bone fusion and fewer complications. Fo…

This study tests whether combining spinal cord stimulation with physical therapy can help people with non-traumatic spinal cord injury regain leg movement and the ability to stand or step. Ten adults who have had a spinal cord injury for at least one year and cannot walk independ…

This study tests a new device called SSMD, which uses non-invasive stimulation to help people with movement problems after stroke, traumatic brain injury, spinal cord injury, or peripheral nerve damage. 120 adults aged 18-80 with moderate to severe arm impairment will receive eit…

This study tests whether the drug upadacitinib can reduce how often people with axial spondyloarthritis (a type of arthritis affecting the spine) get sudden eye inflammation (acute anterior uveitis). About 200 adults who have had at least one eye flare in the past year will take …

This early-stage trial tests whether a single dose of CRIS100 is safe for people with a recent spinal cord injury in the upper back. Only 5 adults with severe injuries will receive the drug directly at the injury site within 72 hours. The study focuses on side effects and lab cha…

This study tests whether walking in a robotic exoskeleton combined with mild electrical stimulation of the spinal cord can improve muscle and bone health in people with chronic spinal cord injury. About 24 participants will be assigned to either active or sham stimulation during …

This study looks at whether it is safe to avoid antibiotics before bladder Botox injections in people with multiple sclerosis or spinal cord injury who have bacteria in their urine but no symptoms. About 526 participants will be randomly assigned to receive either antibiotics or …

This study tests a new artificial disc called Triadyme-C for people with painful neck and arm problems from a single damaged disc. About 164 adults who haven't gotten better with other treatments will get the new disc. The goal is to see if it safely improves pain, movement, and …

This study tests whether metformin, a common diabetes medicine, can help people recover after a spinal cord injury. The drug may reduce scar tissue that blocks nerve healing. Researchers will give metformin or a placebo to 34 adults with recent thoraco-lumbar spinal cord injury a…

This early-phase study tests whether a concentrated form of the patient's own growth factors can improve motor function after a spinal cord injury. Ten adults with moderate to severe traumatic spinal cord injury will receive the treatment. The goal is to see if this approach can …

This study tests a new stem cell therapy called XS228 for people with recent spinal cord injuries. The treatment uses lab-made nerve cells injected into the spinal fluid to help repair damage. About 60 adults with incomplete paralysis will receive either XS228 or a placebo and be…

This study looks back at medical records of 300 people who had neck spine fusion surgery using a special graft material called NMP®. The goal is to see how safe it is by checking for complications and whether patients needed another surgery within 90 days to 2 years. The research…

This study follows 16 people who already received EG110A, a gene therapy that uses a modified herpes virus to deliver a botulinum toxin-like protein to relax bladder muscles. Researchers will track side effects and how well the treatment works over five years. The goal is to see …

This study looks at a special putty called Fibergraft used in spine surgery to help bones grow together. About 80 adults with back pain or nerve problems from spine issues will get this putty during surgery. Doctors will check how well the bones heal using CT scans and ask patien…

This study compares two types of back surgery for people with narrowing of the spine in the neck (cervical stenosis). The goal is to see which surgery better improves nerve function and quality of life. Only 2 adults aged 40 and older who need surgery will take part, and they wil…

This study tests whether a Mediterranean diet can lower disease activity and improve quality of life in 110 people with axial spondyloarthritis (a type of arthritis affecting the spine) who are already on biologic therapy. Participants will either follow a structured Mediterranea…

This study tests a wearable microwave sensor that monitors bladder fullness without needles or catheters. About 40 adults with spinal cord injury who use self-catheterization will wear the sensor while their bladder fills and empties. The goal is to see if the device can accurate…

This study looks at whether CT scans taken during lumbar spine surgery can detect spinal instability more reliably than standard X-rays taken before surgery. Researchers will review imaging and medical records from 100 adults undergoing surgery for degenerative spine conditions. …

This study tests a new way to inject numbing medicine directly into a specific nerve root to find out which nerve is causing back and leg pain. The goal is to see if this method is safer and more accurate than current techniques. About 80 adults with sciatica who are scheduled fo…

This study compares two ways to diagnose bleeding problems during surgery: a quick bedside test (viscoelastic test) and standard lab tests. The goal is to see which method gives faster results, helping doctors treat bleeding sooner. About 210 adults having high-risk surgeries (li…

This phase 2 trial tests whether a nitric oxide spray (glyceryl trinitrate) can prevent dangerous blood pressure spikes during bowel care in people with spinal cord injury. 26 participants will receive either the active spray or a placebo during two at-home bowel care sessions. T…

Researchers compare how people with paraplegia perform and feel about four daily tasks when using a self-balancing exoskeleton versus a manual wheelchair. Five participants attend daily sessions where they do tasks like making coffee or brushing teeth with each device. The study …

Many people with lumbar spinal stenosis get pain relief from decompression surgery but still do not walk more afterward. This pilot trial tests whether a behavioral program can change that. Researchers randomly assign 75 patients aged 40 to 85 to either the program, which pairs m…

This study tests whether a self-balancing exoskeleton called XoMotion-R can help people with spinal cord injury (SCI) walk hands-free during rehab. Researchers will recruit 16 participants (8 inpatients and 8 outpatients) with specific levels of SCI to try the device. The goal is…

People with spinal cord injuries often rely on a bowel program to manage neurogenic bowel, a condition that makes it hard to control bowel movements. This trial compares three tools used during those programs: a bisacodyl suppository, a mini enema called Enemeez, and a transanal …

Researchers compare three fluoroscopy-guided epidural steroid injection techniques for adults with leg pain from a herniated disc. Ninety-nine participants receive either a high-volume interlaminar injection, a low-volume interlaminar injection, or a transforaminal injection. The…

Anterior cervical discectomy and fusion is a common neck surgery that can leave people with swallowing trouble, weaker breathing muscles, neck pain, and reduced quality of life. This trial tests whether a structured rehabilitation program improves those problems. Sixty adults who…

This pilot trial tests whether a non-invasive nerve stimulation technique, called transcutaneous tibial nerve stimulation (TTNS), can help people with spinal cord injuries who have overactive bladder muscles. Participants will use a small device to deliver mild electrical pulses …

This trial tests whether an 8-week virtual reality-based cognitive behavioral therapy (VR-CBT) program, done at home before elective spine surgery, can improve recovery and quality of life. Adults scheduled for spinal fusion will be randomly assigned to receive VR-CBT plus usual …

This trial tests whether adding a wearable postural biofeedback device to a standard exercise program can improve disease activity, pain, and function in people with axial spondyloarthritis, a type of inflammatory arthritis affecting the spine. Participants will do supervised exe…

This study tests whether a 6-week mindfulness meditation app can reduce pain intensity and improve mood in people with spinal cord injury who have chronic pain. Participants are randomly assigned to either use the mindfulness app or a health education app. The goal is to see if t…

This study tests whether injecting platelet-rich plasma (PRP) into the epidural space during endoscopic disc herniation surgery can reduce nerve pain in the leg. PRP is made from the patient's own blood and may help healing and reduce inflammation. The trial will enroll 50 adults…

This study tests a patient empowerment program for veterans with spinal cord injury and neurogenic bladder who have had at least one urinary tract infection in the past year. The program provides training and tools to help them recognize when antibiotics are not needed and advoca…

This study tests whether a 16-week home-based program combining functional electrical stimulation (FES) with high-intensity interval training (HIIT) is safe, practical, and acceptable for adults with spinal cord injury. Participants will use a portable FES device to activate para…

This study looks at two ultrasound-guided nerve blocks used to manage pain after lumbar spine surgery: the classic TLIP block and the QIP block. Adults aged 18-65 having elective lumbar discectomy will receive one of these blocks as part of their routine care. Researchers will tr…

This study tests a small ear device that gently stimulates a nerve (taVNS) in people who recently had a spinal cord injury. The goal is to see if it is safe and comfortable, and whether adding it to walking therapy might help improve mobility. About 50 adults will take part in tw…

This trial tests whether a hands-on spinal manipulation technique, called lever positioning manipulation, can ease the leg and back pain caused by a herniated disc. About 84 adults with a herniated disc will receive either the real manipulation or a sham version three times a wee…

This trial compares two adaptive indoor rowing seats designed for Veterans who have limited trunk stability due to spinal cord injury, stroke, or neurodegenerative conditions. Participants will try both seats during short rowing sessions, and researchers will measure trunk moveme…

This study tests whether applying myofascial release—a manual therapy that relaxes tight muscles—to the arms can improve sprint speed in wheelchair rugby players with spinal cord injury. Twelve athletes will complete a 20-meter sprint test with and without the therapy on separate…

This study tests whether adding Kinesio Taping to a standard bowel program can improve bowel function in adults with spinal cord injury. Thirty participants will be randomly assigned to receive either the bowel program alone or the bowel program plus Kinesio Taping applied to the…

This study compares two surgical options for people who develop spinal stenosis (narrowing of the spine) above a previous fusion site. One group gets decompression alone (removing tissue pressing on nerves), while the other gets decompression plus extended fusion (adding screws a…

This study tests whether pelvic floor down training—gentle breathing and relaxation exercises—can reduce tailbone pain in new mothers. Fifty-two women, 6 months to 1 year after childbirth, will practice these exercises daily. Researchers will measure pain and daily function befor…

This early-phase trial tests a wearable device that delivers mild electrical stimulation to a nerve near the genitals, aiming to improve bladder control in men with spinal cord injury. The study will enroll 12 participants and measure changes in bladder capacity and device usabil…

This study tests whether giving magnesium during back surgery can reduce the confusion and agitation some patients feel when waking up. 70 adults having a single-level lumbar microdiscectomy will receive either magnesium or a placebo. Researchers will monitor agitation, pain, and…

This study will test whether walking on an antigravity treadmill can boost heart and lung fitness and improve leg function in 60 people with incomplete spinal cord injury. Participants will do gait training on the treadmill or between parallel bars. The goal is to see if this spe…

This study looks at two ways to help people recover after surgery for a slipped disc in the lower back. One group will start moving early, and the other will do the same plus get mild electrical stimulation on their muscles. The goal is to see which approach reduces pain and impr…

This study tests whether eating at least 6 servings of fermented foods daily for 10 weeks can improve bowel function and gut health in adults with chronic spinal cord injury. Participants will be randomly assigned to either a high-fermented-food diet or a control diet. The resear…

This study will develop and test a new digital pain rehabilitation program for people with spinal cord injury (SCI) who have chronic pain. The program is based on a biopsychosocial model, which looks at physical, emotional, and social factors. The study will enroll 32 adults who …

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This study tests two ways to guide a steroid injection for people with lumbar spinal stenosis, a condition that causes back and leg pain when walking or standing. One method uses X-ray (fluoroscopy) alone, the other adds ultrasound before the X-ray (hybrid). The goal is to see wh…

This study will compare two types of nerve blocks—lumbar paravertebral block and lumbar erector spinae plane block—for pain control after lumbar spine surgery in people aged 65 and older. The goal is to see which block reduces the need for opioid painkillers in the first 48 hours…

This study compares two types of nerve blocks (thoracolumbar interfascial plane block and retrolaminar block) to see which one helps patients recover better after lumbar spine fusion surgery. 70 adults scheduled for surgery will receive one of the two blocks before the procedure.…

This study tests whether adding brain stimulation to spinal cord stimulation can improve leg strength and walking in adults with chronic incomplete spinal cord injury. 24 participants will receive either combined therapy or spinal stimulation alone over 16 weeks. The goal is to s…

This study tests whether adding Functional Electrical Stimulation (FES) to standard rehab can reduce leg stiffness, build muscle strength, and improve walking in people with paraplegia. Forty adults with spinal cord injury will be split into two groups: one gets rehab alone, the …

This study tests whether the drug vilamakitug can reduce symptoms of axial spondyloarthritis, a type of arthritis that causes back pain and stiffness. About 150 adults with active disease will receive either the drug or a placebo. The main goal is to see if more people get at lea…

This pilot study tests whether combining two types of non-invasive stimulation—one on the brain and one on the spine—can improve arm and hand function in people with chronic incomplete cervical spinal cord injury. 24 adults will receive either both stimulations plus rehabilitatio…

This pilot study tests whether a small device that gently stimulates a nerve in the ear can safely reduce nerve pain in people with spinal cord injury. 32 adults will use the device at home for 30 days. The main goal is to see if the treatment is practical and well-tolerated, whi…

This study looks at whether a drug called acemetacin can reduce pain and control disease activity in adults with active axial spondyloarthritis, a type of inflammatory arthritis that mainly affects the spine. About 150 people aged 18 to 65 will take a daily pill for 4 weeks. Rese…

This study tests whether electroacupuncture can improve sleep in people with long-term sciatica caused by a slipped disc. About 114 adults with chronic insomnia and leg pain will receive either real electroacupuncture or a sham version three times a week for four weeks. Researche…

This pilot study tests a new, pain-controlled rehab program for 40 adolescent soccer players (ages 14-19) with mild lumbar stress reactions. Instead of the standard 3-month sports ban, the program uses early, criteria-based activity progression. Researchers will monitor bone heal…

This study compares a specialized posture-correction exercise program (Mirror Image Spine Correction) with standard physiotherapy for adults with sciatica. Over 12 weeks, 64 participants will receive supervised sessions three times per week. The main goal is to see if the new exe…

This study compares two common back surgeries for people with lumbar spinal stenosis (a narrowing of the spine that presses on nerves). One surgery only removes the pressing bone and tissue, while the other also adds metal screws and rods to stabilize the spine. Researchers will …

This study looks at whether doing physical therapy in the daytime or evening helps people with a herniated disc in their lower back sleep better and feel less sleepy during the day. It includes 60 adults who also have a high risk for obstructive sleep apnea. Participants will be …

This study compares two types of keyhole spine surgery for middle-aged and older adults with lumbar spinal stenosis, a condition that causes leg pain and trouble walking. One surgery just removes the tissue pressing on nerves, while the other also fuses the bones together. The go…

This study compares two types of radiofrequency treatment—pulsed and conventional—for people with long-lasting tailbone pain that hasn't improved with other treatments. Ninety adults aged 18 to 80 will be randomly assigned to one of the two procedures. The goal is to see which me…

This study tests whether a gentle electrical current applied to the spinal cord (transcutaneous spinal cord stimulation) during assisted cycling can improve leg movement, reduce muscle spasms, and help bladder/bowel control in adults with incomplete spinal cord injury. Forty part…

This study tests a new AI system that adjusts electrical stimulation to the spine in real time while people with spinal cord injury walk. The goal is to improve muscle activation and walking ability compared to standard stimulation. The study involves 7 participants and focuses o…

This study compares two drugs, gabapentin and oxcarbazepine, for treating chronic nerve pain in children aged 8 to 18. Sixty participants will receive one drug or the other in a blinded fashion, with the option to switch if pain doesn't improve. The goal is to see which drug redu…

This study tests whether using virtual reality to educate patients before lumbar disc surgery reduces their anxiety more than standard education. About 56 adults scheduled for back surgery will be randomly assigned to either a VR education session or routine education. Researcher…

This study tests a home-based digital rehabilitation program combined with a non-invasive spinal cord stimulation device to improve upper limb function in people with chronic tetraplegia. Nine participants will use a mobile app-guided exercise program with daily stimulation over …

This pilot study tests whether combining non-invasive brain stimulation (over the cerebellum) with spinal cord stimulation can improve arm and hand function in people with chronic cervical spinal cord injury. Twenty-four participants will receive either both stimulations, spinal …

Chronic pain affects over 60% of people with spinal cord injuries, and standard treatments often fall short. The EmpowerSpine program is a 10-week online course that teaches pain biology, daily activity strategies, and resilience skills. This study will test 100 participants to f…

This study tests whether a continuous nerve block placed by the surgeon during back surgery can reduce pain and the need for opioids afterward. One hundred adults having lumbar spine surgery will be randomly assigned to receive either the nerve block with a numbing medicine or a …

This study looks at people with a single herniated disc in the lower back who are getting laser disc surgery. Some will also receive a steroid injection during the same procedure. Researchers will track pain, daily function, and need for more treatments to see if the extra inject…

This study tests whether an AI-powered mobile app can help people with spinal cord injury manage bowel dysfunction. About 34 adults will use the app for 12 weeks to see if it reduces bowel problem scores, shortens bathroom time, and improves quality of life. The goal is to make d…

This study compares two surgical techniques for fusing bones in the lower back: using two straight cages or one curved (banana-shaped) cage. The goal is to see which method provides better pain relief, faster recovery, and fewer complications. About 30 adults with chronic back pa…

This study tests whether a modified mini-open spine surgery (mMO-TLIF) works as well as or better than traditional open surgery for people with lumbar spinal stenosis and instability. About 224 adults aged 18 to 80 with persistent leg pain or walking problems will be randomly ass…

This study compares two needle-based treatments—electrolysis and dry needling—against standard physiotherapy for whiplash pain from car accidents. Thirty-six adults with neck pain and active trigger points will receive one of the three approaches. The goal is to see which method …

This study tests a new approach to reduce nerve pain in people with spinal cord injury. Ten participants will receive ten sessions combining mild brain stimulation (tDCS) with virtual reality walking and muscle vibration. The goal is to see if this drug-free combo can lower pain …

This study tests whether teaching patients how to move safely after lumbar stabilization surgery—using virtual reality videos and brochures before the operation—can reduce pain, anxiety, fear of movement, and fear of falling, and improve mobility. Sixty adults having their first …

This study tests whether combining loud sounds and mild electrical stimulation with walking practice can improve walking speed and leg strength in people with chronic spinal cord injury. About 20 adults with incomplete spinal injuries who can stand and have some ankle movement wi…

This study will test a new device that combines a brain-sensing headband with Apple's Vision Pro goggles to help people with ALS, brain injury, or spinal cord injury communicate. Up to 10 participants will use the system for 3-4 months to see how well they can type and control a …

This early study tests whether delivering small electrical pulses over the skin above the spinal cord, alongside standard therapy, can help people with a recent spinal cord injury regain arm and hand function. Twenty participants will receive either active or sham stimulation dur…

This study tests whether a short form of therapy called Focused Acceptance and Commitment Therapy (FACT) can help people with spinal cord injuries improve their mental health and quality of life while still in the hospital. Eight participants will complete questionnaires before a…

This study tests a robotic exoskeleton called CLINICAL EXPLORER in 60 children aged 2 to 17 with neurodevelopmental disorders like cerebral palsy. The device supports walking during 8 therapy sessions. Researchers will check if it is safe, easy to use, and helps improve movement …

Researchers at Marmara University are studying whether alexithymia, a trait where people struggle to identify and describe their feelings, relates to pain intensity, quality of life, anxiety, depression, and childhood trauma in adults with chronic coccydynia. Participants have ha…

Researchers at the University of Minnesota are studying why chronic pain varies so much from person to person. The study enrolls 400 adults with chronic low back pain or spinal cord injury-related neuropathic pain. Participants answer brief surveys four times a day for at least t…

This observational study looks at adults aged 18 to 85 with neurological conditions like stroke, Parkinson's disease, or spinal cord injury who use robotic or virtual reality tools in their rehabilitation. Researchers want to see if hope and the quality of the patient-provider re…

This pilot study will test whether temporarily stimulating nerves in the lower spine can improve movement and bladder function in one person with a spinal cord injury. The participant will have small electrodes placed near the spinal nerves and undergo 10 days of rehabilitation s…

Researchers at Assiut University are studying whether rheumatic diseases such as rheumatoid arthritis, lupus, and Sjogren's syndrome harm the meibomian glands, the tiny eyelid glands that keep tears from evaporating. The study compares 120 people with these conditions to 30 healt…

This study explores the communication challenges faced by healthcare providers when caring for non-verbal patients in intensive care, such as those with spinal cord injury or a tracheostomy. Researchers will interview nurses and speech-language pathologists, then survey a larger …

This trial tests whether an extra consultation using a predictive tool, called Dialogue Support, helps adults scheduled for lumbar spine surgery understand their likely outcomes. The tool estimates how a patient may fare one year after surgery and presents that information visual…

This observational study looks at whether the size of two lower-back muscles, the psoas and multifidus, measured on MRI scans taken before surgery, is related to how well patients recover after surgery for a herniated disc. The study will include 100 adults aged 18 to 75 schedule…

This study tracks blood sugar changes after an epidural steroid injection for back or leg pain. Researchers will compare 36 adults with and without type 2 diabetes using a continuous glucose monitor worn for 15 days. The goal is to see if the injection causes higher or longer-las…

This study will test two different levels of positive pressure (PEEP) on a breathing machine during lumbar spine surgery performed face-down. The goal is to see which setting helps patients breathe better and maintain good oxygen levels. Sixty adults aged 18-65 having elective ba…

This study looks at whether levels of a protein called 15-PGDH in the blood and joint fluid are linked to the severity of osteoarthritis and ankylosing spondylitis. Researchers will measure 15-PGDH in about 51 adults with these conditions and compare it with ultrasound images and…

This study will measure a protein called IL-41 in the blood of 90 people with ankylosing spondylitis or psoriatic arthritis, plus healthy volunteers. Researchers want to see if higher levels of this protein are linked to more active disease. The goal is to find a simple blood tes…

This study checks how consistently six doctors can grade degeneration of the small joints in the spine (facet joints) using CT scans. It includes 12 patients and uses the Pathria scale. The goal is to see if the grading method is reliable, not to test a treatment.

This study investigates whether increased muscle tone in the legs can predict neurogenic detrusor overactivity (NDO)—a condition where the bladder contracts involuntarily—in adults with upper sacral spinal cord injury. Researchers will compare medical records of 300 patients with…

This study aims to create a tool that predicts which patients are likely to have persistent pain after lumbar spine surgery, a condition known as failed back surgery syndrome. Researchers will combine routine blood tests, MRI scans, and psychological questionnaires from 150 adult…

This study looks at how different types of obesity—central (belly fat) versus peripheral (fat elsewhere)—affect blood loss and complications during major lower back surgery. Researchers will measure pressure inside the abdomen and blood loss in 90 adults having lumbar spine surge…

This observational study will follow 150 people with thoracolumbar spine fractures to see how the injury and its treatment (surgery or non-surgical care) affect joint and disc degeneration over time. Researchers will compare CT scans and pain scores between treated patients and a…

This study will test whether artificial intelligence programs like ChatGPT can interpret brain monitoring data (BIS) as accurately as experienced clinicians during spine surgery. Researchers will compare AI responses to those of two doctors in 63 patients. The goal is to see if A…

This study reviews medical records of 120 adults with low back pain who completed 15 sessions of physical therapy. Researchers will group patients based on their MRI results (disc herniation, disc degeneration, or normal findings) to see if certain types of back pain respond bett…

This study will check 45 adults with ankylosing spondylitis for peripheral neuropathy (nerve damage in the arms and legs) using nerve conduction tests. Researchers want to see if nerve problems are linked to higher disease activity, increased pain sensitivity, and worse quality o…

This study looks at how the severity of cervical spinal stenosis (narrowing of the spine in the neck) affects hand function, including grip strength and fine motor skills. Researchers will measure hand strength and dexterity in 180 adults with neck pain who have had an MRI. The g…

This study compares what happens when surgeons place a small drain in the neck after ACDF surgery versus not using one. The drain is meant to remove fluid and lower the risk of complications like bleeding or infection. About 360 adults having elective ACDF will be randomly assign…

This observational study will look at how fear of movement (kinesiophobia) relates to independence, fear of falling, pain, and mood in 70 adults with paraplegic spinal cord injury. Participants will fill out questionnaires during one visit. The goal is to better understand these …

This study looks at how quickly people with paraplegic spinal cord injury can mentally picture moving their hands or feet compared to healthy individuals. Researchers will use a computer task where participants identify left or right hand/foot images. The goal is to understand ho…

This study will check if two smartphone apps can reliably measure the curve of the spine, compared to a standard tool called a gravity inclinometer. Researchers will take measurements from 60 healthy volunteers aged 18-25, repeating them at different times to see how consistent t…

This study looks at 96 adults with lower back pain to see if the damage shown on an MRI matches how much pain they actually feel. Participants will fill out pain and disability questionnaires and get a physical exam. The goal is to help doctors better understand and treat back pa…

This observational study will follow 50 patients with primary spondylodiscitis, a serious spinal infection, for one year. Researchers will track cure rates, pain levels, and daily function using standard treatments like antibiotics and braces. The goal is to understand how well c…

This study will measure the activity of a gene called TNFAIP3 in 110 people with ankylosing spondylitis or psoriatic arthritis. The goal is to see if the gene's expression is linked to how active the disease is. Researchers will use a blood test to check gene levels and compare t…

This study will follow 120 adults receiving a steroid injection for lower back and leg pain caused by a slipped disc. Researchers want to see how factors like anxiety, pain during the procedure, and sedation affect how satisfied patients feel one hour after the injection. The goa…

This study looks at how common neck and low back pain is among full-time staff at the University of the West Indies, Mona. It also tests whether an eight-week spine-specific exercise program reduces discomfort better than a general exercise program. About 200 staff members will t…

This study will compare how massage and talk therapy affect stress and bonding hormones (cortisol and oxytocin) in people with chronic neck or back pain. Twenty-five adults with pain lasting at least 3 months will try both treatments in random order. Researchers will measure horm…

This study will look back at the medical records of 50 people with spinal cord injuries treated over the last five years. Researchers want to understand common causes of injury, levels of paralysis, and what complications patients faced, such as pressure sores or infections. The …

This observational study will measure levels of certain immune proteins (IL-17, IL-38, IL-41) and the HLA-B27 gene in 84 people with ankylosing spondylitis and a healthy control group. The goal is to see if these markers are linked to disease activity and severity. No treatment i…

This study will check if a protein called Tim-3 on certain white blood cells (neutrophils) is linked to disease activity in people with ankylosing spondylitis. Researchers will measure Tim-3 levels and compare them with inflammation markers and MRI scans of the hip and sacroiliac…

This exploratory study will use an upright MRI scanner to take 3D images of the bladder in 20 people—some with spinal cord injury who use catheters, and some healthy volunteers. The goal is to understand how the bladder and surrounding structures change shape during catheter use …

This study will follow 120 adults with sciatica from a herniated disc who receive a standard steroid injection. Researchers want to see if the speed and pattern of pain relief in the first few days and weeks can predict whether the treatment is still working at 3 and 6 months. Pa…

This study looks at how two different exercise programs—high-intensity intervals and moderate continuous activity—affect a blood marker called irisin, as well as disease activity, physical function, and quality of life in people with axial spondyloarthritis. About 75 adults with …

This study will measure harmful molecules called AGEs in 300 people with various rheumatic diseases (like rheumatoid arthritis and ankylosing spondylitis) and compare them to healthy volunteers. AGEs build up over time and can cause inflammation. Researchers will use a non-invasi…

This observational study will look at 88 people with chronic neck pain to see if the degree of cervical spine narrowing (stenosis) is linked to pain, central sensitization (an over-sensitive nervous system), movement, and quality of life. Participants will undergo pain tests, sen…

This study will observe how different spinal problems—like scoliosis, stenosis, or herniated discs—change the way people walk and use their back muscles. Researchers will compare 120 older adults (age 60+) with these conditions to healthy volunteers using motion cameras and muscl…

This study looks at whether lidocaine, a numbing medicine, changes the signals used to monitor nerves during spine surgery. 44 adults having spine surgery will get either lidocaine or a placebo. The goal is to see if lidocaine affects the nerve monitor readings, which could help …

This study will test whether 3D endoscopic visualization helps surgeons perform spine surgery tasks faster and with fewer errors compared to standard 2D vision. Six neurosurgery residents will practice on a spine model using both technologies. The goal is to see if 3D can improve…

This study compares two minimally invasive surgical techniques—uniportal and biportal endoscopy—for treating a single-level lumbar disc herniation. Sixty adults aged 18-70 with persistent symptoms will be randomly assigned to one of the two procedures. The main goal is to see whi…