Nerve-Cutting surgery could replace costly pumps for spasticity
NCT ID NCT07583277
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a surgery called selective dorsal rhizotomy to reduce severe muscle stiffness (spasticity) caused by traumatic brain or spinal cord injury. The surgery involves cutting specific nerve rootlets in the spine to relax overactive muscles. Researchers will enroll 32 people aged 4 and older to see if this one-time procedure works as well as or better than an implanted baclofen pump, which is expensive and requires ongoing maintenance.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Selective dorsal rhizotomy (a surgical procedure that cuts specific nerve rootlets to reduce muscle spasticity)
- What this could lead to
- If successful, this could offer a one-time surgical option to reduce severe muscle stiffness after brain or spinal cord injury, potentially replacing expensive implanted pumps.
- What could go wrong
- This is a small, early-stage study (32 people) with no control group, so results may not apply broadly. Surgery on spinal nerves carries risks of numbness, weakness, or loss of bladder/bowel control.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 32 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients who are four year-old and above of both sexes. * Patient with post traumatic head and / or spinal injury-induced spasticity. * Ambulant and non-ambulant patient. Exclusion Criteria: * Patient below age of four year. * Other conditions induced- spasticity e.g. Strokes, CP, MS, Hereditary spastic paresis, ALS, tumors, infections and degenerative diseases. * Patient underwent previous intrathecal baclofen pump administration.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.