Could stem cells fix your aching back? new trial tests injection after disc surgery

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age: 18-60 years old; 2. The symptoms are lumbago combined with radiating pain of one lower limb; 3. Failed conservative treatment for 3 months, including physical therapy, manual therapy and non-morphine drug therapy; 4. CT/MRI clearly highlighted the nucleus pulposus pressing the nerve root and the location was consistent; 5. Symptoms and imaging showed unilateral lumbar disc herniation; 6. Imaging showed single-level lumbar disc herniation; 7. MRI (T2WI) of Pfirrmann disc degeneration: Grade I-IV; 8. Lumbar disc herniation segments: L3-4, L4-5, L5-S1; 9. Unilateral full endoscopic extraction of nucleus pulposus; 10. Sign the informed consent; 11. No previous history of spinal surgery. Exclusion Criteria: 1. Previous history of tumor and spinal infection; 2. Patients with severe coagulation disorders, a history of drug abuse or taking oral anticoagulants; 3. Coma or incapacitation; 4. MRI contraindications (history of cardiovascular and cerebrovascular stent implantation, pacemaker, biostimulator, etc.); 5. Pregnant women; 6. Pregnancy or breastfeeding; 7. Have participated in other clinical trials related to this project within the past 30 days; 8. Those who have received stem cell therapy; 9. Poor compliance, or can not correctly understand the cooperation so that it can not complete the interview; 10. Received intervertebral disc interventional therapy within the past 3 months, such as radiofrequency, laser ablation, protease injection, Ozone injection; 11. Highly allergic or have a history of severe allergies; 12. Patients with severe autoimmune disease or who are receiving immunosuppressive therapy; 13. Serious uncontrolled infection or high fever; 14. Patients with shock, failure of vital organs and unstable vital signs; 15. X-ray showed that the degree of stenosis of the diseased segment was more than 30% compared with the adjacent normal segment; 16. Imaging showed lumbar disc herniation complicated with calcification; 17. Imaging showed lumbar disc herniation with Modic Change; 18. Imaging showed lumbar disc herniation complicated with severe spinal stenosis; 19. Imaging showed lumbar disc herniation complicated with lumbar spondylolisthesis; 20. Imaging showed lumbar disc herniation combined with spinal deformity; 21. Mental disorders, cognitive disorders, or other physical diseases affecting the research results; 22. Doctors believe that there are other reasons for not being included in the treatment.