Vein disorder

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study compares two drugs, terlipressin and somatostatin, in 64 adults with liver cirrhosis who have acute gastrointestinal bleeding and acute kidney injury. Both drugs are given intravenously for up to 5 days. The main goal is to see which drug better reverses kidney injury.…

This study tests a special stent (a small mesh tube) placed in veins to treat blockages, narrowing, or leg ulcers caused by poor blood flow. About 150 adults will receive the stent and be followed to see if it keeps the vein open and safe. The goal is to improve blood flow and re…

This study tests whether sending patients home on the same day of surgery, with follow-up care via phone calls, home visits, and a mobile app, is as safe and less costly than keeping them in the hospital overnight. The trial includes adults in Uganda having low-risk procedures su…

This study compares two surgical techniques for hemorrhoids: Doppler-guided artery ligation alone versus the same procedure combined with mucopexy (stitching up the prolapsed tissue). Researchers will measure pain levels and the sensation of incomplete evacuation (tenesmus) in 15…

This trial tests whether an absorbable gelatin sponge works as well as cyanoacrylate glue for closing off enlarged stomach veins that can bleed. Both treatments are delivered via endoscopy with small coils. Participants are adults with a history of bleeding from these veins, and …

This trial tests whether applying sucralfate—a medication that forms a protective barrier over wounds—directly onto esophageal ulcers after variceal banding can speed healing and reduce rebleeding. The study includes adults with cirrhosis who have bleeding esophageal varices. Par…

This phase 3 trial tests whether a daily tablet of CLR-07-23 (heparan sulfate) can reduce symptoms of chronic venous disease, such as leg pain, itching, swelling, and night cramps. The study includes adults aged 18 to 80 with mild to moderate vein disease. Participants take eithe…

This study looks at how surgery to fix varicocele—enlarged veins in the scrotum—affects the number of immature sperm cells in semen. Infertile men aged 20 to 45 with varicocele will have a microsurgical procedure to tie off the abnormal veins. Their semen will be tested before su…

The BRIGHT study will follow 250 adults with grade II-III hemorrhoids who are treated with a procedure called hemorrhoid artery embolization (HAE). This technique uses tiny metal coils to block blood flow to the hemorrhoids, aiming to stop bleeding without major surgery. Research…

This study tests whether treating enlarged stomach veins (gastric varices) early with a procedure called retrograde transvenous obliteration (RTO) can prevent dangerous bleeding. 68 adults with cirrhosis and gastric varices will be randomly assigned to either RTO or standard care…

This study tests a new procedure for people with a completely blocked main portal vein who have had at least two episodes of dangerous variceal bleeding. Doctors will use ultrasound to guide a needle into a vein in the gut, then try to reopen the blocked vein or create a new bypa…

This study tests whether a type of abdominal massage called visceral osteopathic manual therapy can improve sperm quality and blood flow in men with varicocele, a condition where veins in the scrotum become enlarged and can cause infertility. Thirty-two men aged 18-45 will either…

This trial tests a new device called the enVVe system, a catheter-based artificial valve placed in leg veins to treat chronic venous insufficiency. The study will enroll 220 people with severe symptoms like skin changes or leg ulcers. Participants are randomly assigned to receive…

This study tests a more thorough varicocele surgery that strips away extra veins, compared to the standard method. About 160 infertile men with varicocele will be randomly assigned to one of the two procedures. The goal is to see if the extended stripping reduces the chance of va…

This study tests whether the blood thinner rivaroxaban can safely improve outcomes in people with liver cirrhosis who have both a blood clot in the portal vein and a high risk of variceal bleeding. About 175 participants will receive rivaroxaban or standard care starting 48 hours…

This study compares a new procedure using a special stent (underdilated VCX-TIPS) with standard treatment (endoscopic banding plus beta-blockers) to prevent variceal rebleeding in people with cirrhosis. The new approach uses a smaller balloon to expand the stent, aiming to lower …

This study compares two treatments for acute deep vein thrombosis (DVT) in the leg. Half of the 104 participants will receive standard blood-thinning medication alone, while the other half will also undergo a procedure to suction out the clot, sometimes with balloon dilation or a…

This study looks at two treatments—endoscopy and a procedure called TIPS—to prevent repeat bleeding from enlarged veins in the stomach or esophagus caused by liver disease. Over 1,000 adults with this condition will be followed for a year to see which approach works better. The g…

This trial tests a new surgical technique called low excision and high suspension hemorrhoidectomy against the standard Milligan-Morgan procedure for people with severe grade III-IV mixed hemorrhoids. The study will include 120 adults who have not improved with other treatments. …

This study tests a fiber-optic navigation system that gives doctors a 3D view during a procedure called TIPS, which treats complications of liver cirrhosis like fluid buildup or bleeding. About 30 patients will be enrolled to see if the device reduces the number of needle sticks,…

This study tests whether special dressings made from donated human umbilical cord tissue, used along with standard wound care, can help close hard-to-heal leg ulcers faster than standard care alone. About 272 adults with venous leg ulcers that have not healed after 4 to 52 weeks …

This study tests whether adding colchicine, an anti-inflammatory pill, to standard blood thinners can prevent long-term vein damage after a deep vein thrombosis (DVT) in the leg. About 940 adults with a first acute DVT will receive either colchicine or a placebo for six months an…

This phase 3 trial tests whether adding albumin to standard treatment reduces re-bleeding and death in adults with cirrhosis who have acute variceal bleeding. Sixty participants will be randomly assigned to receive either albumin for three days plus standard care, or standard car…

This study tests whether using a catheter to deliver clot-busting drugs or a device to physically remove the clot can help people with acute deep vein thrombosis (DVT) who do not improve after one week of blood thinners. About 100 adults aged 18 to 75 with acute DVT in the leg wi…

This study tests a new procedure using an endoscopic ultrasound to guide the injection of tiny particles into the spleen, reducing blood flow and lowering the risk of dangerous bleeding in people with liver cirrhosis. The goal is to see if this method is safer and more effective …

This trial tests whether a new device, Pro9000X, can measure spleen stiffness to detect esophageal varices—enlarged veins in the esophagus that can bleed dangerously—in people with chronic liver disease. Currently, the only reliable way to diagnose these varices is an invasive en…

This study translates two standard questionnaires—the Hemorrhoidal Disease Symptom Score and the Short Health Scale for Hemorrhoidal Disease—into Mandarin Chinese and checks whether they are reliable and accurate for Chinese-speaking patients with hemorrhoids. About 115 adults di…

This study looks at whether non-invasive tests like blood counts and spleen size can accurately predict the presence and severity of enlarged veins in the esophagus (varices) in children with portal hypertension. Researchers will compare these simple markers to the standard metho…

This study looks at whether a special MRI scan can safely rule out high-risk varices (enlarged veins that can bleed) in people with hepatitis B-related cirrhosis. Instead of using a camera tube down the throat (endoscopy), researchers will test an MRI-based model. If it works, ma…

This study will test a new artificial intelligence (AI) system that reads eye scans (OCT) to diagnose common blinding eye diseases like diabetic retinopathy, glaucoma, and age-related macular degeneration. Researchers will collect 2000 eye scans from patients at Peking Union Medi…

This phase 3 trial tests whether vonoprazan, a newer acid-blocking drug, is better than rabeprazole at preventing ulcers and bleeding after endoscopic variceal band ligation (EVL) in people with cirrhosis. About 300 adults with esophageal varices will take one of the two drugs da…

This study compares three topical treatments—sesame oil, aloe vera gel, and nitroglycerin ointment—against no treatment for preventing phlebitis (vein inflammation) caused by chemotherapy. Researchers will enroll 190 adults with breast or colon cancer receiving specific chemo dru…

Researchers are testing a new device called the Solutio™ catheter to see if it can safely deliver numbing medicine (tumescent anesthesia) from inside the great saphenous vein before endothermal ablation, a common treatment for varicose veins. The trial enrolls 30 adults with veno…

Hemorrhoidectomy often causes severe pain, and doctors use pudendal nerve blocks to help. Researchers are testing whether a block placed higher up near the ischial spine works better than one placed lower near the perineum. Adults having elective hemorrhoid surgery receive one of…

This trial tests whether a long-acting local anesthetic, liposomal bupivacaine, provides better pain relief than the standard ropivacaine when injected around the surgical site after open hemorrhoidectomy. Adults aged 18 to 60 with grade III-IV hemorrhoids will receive one of the…

This study will test a new way to treat varicose veins using a 1940nm laser, performed outside the operating room under local anesthesia. Researchers want to see how satisfied patients are with the procedure and check its safety and effectiveness. About 155 adults with saphenous …

This study tests whether placing an ice pack inside the anal canal for one minute right after hemorrhoid removal surgery can reduce pain. Adults with severe (grade III or IV) hemorrhoids will be randomly assigned to receive either standard surgery alone or surgery plus this quick…

This study tests whether Shouhui Tongbian Capsules, a traditional Chinese herbal medicine, can relieve constipation after surgery for benign anal or rectal conditions like hemorrhoids. 120 adults will be randomly assigned to take either the herbal capsules or a standard laxative …

This study tests a new pain management system for people recovering from incarcerated mixed hemorrhoid surgery. The system includes pain medicine before surgery, traditional Chinese medicine treatments, and personalized nursing. Researchers want to see if it reduces pain and comp…

This study tests whether taking oral nifedipine, a drug usually used for high blood pressure, can reduce pain and improve wound healing after hemorrhoid removal. One hundred adults in Yemen will receive either nifedipine or a placebo twice daily for two weeks after surgery. Resea…

This study tests whether a daily herbal capsule called Nimsai Herbal can shrink hemorrhoids and reduce symptoms like pain and itching. Fifty adults with grade 2-3 hemorrhoids will take either the herbal blend or a placebo for 10 days. The main goal is to see if the hemorrhoids im…

This study tests whether using virtual reality (VR) for mindfulness can help people feel less anxious and experience less pain during minor vascular surgery done under local anesthesia. 160 adults with varicose veins will be randomly assigned to either wear VR glasses with guided…

This study looks at whether a supplement called MPFF (micronized purified flavonoid fraction) can help reduce pain and improve quality of life in adults with grade 2 or 3 hemorrhoids who are having a minor surgical procedure. About 200 participants will take MPFF as part of their…

This study compares three methods of closing the wound after hemorrhoid removal: leaving it open, stitching it closed, or stitching only half closed. About 378 adults with mixed hemorrhoids needing surgery will be randomly assigned to one of the three groups. Researchers will mea…

This study looks at the best way to treat varicose veins in the legs. It compares doing everything in one procedure versus treating the main vein first and the branch veins later. About 206 people will take part, and researchers will track how many need repeat treatment, costs, a…

This study tests whether nitroglycerin ointment, a drug often used for chest pain, can reduce pain after rubber band ligation for internal hemorrhoids. About 68 adults with grade I-III hemorrhoids will apply the ointment or a placebo three times daily for two weeks after the proc…

This study tests whether taking calcium dobesilate before and after radiofrequency ablation for varicose veins can reduce pain and improve quality of life. 250 adults with symptomatic varicose veins will be randomly assigned to receive the drug or standard care. The main goal is …

This study tests whether adding epinephrine to a glycerin and lidocaine mixture improves the treatment of small leg veins (telangiectasias). Twenty adults will have one leg treated with the standard mixture and the other with the mixture plus epinephrine. Doctors will rate vein c…

This study tests if acupuncture can lower pain and the need for painkillers after hemorrhoid removal. About 100 adults having surgery for severe hemorrhoids will get either real acupuncture or a sham version over 5 days. Researchers will track pain levels, medication use, and rec…

This study looks at whether a common procedure for varicose veins—called endovenous ablation—can also reduce knee pain in people aged 80 and older. The researchers will follow 50 participants for one year after treatment, measuring pain and knee function. The goal is to see if im…

This study compares two sedative drugs, dexmedetomidine and ketamine, given before spinal anesthesia for varicocele surgery. The goal is to see which one provides better sedation and fewer side effects. The trial will involve 58 men aged 18 to 40.

This trial tests whether protecting the anal canal during pelvic radiation can reduce hemorrhoid-related symptoms like pain, bleeding, and discomfort in cervical cancer patients. 300 women who had a hysterectomy and need radiation will be randomly assigned to standard radiation o…

This study tests whether getting more frequent phone check-ins after hemorrhoid surgery helps patients feel better and avoid problems. 116 adults who had hemorrhoid surgery will be split into two groups: one gets standard follow-up calls, the other gets extra calls. Researchers w…

This study tests whether adding methylene blue to a standard painkiller can reduce pain after hemorrhoid surgery. About 177 adults with severe hemorrhoids will receive one of two doses of methylene blue plus ropivacaine. Researchers will track pain scores, painkiller use, and qua…

This observational study will track 87 people who are already scheduled to receive treatment with the Recana Thrombectomy Catheter System for blocked veins in their legs. The goal is to see how safe the device is and how well it works at clearing the blockages during the procedur…

Superficial vein thrombosis (SVT) is a painful but usually harmless blood clot just under the skin. However, about 4% of people develop more serious clots in deep veins or lungs. Current guidelines recommend ultrasound scans to decide if blood thinners are needed, but scans are o…

This study will follow 120 women having surgery for common anal conditions like fissures, hemorrhoids, or fistulas. Researchers want to see if their sexual function improves after surgery. Participants will fill out questionnaires before surgery and at 3 and 6 months after. The g…

This observational study will test a behavioral program designed to improve how nurses and anesthesiologists handle IV catheters. Over three years, one hospital will use the program while another continues usual care. Researchers will track complications like phlebitis and infilt…

This study will follow 100 people with severe obesity who are starting a GLP-1 drug (like Ozempic or Wegovy) to see if it causes new anal or rectal problems within the first 3 months. Participants will have a check-up before starting the drug and again after 3 months to look for …

This study will follow 100 people getting a total knee replacement to see if those with chronic venous insufficiency (poor blood flow in leg veins) have more wound healing problems. Participants will have an ultrasound before surgery to check their veins and then be monitored for…

This study compares two modern teaching methods—simulation with actors and video-based learning—against traditional lectures to see which best helps nursing students recognize phlebitis (a painful vein inflammation from IVs) and make better clinical decisions. About 90 first-year…

This study looks at whether a simple, non-invasive ultrasound can predict the risk of dangerous bleeding from enlarged veins in the esophagus (varices) in people with liver cirrhosis. Researchers will measure spleen size and a key blood vessel diameter on ultrasound and compare t…

This study will test whether using a minimally invasive surgical technique for advanced hemorrhoid removal can reduce pain and speed up recovery. Fifty adults with grade III or IV hemorrhoids will undergo the procedure, and researchers will track how well the technique can be rep…

This study looks at 40 infertile men with varicoceles (enlarged veins in the scrotum) to see if blood flow measurements in the testicles can predict how well they will respond to surgery. Participants will have ultrasound and blood tests before and three months after a standard m…

This study will test a specially trained AI model (like ChatGPT) to see if it can help doctors correctly diagnose and recommend treatments for lymphedema, lipedema, and venous insufficiency. Researchers will compare the AI's suggestions to current medical guidelines. The goal is …

This study watches 300 ICU patients to see how often blood clots caused by catheters remain in the vein after the catheter is taken out. Researchers will track risk factors and whether these clots lead to serious issues like lung clots or long-term vein damage. No new treatments …

This study will follow about 2,500 adults with liver cirrhosis to learn who gets dangerous blood clots in the liver's main vein, how these clots affect survival, and whether blood-thinner medications are safe and helpful. Participants receive no experimental treatment—just routin…

This study will follow 2,500 patients with liver cirrhosis or portal hypertension who are scheduled for elective medical procedures. Researchers want to find out how often bleeding happens and what factors predict it, beyond standard blood tests. The goal is to improve safety by …

This study looks at 100 men with varicoceles (enlarged veins in the scrotum) to see if the amount of backward blood flow affects sperm quality. Participants will have ultrasound and semen tests before and 3 months after varicocele repair surgery. The goal is to better understand …

This study tests a new infusion monitoring system designed to help nurses catch complications like phlebitis, infiltration, and extravasation early in ICU patients. Researchers will compare complication rates before and after using the system in 102 patients. The goal is to see i…

This study looks at 40 people who take blood thinners (like aspirin or warfarin) and undergo radiofrequency ablation for varicose veins. Researchers will compare bleeding risks and vein closure rates over 6 months between those on blood thinners and those not. The goal is to see …

This study will follow 50 adults with varicose veins and chronic knee pain who are scheduled for standard vein treatment (laser or radiofrequency ablation). Researchers will measure changes in knee pain, stiffness, and function before and after the procedure. The goal is to see i…