Can a plant compound soothe post-surgery hemorrhoid pain?
NCT ID NCT07647172
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether a supplement called MPFF (micronized purified flavonoid fraction) can help reduce pain and improve quality of life in adults with grade 2 or 3 hemorrhoids who are having a minor surgical procedure. About 200 participants will take MPFF as part of their standard care. The main goal is to measure changes in pain levels one week after surgery.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 200 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Apr 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
patients with haemorrhoids undergoing minimally invasive surgical interventions
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Males and females aged over 18 years. * Informing the patient in writing about the inclusion in the study and his/her consent to participate in it. * Absence of conditions requiring urgent medical care. * The patient was diagnosed with chronic hemorrhoids of grade 2 or 3 according to Goligher classification. * The patient is scheduled to undergo one of the listed types of minimally invasive surgical treatment within 7 ± 2 days from the inclusion in the study (V0): * laser vaporization (laser submucosal destruction or ablation); * transanal dearterialization (hemorrhoidal artery ligation); * transanal dearterialization + laser vaporization (laser submucosal destruction or ablation); * transanal dearterialization + sclerotherapy. * No venoactive drug treatment within 4 weeks prior to inclusion in the study. * The patient has been prescribed with MPFF at the inclusion visit, or it is planned to prescribe MPFF-containing drug in the postoperative period (for cluster 1 sites), or the patient has not been prescribed with any systemic venoactive drug, and it is not planned to prescribe it the postoperative period (for cluster 2 sites).\* Exclusion Criteria: * Pregnancy or breast-feeding, or planning for pregnancy during the study or at least in two months after its completion. * Confirmed or suspected malignancy. * Severe somatic disorder (of heart or blood vessels, lungs, kidneys, pancreas, or liver), accompanied by the organ function decompensation. * Mental disorder. * Contraindications for examination. * Predicted unwillingness of the patient to follow the protocol of treatment and supervision, poor adherence to treatment. * Patient's participation in any interventional/observational study at the present time. * Patients who received venoactive drugs in the 4 weeks prior to Visit 0 (inclusion visit).
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Conditions
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As listed by the trial registrant
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