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Could a heart drug ointment soothe hemorrhoid pain?

NCT ID NCT07391501

Symptom relief Sponsor: Ying Zhu Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether nitroglycerin ointment, a drug often used for chest pain, can reduce pain after rubber band ligation for internal hemorrhoids. About 68 adults with grade I-III hemorrhoids will apply the ointment or a placebo three times daily for two weeks after the procedure. The main goal is to see if fewer people need rescue pain medication within 72 hours.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nitroglycerin ointment
What this could lead to
If it works, this could provide a simple, safe way to ease pain after a common hemorrhoid procedure, reducing the need for extra painkillers.
What could go wrong
This is a small, early-phase trial. The ointment may not work better than placebo, and side effects like headache or low blood pressure are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 68 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Nov 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: 18 to 75 years, male or female * Diagnosis/indication: Internal hemorrhoids grade I, II, or III scheduled for endoscopic rubber band ligation * Consent: Able and willing to participate and provide written informed consent Exclusion Criteria: * Compliance/assessment: Unable to understand study endpoints or complete study records/forms * Concomitant medications: Current use of oral nitrates or calcium channel blockers * Allergy: Known allergy to lactulose oral solution, nitroglycerin ointment, or other study-related medications * Pregnancy/lactation: Pregnant or breastfeeding women * Procedure tolerance: Unable to tolerate hemorrhoid band ligation, colonoscopy, or bowel preparation * Severe comorbidities: Severe cardiac, respiratory, neurologic, or psychiatric disorders * Legal capacity: Lacking legal capacity for civil conduct or lacking insight/judgment to provide valid consent

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Conditions

The condition(s) this trial relates to.

internal hemorrhoid Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Internal hemorrhoids Postoperative pain after endoscopic rubber band ligation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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