Vein disorder

Researchers are testing a new adhesive system that seals the great saphenous vein in people with varicose veins. The trial compares this adhesive, delivered through a tube, with radiofrequency ablation, a standard treatment that uses heat to close the vein. About 179 adults with …

This trial asks whether adding ozone gel to ultrasound treatment helps chronic venous leg ulcers heal better than either treatment alone. Venous leg ulcers are open sores that occur when leg veins fail to return blood to the heart, and they can be slow to heal. Researchers will c…

This trial tests whether a personalized tissue-engineered vein, made in the lab with a functioning valve, can safely replace a damaged vein segment in people with severe chronic venous insufficiency. Each participant undergoes surgery to swap a non-working valve in their femoral …

This early-stage study tests a new drug called EYE201, given as three eye injections over 12 weeks, to see if it is safe and can help reduce swelling in the back of the eye. It includes people with three different eye conditions that cause vision loss: branch retinal vein occlusi…

This trial tests whether a special catheter protector, called I.V. House UltraDressing, can help peripheral IV catheters stay in place longer and cause fewer complications in adult cancer patients. Participants are randomly assigned to receive either the standard transparent dres…

This early-stage trial is testing whether a single topical application of FGF-1, a protein that helps cells grow, is safe for people with diabetic or venous stasis ulcers. The study enrolls a small group of adults with full-thickness leg ulcers that have lasted at least 8 weeks. …

This trial tests whether microscopic surgery to repair varicoceles (enlarged veins in the scrotum) works better than antioxidant medication for men with cryptozoospermia—a condition where very few sperm are present in semen. About 69 men with clinical varicoceles will be randomly…

This trial tests whether adding vacuum compression therapy — a device that applies cycles of pressure and suction to the leg — can improve healing of chronic lower limb ulcers. Adults with ulcers that have not healed despite standard care will receive either standard wound care a…

This study tests the safety of an experimental eye injection called ONS-5010 (bevacizumab) in people with vision loss from wet age-related macular degeneration, diabetic macular edema, or branch retinal vein occlusion. Participants receive the injection and are monitored for side…

This study tested a higher dose (8 mg) of the drug aflibercept against the standard dose (2 mg) in 892 adults with macular edema from a blocked retinal vein. The goal was to see if the higher dose works as well or better while allowing fewer injections. Participants received inje…

This study looked at two common treatments for grade I-III internal hemorrhoids: injection sclerotherapy and rubber band ligation. Researchers followed 984 patients across multiple hospitals to see which treatment worked better and had fewer side effects. The goal is to help doct…

This study tested a new way to treat venous leg ulcers, which are slow-healing wounds on the lower leg. Researchers used ultrasound to push hyaluronic acid gel into the wound and compared it to standard care in 64 patients. The goal was to see if this combination speeds up healin…

This study looked at whether giving antibiotics before an endoscopic procedure helps prevent fever and rebleeding in people with cirrhosis who have had variceal bleeding before. 226 patients were randomly assigned to receive the antibiotic ceftriaxone or no antibiotics before the…

This study tested a special bandage (dressing) that contains a germ-killing ingredient called chlorhexidine for IV tubes placed in the arm. The goal was to see if it reduces infections and other complications compared to the standard bandage. About 300 patients in Australia and F…

This study tested whether a pre-filled syringe of the medicine SB11 (a biosimilar to ranibizumab) is easy for eye doctors to use. Thirty adults with wet age-related macular degeneration, macular edema from retinal vein occlusion, or myopic choroidal neovascularization received on…

This study tested a combination of proton beam radiotherapy followed by two drugs (Tecentriq and Avastin) in 63 adults with advanced liver cancer that had spread into the portal vein. The goal was to see if this approach could help control the cancer and improve survival. Partici…

This study tested whether a special blood test (ROTEM) can better guide blood transfusions in people with acute-on-chronic liver failure who are bleeding from enlarged veins. 262 participants were randomly assigned to receive transfusions based on either the new test or standard …

This study tested a special wound dressing called MicroMatrix Flex on 25 adults with deep or tunneled wounds, such as pressure injuries, diabetic ulcers, or infected wounds. The goal was to see how safely and quickly the dressing helped close these wounds over 12 weeks. Researche…

This study tested a three-drug combination for people with advanced liver cancer that has spread into the portal vein (a major blood vessel). The treatment adds a liver-directed chemotherapy infusion to two standard drugs (lenvatinib and a PD-1 inhibitor). The goal was to see if …

This study compared open surgery versus laparoscopic (keyhole) surgery for varicocele, a condition where veins around the testicle become enlarged. 100 men aged 20–60 were randomly assigned to one of the two procedures. Researchers measured how long the operation took, how many d…

This study tested two surgical methods to repair varicoceles (enlarged veins in the scrotum) in 60 men with fertility issues or pain. One group had a loupe-assisted surgery with a nitroglycerin spray to help see blood vessels, while the other had standard microscopic surgery. The…

This study tested a new medicine called 601 against an existing drug, ranibizumab, for people with vision loss due to a blocked vein in the eye (branch retinal vein occlusion). 351 adults received injections into the eye to reduce swelling and improve sight. The goal was to see i…

This study tested a device called the JETi system to remove blood clots from veins or arteries in the arms or legs. It included 12 adults of Asian descent in Hong Kong. The goal was to see how well the device cleared clots and if it caused serious side effects like bleeding or re…

This phase 2b trial tested a one-time application of a cell therapy made from donor skin cells (Allo-APZ2-CVU) in 159 people with chronic venous leg ulcers that hadn't healed despite standard care. The goal was to see if it could shrink or close these wounds better than a placebo…

This study tested a new method called SALFOAM 3% for treating varicose veins in the legs. It involved 35 adults and compared the new method to the standard foam treatment. The goal was to see if the new method closes veins better and causes less skin darkening.

This study looked at whether adding a dexamethasone implant (Ozurdex) to standard bevacizumab (Avastin) eye injections could reduce the number of injections needed for people with non-ischemic central retinal vein occlusion. Sixty-eight participants received either Avastin plus a…

This study tested a new way to treat severe blood clots in the portal vein during liver transplant surgery. Doctors used a special approach through a ligament in the donor liver to place stents or close off abnormal veins. The study included 75 patients and found the method safe …

This study is testing whether a new type of MRI (4D flow MRI) can detect dangerous veins in the stomach and esophagus of people with cirrhosis, which can cause fatal bleeding. Currently, doctors use a camera down the throat (endoscopy) to check, but that is invasive and often unn…

This study tested whether an AI app (IVENUS) could correctly classify the severity of chronic vein disease from leg photos. Over 1,600 patients had their legs photographed, and the app's diagnosis was compared to that of experienced doctors. The goal was to see if the app could r…

This study tested a new questionnaire (HDQ) to help diagnose hemorrhoids in Russia. Researchers enrolled 725 adults visiting a coloproctologist. The goal was to see how well the questionnaire identifies hemorrhoids compared to a doctor's exam, aiming to improve screening and pati…

This study tested whether a wired magnetic capsule endoscopy system produces fewer airborne droplets than traditional endoscopy when checking for esophageal varices in people with biliary atresia. Fifty participants underwent either the capsule or standard procedure. The main goa…

This study looked at whether giving family doctors a small, portable ultrasound machine helps them diagnose and manage eight common conditions (like pneumonia, kidney stones, and pregnancy issues) without needing extra tests. Over 160 patients took part, and researchers compared …

This study tested a device called Insight Pro to see if it can safely detect lymphatic and vein disorders, such as lymphedema and chronic venous insufficiency. The device measures fluid buildup and skin hardness in the arms or legs. A total of 67 adults with or without these cond…

This study tested a new imaging device called OCT angiography (OCTA) that takes 3D pictures of blood vessels in the back of the eye without needing dye injections. Researchers compared OCTA images to standard dye-based imaging in 88 people with retinal blood vessel problems or no…

This clinical trial investigates whether two existing medications, allopurinol and atorvastatin, can help prevent serious complications in people with stable liver cirrhosis. The study will compare these drugs against a placebo to see if they reduce the number of acute decompensa…

This trial tests whether a short 5-day course of the blood thinners rivaroxaban (Xarelto) or apixaban (Eliquis) can prevent blood clots that sometimes form after laser treatment for varicose veins. Adults with symptomatic vein reflux undergoing laser ablation of the great sapheno…

This study tested a care bundle—a set of steps including nurse training, hand washing, and special cleaning solutions—to prevent IV-related problems like swelling and vein inflammation in children. Researchers compared 200 kids in the emergency department who either got the care …

This study tests a special adhesive patch made with zinc oxide to hold catheters (thin tubes placed in veins) in place for hospitalized adults. The goal is to see if it reduces complications like the catheter moving, skin irritation, vein swelling, and pain. About 400 patients wh…

Researchers are testing whether applying ice around an intravenous catheter before an oxacillin injection can lower pain and reduce peripheral phlebitis, an inflammation of the vein. The trial enrolls 86 hospitalized adults aged 20 to 60 who receive oxacillin through a hand vein.…

This completed study looked at 200 adults having hemorrhoid surgery. Half also had a small cut in a muscle around the anus (lateral internal sphincterotomy). Researchers measured pain and accidental leakage of gas or stool after surgery. The goal was to see if the extra cut helps…

This trial tests whether a structured nursing program—including education before the procedure, support during it, and follow-up calls—can improve symptoms and quality of life for people with chronic venous disease undergoing foam sclerotherapy. Participants are randomly assigned…

This study compares two sizes of IV cannulas (18-gauge vs 20-gauge) in emergency patients to see if the larger one causes more pain or is harder to insert. About 204 adults with low-to-moderate difficulty for IV access will be randomly assigned to one size. Patients will wear gog…

This study tests two medications, dexmedetomidine and tramadol, given before hemorrhoid surgery to see which one better reduces anxiety and pain. Ninety adults will receive one of the drugs or a placebo before spinal anesthesia. Researchers will measure anxiety levels and pain sc…

This trial tests whether a topical ointment containing two numbing agents (lidocaine and tetracaine) can reduce pain after hemorrhoid surgery. Adults scheduled for elective hemorrhoidectomy will apply the ointment or a placebo every 12 hours for 10 days after surgery. Researchers…

This trial compares a newer, minimally invasive laser procedure to standard surgery for grade II and III hemorrhoids. The laser technique aims to shrink hemorrhoid tissue with less pain and faster recovery. Researchers will measure postoperative pain, patient satisfaction, and ho…

This study compared two common treatments for second-degree hemorrhoids: injection sclerotherapy and rubber band ligation. Researchers looked at how well each method stopped bleeding and worked overall. The study involved 128 adults aged 18 to 75 with second-degree hemorrhoids.

This study tested a new, standardized process for providing assistive devices (like special tools) to help people put on and take off compression stockings. 220 adults who need these stockings long-term took part. The goal was to see if the new method improves how often people us…

This study tested two creams for painful hemorrhoids: carraghenates cream and Mayinglong musk hemorrhoid ointment. 123 participants used one of the creams twice daily for 6 days. Researchers measured how quickly pain eased and how well symptoms like bleeding and swelling improved…

This study looked at two surgical approaches for varicose veins: removing the main faulty vein and the visible varicose veins all at once, or removing just the main vein first and the varicose veins later. Researchers wanted to see which approach leads to better symptom relief an…

This study tested a dietary supplement containing diosmin, hesperidin, bromelain, and ruscus aculeatus in 80 adults with early signs of chronic venous disease, like heavy or swollen legs. Participants took the supplement for 12 weeks, and researchers measured changes in quality o…

This study tested a new, minimally invasive procedure for people with grade II or III hemorrhoids. Instead of surgery, doctors used tiny coils to block the main artery supplying blood to the hemorrhoids, aiming to shrink them and reduce pain. The study included 26 participants an…

This study compared two surgical treatments for grade III hemorrhoids: open hemorrhoidectomy and transanal hemorrhoidal desarterialization (THD). Fifty adults were randomly assigned to one of the two procedures and tracked for a year. The main goal was to see which surgery better…

This study compared two ways to numb the leg for outpatient vein ablation surgery: a femoral nerve block (injecting lidocaine near the groin) and low-dose spinal anesthesia (injecting bupivacaine into the spine). Forty adults aged 18-80 with mild to moderate health status took pa…

This study tested whether a mild electrical stimulation at specific acupoints (TEAS) helps people with cirrhosis tolerate an urgent endoscopy for suspected variceal bleeding. 180 patients were split into three groups: active TEAS, sham TEAS (electrodes but no current), or standar…

This study looked at 90 adults with severe prolapsed hemorrhoids to compare three surgical techniques: traditional surgery, a stapling device, and a vessel-sealing device. The main goal was to measure pain after surgery and track complications like bleeding or urine retention. Th…

This study tested two ways of applying compression bandages for venous leg ulcers: one that covers the heel and one that leaves it uncovered. Researchers measured the pressure under the bandage and checked ankle swelling in 102 patients. The goal was to see if leaving the heel ou…

This study tested a wearable compression device called Dayspring for people with lymphedema in one leg. 24 adults used the device daily for 3 months. Researchers measured changes in leg swelling and quality of life to see if the device was safe and helpful.

This completed trial tested a medical device cream called PROCTOeze® PLUS in 50 adults with mild to moderate hemorrhoids (Grade I-II). Participants applied the cream at home for 14 days to see if it improved symptoms and quality of life. The study measured changes using a short h…

This study tested whether a herbal capsule called Trĩ Thiên Dược can stop bleeding from grade II internal hemorrhoids better than a standard drug (diosmin). 172 adults with bleeding hemorrhoids took either the herbal capsule or diosmin for 28 days, then were followed for another …

This study looked at how well phlebotonics—drugs that strengthen blood vessels and reduce swelling—help people with mild to moderate hemorrhoids. Researchers tracked 131 Italian patients with symptoms like bleeding and pain. The goal was to see if these drugs improve quality of l…

This study looked at whether numbing the anal area with an injection of ropivacaine is necessary during a newer, less invasive radiofrequency procedure for hemorrhoids. 134 adults having this procedure were randomly assigned to receive the injection or not. The main goal was to s…

This study tested whether adding a small cut to relax the anal muscle during standard hemorrhoid surgery helps reduce pain and bleeding after the operation. 120 adults with advanced hemorrhoids were randomly assigned to get either the standard surgery or the surgery with the extr…

This completed study tested a tablet containing horse chestnut, smartweed, sarsaparilla, and rutin in 120 adults with mild to moderate hemorrhoids. Over 60 days, researchers measured changes in symptoms like pain, bleeding, and itching using a symptom score. The goal was to see i…

This study tested whether a combination of herbal ingredients (horse chestnut, polygonum acre, smilax pepyracea, and rutin) works as well as a standard drug (diosmin and hesperidin) for easing leg symptoms from chronic venous insufficiency. 120 adults with mild to moderate vein d…

This study tested a new portable, non-pneumatic compression device (Dayspring) against a standard pneumatic compression device for treating leg lymphedema. 121 adults with leg swelling used each device for three months, with a month off in between. Researchers measured changes in…

This study tested whether sleeping with a special leg-elevation device (UZit®) can ease symptoms of chronic venous disease, a condition where leg veins have trouble moving blood back to the heart. Seventeen adults used the device every night for one week. Researchers measured cha…

This study looked at placing a small metal tube (stent) into the portal vein of 63 cancer patients whose vein was blocked by a tumor. The goal was to relieve serious symptoms like fluid buildup in the belly or bleeding in the gut. The procedure was done through a needle in the li…

This study tested whether special insoles called Light Legs can improve blood flow in the legs (venous return) and quality of life in people with vein problems. Fifty-four adults used the insoles for 14 days and filled out questionnaires about their symptoms and how easy the inso…

This study tested a treatment called Complex Decongestive Therapy (CDT) for people with venous insufficiency, a condition where leg veins struggle to send blood back to the heart. Twenty-one adults received either CDT plus exercises or exercises alone. The goal was to see if CDT …

This study looked at whether a special interactive dressing (UrgoStart Plus) used with compression bandages can help heal venous leg ulcers faster than standard dressings. Sixty adults with chronic leg ulcers were treated for up to 12 weeks. The goal was to see if the new dressin…

This study looked at whether applying ice packs for 10 minutes after hemorrhoid surgery helps reduce pain and the need for strong painkillers. Researchers compared 429 patients who either received ice packing or standard care. The goal was to see if this simple, low-cost method c…

This study tests whether releasing a blood pressure cuff (used as a tourniquet) early during blood collection reduces the rate of hemolysis — when red blood cells burst and ruin the sample. About 792 emergency department patients with non-critical conditions will be randomly assi…

This study investigates whether people with chronic venous insufficiency—a condition where leg veins struggle to return blood to the heart—experience more swelling, pain, and weakness than healthy people. Researchers will measure breathing muscle strength, lung function, walking …

This study tested whether a special PET/CT scan can predict which patients with deep vein thrombosis (DVT) will later develop post-thrombotic syndrome (PTS), a condition causing chronic leg pain, swelling, and ulcers. Researchers imaged 51 patients shortly after their DVT and fol…

This study explores whether using minimally invasive surgery tools during standard hemorrhoid removal can reduce pain and speed up recovery. It involves a small group of adults with grade III hemorrhoids who are scheduled for surgery. The main goal is to see if the technique is t…

This study looks at whether levels of a protein called zonulin, found in blood and semen, differ between infertile men with and without varicocele (enlarged veins in the scrotum). Researchers will measure zonulin in 119 men and compare it with standard semen quality measures like…

This study watches and records pain levels at four key moments during radiofrequency ablation for varicose veins—from needle insertion to the end of the procedure. Researchers will look at how factors like age, gender, and body mass index relate to pain. The goal is to find patte…

This study looked at 480 cirrhosis patients who had variceal bleeding and were getting an endoscopy to prevent future bleeding. Half got antibiotics before the procedure, half did not. The goal was to see if antibiotics reduce infections after the procedure. The study is retrospe…

This study looked at 412 people with cirrhosis who had bleeding from veins in the esophagus or stomach. Half got an endoscopy within 6 hours, the other half between 6 and 24 hours. The goal was to see if faster treatment lowered the chance of rebleeding within 42 days. The result…

This study looks at how radiation therapy for brain tumors like meningioma or pituitary adenoma might affect autobiographical memory—the memories of your life events. Researchers will ask 17 patients to complete memory tests one and two years after treatment. The goal is to see i…

This study tested whether a computer program (Simcyp) could help doctors choose the right starting dose of warfarin, a blood thinner, for 21 patients with liver cirrhosis and a blood clot in the portal vein. The goal was to see if the program helped patients reach a safe, effecti…

This study looked at 40 adults undergoing radiofrequency ablation for varicose veins to compare two types of regional anesthesia: spinal anesthesia and a fascia iliaca block. The goal was to see which method leads to better recovery quality, less pain, and faster mobility after t…

This study tested how different levels of leg compression affect blood circulation in 30 adults after surgery. Participants received three pressure levels (low, moderate, high) on their calves, and blood flow was measured non-invasively. The goal is to gather early evidence for m…

This study looked at how much of a burden patients feel from repeated anti-VEGF eye injections for three different eye diseases: wet age-related macular degeneration, retinal vein occlusion, and diabetic macular edema. Researchers surveyed 393 patients about their treatment burde…

This completed study looked at 26,000 patients who had outpatient procedures for blood vessel problems like peripheral artery disease, varicose veins, or dialysis access issues. The goal was to see how safe and effective these procedures are when done in an office-based angiosuit…

This study explores the experiences of 20 intensive care nurses in managing phlebitis, a painful vein inflammation often caused by IV lines. Through face-to-face interviews, researchers aim to uncover common challenges and helpful strategies. The goal is to improve prevention and…

This study tested a new way to measure blood pressure in stomach veins of 25 people with liver cirrhosis and enlarged veins (varices). Doctors used an endoscope with ultrasound to see if this method could better predict bleeding risk than standard tests. The goal was to see if th…

This study looked at whether combined oral contraceptives (birth control pills) influence the development or worsening of chronic venous diseases, like varicose veins. Researchers followed 116 women taking different types of birth control pills. The goal was to see if these pills…

This study compared two types of IV catheters—closed and open—in 100 patients in a respiratory intensive care unit. The goal was to see which type stays functional longer without complications like thrombophlebitis. Researchers measured dwell time and catheter-related issues to f…

This study looked at 360,000 French patients who received eye injections for conditions like age-related macular degeneration. The goal was to find out how often a serious eye infection called endophthalmitis happens within 28 days after the injection. Researchers analyzed data f…

This study looked at whether measuring liver pressure during an endoscopy is more accurate when patients lie on their left side versus flat on their back. Researchers tested 30 hospitalized patients with liver cirrhosis. The goal was to see if the two positions give consistent re…

This completed study examined how to best manage early-stage upper gastrointestinal cancer in patients who also have liver cirrhosis and enlarged veins in the esophagus (varices). Researchers compared outcomes of a keyhole-like endoscopic surgery (ESD) between 206 patients with a…

This study looked at 650 Brazilian patients with chronic venous disease (CVD), a condition that causes leg swelling, skin changes, and ulcers due to faulty veins. Researchers collected data on risk factors like obesity and smoking, other health problems, and treatments used. The …

This study tested a new ultrasound device to measure skin stiffness (fibrosis) in people with lymphedema or venous insufficiency. Researchers compared results from 130 participants, including healthy volunteers, to see if the device could detect differences in skin hardness. The …

This study tested a new sensor (CIMON) to see if it can accurately measure how well compression bandages reduce leg swelling in people with chronic edema (long-term fluid buildup). Fifty-two adults with leg swelling who needed compression bandages took part. The sensor was placed…

This study looked at whether measuring the inferior vena cava through the liver (transhepatic approach) can predict if a patient needs more fluids after heart surgery. 40 ICU patients were included. The goal was to avoid giving too much fluid, which can be harmful. The study comp…

This study looked at how compression stockings of different strengths change the size and pressure of leg veins in people with chronic venous insufficiency and healthy volunteers. Researchers measured vein diameter and leg pressure while participants stood, sat, or lay down. The …

This study tested a decision-support tool called DOACT that helps doctors choose the right blood thinner for patients with blood clots in veins or lungs. Researchers compared how well the tool performed against artificial intelligence models and doctors' own judgment. The goal wa…

This study looked at over 550,000 people who received Eylea® injections for eye conditions to find out how often retinal vasculitis (a rare eye inflammation) occurs. Researchers used a large US registry and medical records to confirm cases. The goal was to better understand the s…