Birth control pills under scrutiny for vein disease link
NCT ID NCT04451746
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether combined oral contraceptives (birth control pills) influence the development or worsening of chronic venous diseases, like varicose veins. Researchers followed 116 women taking different types of birth control pills. The goal was to see if these pills are linked to vein problems or deep vein thrombosis.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- combined oral contraceptives (birth control pills)
- What this could lead to
- If results are clear, this could help doctors understand whether birth control pills influence vein health and guide safer prescribing.
- What could go wrong
- This is a small, completed observational study, not a controlled trial. It cannot prove cause and effect, and findings may not apply to all women.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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116 people
The number who actually took part.
- Started
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Jun 2020
- Finished
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Feb 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. The investigators consistently include patients who have been prescribed hormonal tablets for contraception, namely 1) COCs with bioidentical estrogen; 2) COCs with ethinyl estradiol 30mkg according to the scheme 21 + 7; 3) COCs with ethinyl estradiol 20mkg according to the scheme 21 + 7. 2. Clinical class C0-1 according to CEAP; 2\) Able to come for checkups every 3 months; 3) The presence of informed consent. Exclusion Criteria: 1. Age up to 45 years; 2. A history of surgical treatment of veins of the lower extremities; 3. Clinical class C2 and higher according to CEAP; 4. History of DVT or PE; 5. Aplasia or angio-dysplasia of deep veins; 6. Restriction of mobility; 7. Arterial insufficiency; 8. Oncological diseases.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Clinic of phlebology and laser surgery
Chelyabinsk, 454090, Russia