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Can fixing a varicocele beat antioxidants for boosting sperm?

NCT ID NCT07759713

Disease control Sponsor: Sohag University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial tests whether microscopic surgery to repair varicoceles (enlarged veins in the scrotum) works better than antioxidant medication for men with cryptozoospermia—a condition where very few sperm are present in semen. About 69 men with clinical varicoceles will be randomly assigned to one of the two treatments. Researchers will measure sperm concentration at 6 and 12 months, and also track biological pregnancy and live birth rates to see which approach offers a better chance of fathering a child.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Microscopic varicocele surgery (varicocelectomy) compared with antioxidant medication
What this could lead to
If successful, this could identify a better first-line treatment to improve sperm counts and increase chances of natural conception or IVF success in men with cryptozoospermia.
What could go wrong
This is a small trial (69 participants) and results may not apply to all men. Surgery carries standard procedural risks, and antioxidants may not improve fertility in every case.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

69 people

The number who actually took part.

Started

Feb 2024

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male Infertility with cryptozoospermia and clinical varicoceles Exclusion Criteria: * Genetic abnormalities. Other causes of male infertility

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Conditions

The condition(s) this trial relates to.

oligospermia varicocele

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cryptozoospermia

Contacts and locations

Locations

  • Andrology department

    Qina, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.