Can a vacuum chamber help heal stubborn leg wounds?
NCT ID NCT07737184
First seen Jul 30, 2026 · Last updated Aug 04, 2026 · Updated 3 times
Summary
This trial tests whether adding vacuum compression therapy — a device that applies cycles of pressure and suction to the leg — can improve healing of chronic lower limb ulcers. Adults with ulcers that have not healed despite standard care will receive either standard wound care alone or standard care plus 12 sessions of vacuum therapy over four weeks. Researchers will measure changes in wound size, pain, tissue oxygen levels, and quality of life to see if the added treatment makes a difference.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a device that applies alternating positive and negative pressure to the leg inside a sealed chamber
- What this could lead to
- If it works, this could offer a non-drug way to speed up healing of stubborn leg ulcers and improve patients' quality of life.
- What could go wrong
- This is a small, early-stage trial with only 50 participants, so results may not apply to everyone. The therapy requires multiple clinic visits and may not be comfortable for all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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50 people
The number who actually took part.
- Started
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Jul 2024
- Finished
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Dec 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * adult patients (≥18 years) with chronic lower limb ulcers of ischemic, venous, diabetic, or post-traumatic etiology that had persisted despite appropriate standard therapy and showed no significant signs of healing progression over a one-month period Exclusion Criteria: * age under 18 years, * inability to cooperate with study procedures, * clinically significant infection requiring systemic antibiotic therapy, * active oncological disease, severe uncontrolled pain, and * any contraindications to vacuum compression therapy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Dermatology, University Hospital Ostrava
Ostrava, Czechia, 708 52, Czechia
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Other studies related to the condition(s) this trial covers.
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