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Natural blend may soothe hemorrhoid pain, study finds

NCT ID NCT06705777

Symptom relief Sponsor: Fundação Educacional Serra dos Órgãos Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This completed study tested a tablet containing horse chestnut, smartweed, sarsaparilla, and rutin in 120 adults with mild to moderate hemorrhoids. Over 60 days, researchers measured changes in symptoms like pain, bleeding, and itching using a symptom score. The goal was to see if this herbal combination could improve comfort and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A combination of horse chestnut, smartweed, sarsaparilla, and rutin in tablet form
What this could lead to
If it works, this could offer a natural option to ease hemorrhoid symptoms like pain, itching, and bleeding.
What could go wrong
This is a small, completed Phase 4 trial with 120 people, so results may not apply to everyone. Herbal supplements can have side effects or interact with other medications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

120 people

The number who actually took part.

Started

Sep 2024

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Grade 1, 2 or 3 hemorrhoidal disease * Complaints related to haemorrhoidal disease/acute hemorrhoidal crisis (defined as acute anal pain due to haemorrhoidal prolapse with or without bleeding, edema and thrombosis) * For female patients of reproductive age, not pregnant or breastfeeding, using reliable contraception. * Patient has read, understood, signed and dated the informed consent form Exclusion Criteria: * Presence of concomitant severe systemic disorders * Treatment with venotonics within 2 months of the date of inclusion in the study * Women of reproductive age who are pregnant or breastfeeding, or who do not wish to use contraception during the study period. * Known allergy or hypersensitivity to any component of the study medication * Known significant laboratory abnormality * Anal fissure * Inflammatory bowel disease * Colorectal cancer * Anal abscess or fistula * Previous anorectal surgery and/or radiotherapy in the pelvic-perineal region * Patient with a change in general condition that is incompatible with her participation in the study * Patient who wishes to become pregnant within 6 months * Inability of the patient to understand the nature of the study and follow the doctor's recommendations

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Conditions

The condition(s) this trial relates to.

hemorrhoid

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Haemorrhoidal disease

Contacts and locations

Locations

  • Centro Universitário Serra dos Órgãos - UNIFESO

    Teresópolis, Rio de Janeiro, 25964004, Brazil

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