Antibiotics before endoscopy: do they prevent infections in liver patients?
NCT ID NCT07616466
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at 480 cirrhosis patients who had variceal bleeding and were getting an endoscopy to prevent future bleeding. Half got antibiotics before the procedure, half did not. The goal was to see if antibiotics reduce infections after the procedure. The study is retrospective, meaning it looked back at past records, so it can't prove cause and effect.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ceftriaxone (an antibiotic)
- What this could lead to
- If it works, this could clarify whether antibiotics are needed before endoscopy to prevent infections in cirrhosis patients.
- What could go wrong
- This is a retrospective study, not a controlled trial, so results may be less reliable. It also only looks at short-term outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
480 people
The number who actually took part.
- Started
-
Jan 2024
- Finished
-
Mar 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Cirrhotic patients with a history of gastroesophageal variceal bleeding and were readmitted for elective endoscopic treatment.
- Ages
-
18 to 80 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Cirrhotic patients with a history of gastroesophageal variceal bleeding who were readmitted for elective endoscopic treatment. Exclusion Criteria: * (1) Age \< 18 or ≥ 81 years; (2) Allergy to cephalosporin; (3) Agranulocytosis (neutrophil count \< 0.5 × 10\^9/L); (4) Massive ascites; and (5) Signs of bacteria infection. Withdraw Criteria:（1）Transferred to other department for additional treatment after the endoscopic operation (Surgical department for malignant tumor, Interventional radiology department for splenic embolism or transjugular intrahepatic portosystemic shunt, etc.). （2）Lost to follow-up
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China
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