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New needle route may stop deadly bleeding in clogged portal veins

NCT ID NCT07666256

Disease control Sponsor: Air Force Military Medical University, China Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new procedure for people with a completely blocked main portal vein who have had at least two episodes of dangerous variceal bleeding. Doctors will use ultrasound to guide a needle into a vein in the gut, then try to reopen the blocked vein or create a new bypass to lower pressure. Only 15 participants will be enrolled, and the main goals are to see if the procedure works and how safe it is.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Percutaneous mesenteric vein puncture procedure
What this could lead to
If successful, this procedure could offer a new treatment option for patients with blocked portal veins who have few alternatives to stop life-threatening variceal bleeding.
What could go wrong
This is a very small, early study (15 people) with no control group. The procedure carries risks like internal bleeding or bowel injury, and it may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria 1. Confirmed OPVT, as demonstrated by contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI). 2. History of at least two episodes of esophagogastric variceal bleeding. 3. Ineligible for, or have previously failed, conventional transjugular intrahepatic portosystemic shunt (TIPS) or percutaneous transhepatic/transsplenic access approaches, including but not limited to extensive thrombosis of intrahepatic portal vein branches, prior splenectomy, or previous unsuccessful attempts. 4. Child-Pugh score ≤12, with anticipated tolerance of the interventional procedure. Exclusion Criteria 1. Thrombosis or severe stenosis of the superior mesenteric vein (SMV), precluding its use as a percutaneous access route. 2. Severe cardiac, pulmonary, or renal insufficiency that precludes tolerance of the procedure. 3. Uncorrectable coagulopathy. 4. Life expectancy \<3 months, or inability to comply with scheduled follow-up visits.

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Conditions

The condition(s) this trial relates to.

esophageal varices with bleeding portal vein thrombosis portal vein, cavernous transformation of

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cavernous transformation of portal vein Gastroesophageal varices bleeding Occlusive portal vein thrombosis (OPVT)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Air Force Medical University

    Xi'an, Shaanxi, 710032, China

More trials for these conditions

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