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Varicose vein study: is it better to treat branch veins now or later?

NCT ID NCT07445425

Symptom relief Sponsor: Sir Run Run Shaw Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at the best way to treat varicose veins in the legs. It compares doing everything in one procedure versus treating the main vein first and the branch veins later. About 206 people will take part, and researchers will track how many need repeat treatment, costs, and symptom relief over six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
radiofrequency ablation with or without foam sclerosing agent therapy
What this could lead to
If it works, this could show that treating branch veins later is just as effective, reducing unnecessary procedures and costs.
What could go wrong
This is an early-stage study with only 206 participants, so results may not apply to everyone. There is also a risk that staged treatment leads to more re-interventions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 206 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: aged between 18 and 80 years; primary unilateral lower limb GSV varicose; hemodynamic classification I and III involvement in tributary veins, tributary veins originating within 15 cm inferior to the knee joint; clinical grade C2-C4; primary trunk diameter of GSV in thigh segment≥3mm to ≤ 15 mm; agree to participate in this study and voluntarily sign an informed consent form. Exclusion Criteria: Body Mass Index (BMI) ≥35kg/m2; severe tortuosity or tight adherence of the trunk of the GSV to the skin in the thigh; history of previous varicose vein surgery on the ipsilateral lower limb (investigator allows to be controlled); previous deep vein thrombosis and/or calf muscle venous thrombosis; uncorrectable coagulation disorders or significant blood abnormalities (platelets≤30×109/L); allergy to lidocaine or sclerosing agents; ankle-brachial index (ABI) \<0.6 and/or absolute ankle pressure \<60mmHg; pregnancy or lactation, or intend to have a child in the next year; participation in other clinical trials; anterior saphenous vein start diameter\>3.5mm; any other patients investigator considers improper to participate in this study.

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Conditions

The condition(s) this trial relates to.

varicose disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Varicose veins of lower limb

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    21 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Affiliated Hospital of Shaoxing University

    Shaoxing, Zhejiang, China

  • Dezhou People's Hospital

    Dezhou, Shandong, China

  • Guangxi Zhuang Autonomous Region People's Hospital

    Nanning, Guangxi, China

  • Hainan Provincial Hospital of Traditional Chinese Medicine

    Haikou, Hainan, China

  • Hangzhou Third People's Hospital

    Hangzhou, Zhejiang, China

  • Huai'an First People's Hospital

    Huai'an, Jiangsu, China

  • Jiangsu Province Hospital of Traditional Chinese Medicine

    Nanjing, Jiangsu, China

  • Peking University International Hospital

    Beijing, Beijing Municipality, China

  • Peking University Third Hospital

    Beijing, Beijing Municipality, China

  • Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310000, China

  • The First Affiliated Hospital of Bengbu Medical University

    Bengbu, Anhui, China

  • The First Affiliated Hospital of China Medical University

    Shenyang, Liaoning, China

  • The First Affiliated Hospital of Dalian Medical University

    Dalian, Liaoning, China

  • The First Affiliated Hospital of Guangxi University of Chinese Medicine

    Nanning, Guangxi, China

  • The First People's Hospital of Chenzhou

    Chenzhou, Hunan, China

  • The Second Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, China

  • The Second Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, China

  • Yantai Yuhuangding Hospital

    Yantai, Shandong, China

  • Zhengzhou Central Hospital

    Zhengzhou, Henan, China

  • Zhoukou Central Hospital

    Zhoukou, Henan, China

  • Zibo First Hospital

    Zibo, Shandong, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.