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Blood tests may replace scopes for kids at risk of bleeding veins

NCT ID NCT07464522

Diagnosis Sponsor: Assiut University Source: ClinicalTrials.gov ↗

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Cancelled before anyone took part.

Expanded access (not trials)

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Approved
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When the status isn't known

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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether non-invasive tests like blood counts and spleen size can accurately predict the presence and severity of enlarged veins in the esophagus (varices) in children with portal hypertension. Researchers will compare these simple markers to the standard method, an endoscopy, in 51 children under 18. The goal is to find a safer, less invasive way to screen for varices and identify those at high risk of bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 51 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Portal hypertension in children will be defined using non-invasive clinical, laboratory, and Doppler-ultrasound criteria, in the context of clinical presentation, without invasive pressure measurements. Patients with portal hypertension will be classified as: patients with hepatic causes and patients with extrahepatic causes All patients included in this study will be subjected to: * 1\. Full Clinical History * 2\. Detailed Clinical Examination * 3\. Laboratory Investigations * 4\. Abdominal Ultrasound * 5\. Doppler Ultrasound * 6.Non-invasive predictive scores for esophageal varices The following parameters will be assessed: * Platelet count (PLT) * Spleen size z-score * Platelet count to spleen size ratio: * CPR (Calculated Platelet Ratio) * APRI (AST to Platelet Ratio Index) * FIB-4 * King score * MELD and PELD scores will be analyzed as secondary variables and not as primary predictors of esophageal varices -7. Esophagogastroduodenoscopy (EGD)

Ages

Up to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged less than 18 years diagnosed with portal hypertension either due to hepatic or extrahepatic causes Exclusion Criteria: * Active variceal bleeding at presentation (hemodynamic instability affects platelet/spleen parameters). * Previous history of variceal bleeding or endoscopic intervention (band ligation/sclerotherapy). * Prior surgical portosystemic shunts or Transjugular Intrahepatic Portosystemic Shunt (TIPS). * Current use of vasoactive drugs for primary prophylaxis (e.g., Non-selective beta-blockers). * Systemic infections or hematological disorders causing independent thrombocytopenia or splenomegaly (to avoid confounding the platelet/spleen ratio).

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Conditions

The condition(s) this trial relates to.

esophageal varices portal hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Esophageal varices Portal hypertension

How to take part

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  1. The official record

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