PORTAL HYPERTENSION

This study is checking how well a device called the Cera Vascular Plug works and if it is safe. It is for people with conditions like aneurysms (bulging blood vessels) or abnormal connections between arteries and veins. The plug is placed into the blood vessel to block blood flow…

This study tests whether adding a blood thinner (apixaban) to a standard heart drug (carvedilol) can prevent serious complications like internal bleeding, fluid buildup, and liver failure in people with cirrhosis and high blood pressure in the liver. About 220 adults with stable …

This study compares two medications, terlipressin and somatostatin, to see which one better lowers high blood pressure in the liver's main vein during a living-donor liver transplant. High pressure there can cause more bleeding during surgery. About 50 adults with severe liver di…

This study is testing a new type of PET/MRI scan to see if it can give a complete picture of the liver in people with cirrhosis. The goal is to measure liver function, blood flow, and detect cancer or high blood pressure in the liver all at once. About 45 adults with cirrhosis wi…

This study tests whether a special ultrasound technique called SHAPE can detect high blood pressure in the liver (portal hypertension) without using a needle. Currently, doctors must insert a catheter into a vein to measure this pressure, which is risky and cannot be done often. …

This study tests if a new, less invasive method using an endoscope (EUS-PPG) can measure liver blood pressure as accurately as the standard method (HVPG). About 40 adults with liver disease will have both measurements during one session. The goal is to see if the newer method can…

This study is creating a large collection of medical data and samples from 1,000 people with portal hypertension, a condition that can cause life-threatening bleeding in the esophagus or stomach. The goal is to use advanced technologies like genetics and imaging to better underst…

This study looks at a procedure called TIPS for people with a rare liver disease (PSVD) that causes high blood pressure in the liver's veins. The goal is to see how well TIPS works compared to using it for cirrhosis patients. Researchers will review medical records from 360 parti…

This study follows 10,000 people with advanced chronic liver disease to see how their condition changes over time. Researchers collect medical data and samples like blood, urine, and tissue to better understand cirrhosis and its complications. The goal is to learn more about the …

This study looks at why some people with liver cirrhosis develop dangerous blood clots in the portal vein (the main vein to the liver). Researchers will take blood samples from both the neck vein and the portal vein during a routine procedure called TIPS. They aim to compare clot…

This study is testing whether a blood test called hepatomiR can predict serious liver problems like fluid buildup, bleeding, or confusion in people with long-term liver disease. Researchers will follow 156 patients to see how well the test works. The goal is to improve future ris…

This study follows 1384 people with high blood pressure in the liver that causes enlarged veins in the esophagus and stomach. Researchers compare those who get endoscopic treatment (using a scope) with those who get other treatments like medicine or surgery. The goal is to see wh…

This study is testing whether a special MRI scan (3D-MRE) can accurately measure pressure in the liver's blood vessels, which is important for managing cirrhosis and advanced liver disease. Currently, doctors must insert a thin tube into a neck vein to measure this pressure, whic…

This study is testing a new, less risky method to measure pressure in the liver's blood vessels using an endoscope with ultrasound. It involves 30 adults with chronic hepatitis and cirrhosis. The goal is to see if this measurement can help predict serious problems like internal b…

This study looks at whether handgrip strength—a simple measure of muscle function—is linked to blood flow changes in the liver's main vein (portal vein) in people with liver cirrhosis. Researchers will measure pressure, speed, and direction of blood flow using different methods (…