PORTAL HYPERTENSION

This study tests a new procedure using an endoscopic ultrasound to guide the injection of materials that block part of the spleen's blood supply. The goal is to lower the risk of life-threatening bleeding from enlarged veins in the stomach and esophagus in people with liver cirrh…

This study looks at two treatments—endoscopy and a procedure called TIPS—to prevent repeat bleeding in people with high blood pressure in the liver (portal hypertension) that causes swollen veins in the stomach or esophagus. Over 1,000 adults who have had a bleeding episode will …

This study tests a new combination of treatments for people with liver cancer that cannot be removed by surgery and who also have high blood pressure in the liver (portal hypertension). The treatment combines a procedure called TACE with three drugs: tislelizumab (immunotherapy),…

This study looks at whether a special ultrasound and a spleen stiffness test can safely measure high blood pressure in the liver (portal hypertension) without a needle. About 107 adults with liver cirrhosis will get both the standard invasive test and the new ultrasound methods. …

This study looks at whether non-invasive tests (like blood counts and spleen size) can accurately predict the presence and severity of esophageal varices in children with portal hypertension. Researchers will compare these markers to the gold-standard endoscopic exam in 51 childr…

This study looks at 2,500 adults with liver scarring (cirrhosis) or high blood pressure in the liver (portal hypertension) to find out how often bleeding happens during planned medical procedures. Current blood tests don't predict bleeding well, so researchers will track patients…

This study tests a new fiber-optic navigation system during a procedure called TIPS, which treats complications of liver cirrhosis like fluid buildup or bleeding. About 30 adults needing this procedure will be enrolled. The goal is to see if the technology helps doctors complete …