PORTAL HYPERTENSION

This study tests whether adding the blood thinner apixaban to the heart drug carvedilol can prevent complications like bleeding, fluid buildup, and confusion in people with cirrhosis and high blood pressure in the liver. About 220 adults with stable cirrhosis will take either api…

This study compares an early shunt procedure (TIPS) against standard care (diuretics and fluid drainage) in 134 adults with liver cirrhosis who have developed ascites (fluid buildup in the belly) for the first time. The goal is to see if TIPS improves survival without needing a l…

This study tests two drugs, terlipressin and somatostatin, to see which one better lowers high blood pressure in the liver's main vein during a living-donor liver transplant. High pressure can cause dangerous bleeding, so finding the best drug may improve safety. About 50 adults …

This study is checking how well a device called the Cera Vascular Plug works and if it is safe. The plug is used to block blood flow in certain blood vessels to treat conditions like aneurysms, abnormal connections between arteries and veins, and other problems. About 132 adults …

This study is testing whether a special MRI scan called 3D-MRE can accurately detect high blood pressure in the liver (portal hypertension) caused by cirrhosis or advanced liver disease. Currently, doctors use an invasive catheter procedure (HVPG) to measure this pressure. The st…

This study tests whether a special ultrasound technique (SHAPE) can detect high blood pressure in the liver without using a needle. Portal hypertension is a serious condition that can lead to severe liver damage and death. The standard test requires inserting a catheter into a ve…

This study aims to improve how doctors see liver damage (cirrhosis), liver cancer, and high blood pressure in the liver using a special PET/MRI scan. About 45 adults with cirrhosis will get this scan to see if it gives clearer pictures than current methods. The goal is to make di…

This study compares two methods for measuring blood pressure in the liver (portal hypertension) in people with cirrhosis or other liver conditions. The standard method (HVPG) uses a catheter inserted through a neck vein, while the newer method (EUS-PPG) uses an endoscope passed t…

This study follows 10,000 people with advanced chronic liver disease at Vienna General Hospital. Researchers will track their health over time, collect blood, urine, and tissue samples, and record complications like bleeding or liver failure. The goal is to better understand how …

This study follows 2000 people with severe liver-related high blood pressure who receive a TIPS procedure, which creates a bypass in the liver. Researchers will track survival, need for liver transplant, and complications like confusion or liver failure over 12 months. The goal i…

This study follows 500 adults in Austria with primary biliary cholangitis, a chronic liver disease. Researchers will collect medical data and optional blood or tissue samples to track how the disease progresses, what complications arise, and how symptoms affect patients. The goal…

This study looks at people with high blood pressure in the liver that causes swollen veins in the esophagus and stomach. Researchers will compare those who get an endoscopic procedure (using a camera down the throat) with those who receive other treatments like medicine or surger…

This study looks at whether handgrip strength—a simple measure of muscle function—can help predict changes in blood flow through the liver's main vein in people with cirrhosis. Researchers will measure blood pressure and flow in the portal vein and nearby veins before and after a…

This study is creating a large collection of medical data and biological samples from 1000 people with portal hypertension, a condition that can cause dangerous bleeding in the esophagus or stomach. The goal is to use advanced technologies like genetics and imaging to better unde…

This study tests a new, safer method to measure pressure in the liver's blood vessels using an endoscope with ultrasound. It involves 30 adults with chronic hepatitis-related cirrhosis. The goal is to see if this technique can help predict serious complications like internal blee…

This study looks at why some people with liver cirrhosis develop blood clots in the portal vein (a major liver blood vessel). Researchers will compare blood samples taken from a neck vein and the portal vein during a routine procedure (TIPS) in 45 adults. The goal is to understan…

This study is testing a blood test called hepatomiR to see if it can predict when people with long-term liver disease will have serious complications like fluid buildup in the belly, bleeding in the stomach, or confusion. The goal is to better understand what causes these events …

This study looks at how well a procedure called TIPS works for people with a rare liver disease called Porto-Sinusoidal Vascular Disease (PSVD) that causes high blood pressure in the liver. Researchers will compare 360 patients who had TIPS for PSVD with similar patients who had …