PORTAL HYPERTENSION

This study looks at two treatments—endoscopy and a procedure called TIPS—to prevent repeat bleeding from enlarged veins in the stomach or esophagus caused by liver disease. Over 1,000 adults with this condition will be followed for a year to see which approach works better. The g…

This study tests a new procedure using an endoscopic ultrasound to guide the injection of tiny particles into the spleen, reducing blood flow and lowering the risk of dangerous bleeding in people with liver cirrhosis. The goal is to see if this method is safer and more effective …

This study tests a new way to use a stent (a small tube) in the liver to lower blood pressure and prevent dangerous bleeding in people with cirrhosis. The new method uses a smaller balloon to open the stent, which may reduce side effects. 240 adults who have recovered from a firs…

This study tests a new combination of four treatments for people with liver cancer that cannot be removed by surgery and who also have high blood pressure in the liver (portal hypertension). The goal is to see if adding a blood-pressure drug (carvedilol) to standard cancer therap…

This study tests whether a combination of contrast-enhanced ultrasound and spleen stiffness measurement can accurately detect high blood pressure in the liver (portal hypertension) in people with cirrhosis. Currently, doctors must insert a catheter into a neck vein to measure thi…

This study looks at whether non-invasive tests like blood counts and spleen size can accurately predict the presence and severity of enlarged veins in the esophagus (varices) in children with portal hypertension. Researchers will compare these simple markers to the standard metho…

This study looks at whether a special 4D MRI scan can accurately measure blood flow and pressure in the liver without needing an invasive needle procedure. It will enroll 60 adults with cirrhosis, some with early-stage disease and others needing a shunt (TIPS) for complications. …

This study looks at 30 people with liver cirrhosis who need surgery to remove the spleen and disconnect certain blood vessels to treat bleeding. Researchers want to see if this surgery helps or harms kidney function over two years. Participants will have regular blood and urine t…

This study tests a fiber-optic navigation system that gives doctors a 3D view during a procedure called TIPS, used to treat complications of liver cirrhosis like fluid buildup or bleeding. About 30 adults needing this procedure will take part. The goal is to see if the new tool r…

This study follows 30 people with liver cirrhosis who need spleen surgery to treat bleeding from high blood pressure in the liver. Researchers will check their cholesterol and fat levels before and for two years after surgery. The goal is to see if the surgery improves abnormal f…

This study will follow 2,500 patients with liver cirrhosis or portal hypertension who are scheduled for elective medical procedures. Researchers want to find out how often bleeding happens and what factors predict it, beyond standard blood tests. The goal is to improve safety by …

This study looks at whether a simple, non-invasive ultrasound can predict the risk of dangerous bleeding from enlarged veins in the esophagus (varices) in people with liver cirrhosis. Researchers will measure spleen size and a key blood vessel diameter on ultrasound and compare t…