Respiratory failure

Researchers compare the Trilogy ventilator, a portable breathing machine, with conventional mechanical ventilators in people who need breathing support. Participants use each device for one hour while set to their usual breathing mode and prescription settings. The study measures…

Researchers are testing whether a higher dose of dexamethasone works better than a lower dose for adults on ventilators with acute hypoxemic respiratory failure caused by infections, including COVID-19. The trial enrolls 980 patients in Spanish intensive care units and randomly a…

Researchers are testing whether an automated oxygen delivery system called O2matic keeps blood oxygen levels in a safe range better than manual adjustment for patients hospitalized with a COPD flare-up. The device continuously measures oxygen saturation and uses an algorithm to c…

This study asks whether critically ill adults on ventilators do better if doctors reduce breathing support early, within a day after a 48-hour stability checkpoint, or if they keep support at the same level for longer. Researchers will compare two strategies: early de-escalation,…

This trial tests whether ECMO, a machine that temporarily takes over heart and lung function, can safely help adults with respiratory failure who are not improving with standard care. Researchers will enroll 30 patients with high carbon dioxide levels and low blood pH, including …

This trial tests whether high-flow nasal oxygenation (HFNO) keeps breathing and oxygen levels steadier than standard low-flow nasal oxygenation (LFNO) in patients undergoing sedated vitrectomy, a type of eye surgery. Participants are normal-weight adults with different anesthesia…

This trial compares two types of breathing support given right after a breathing tube is removed in patients over 50 with type II respiratory failure who had difficulty weaning from a ventilator. One method delivers warm, moist oxygen through small nasal prongs, while the other u…

This trial tests whether continuous pulse oximetry with wireless alerts to clinicians can reduce serious breathing complications (respiratory depression) after surgery. Patients on two surgical wards will be monitored continuously instead of every four hours. The goal is to see i…

This trial compares two modes of noninvasive ventilation in adults with acute respiratory failure: standard pressure support (PSV) and a newer mode called Neurally Adjusted Ventilatory Assist (NAVA). NAVA uses electrical signals from the diaphragm to trigger breathing support, wh…

This study tests whether adding visual and sound reminders to a standard breathing exercise device (incentive spirometer) helps patients use it more often after surgery. About 231 adults who had surgery under general anesthesia will be split into two groups: one using the device …

This study tested whether early hemofiltration, a continuous dialysis procedure, could improve survival in children who develop respiratory failure after a bone marrow transplant. Only 6 children took part. The idea was to filter out inflammatory molecules that drive lung damage.…

This study looked at whether using a noninvasive ventilation mask (NIV) can help patients with chronic respiratory failure wean off mechanical ventilation more successfully. 205 patients who had been on a breathing tube for at least 48 hours and failed a spontaneous breathing tes…

This study tested two ways of managing breathing during heart bypass surgery to see which better prevents lung complications. Over 1,500 adults having planned heart surgery were randomly assigned to either no breathing support or gentle, low-volume breaths while on the heart-lung…

This study tested whether giving high-flow heated oxygen through nasal prongs helps more people survive severe breathing failure than standard oxygen masks. Over 1,500 adults with low blood oxygen levels were randomly assigned to one of the two oxygen methods. The main goal was t…

This study tested whether high-flow nasal oxygen therapy works as well as standard noninvasive ventilation for people with a moderate COPD flare-up. Fifty-one patients were randomly assigned to one of the two treatments for the first 24 hours. The main goal was to see how each me…

This study tested whether it is possible to set personalized blood pressure targets for critically ill patients using a brain oxygen monitor. Sixteen ICU patients on breathing machines or shock medications had their blood pressure adjusted to match individual brain blood flow nee…

This study looked at whether a medicine called milrinone can improve oxygen levels in newborns with congenital diaphragmatic hernia (CDH), a birth defect that causes severe breathing problems. The trial included 66 babies who were on breathing machines. The goal was to see if mil…

This study looked at whether giving nebulised heparin (a blood thinner delivered as a mist) to COVID-19 patients on mechanical ventilation could help them get off the breathing machine sooner and reduce deaths. The trial combined data from several smaller studies in Australia, Ir…

This study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …

This study tests a new method to measure lung blood flow using electrical impedance tomography (EIT) without requiring patients to hold their breath. Twenty-four adults on respiratory support will receive a salt-water injection and have their lungs scanned during normal breathing…

This study tested a new scoring system called ExPreS to help doctors decide when patients on breathing machines (ventilators) are ready to have the tube removed. Over 500 adults in intensive care units were randomly assigned to use ExPreS or standard care. The goal was to see if …

This study tested whether giving breathing support early (non-invasive ventilation and high-flow nasal oxygen) to people with chest injuries and low oxygen levels could prevent them from needing a breathing tube. 144 patients in the ICU took part. The goal was to see if this earl…

Researchers are testing whether adjusting a patient's body position based on where the lung infection sits, combined with mechanical vibration on the chest, helps clear infected mucus better than routine position changes. The trial enrolls 384 adults in intensive care who need a …

This study tests whether using a mechanical insufflation device (BiWaze Cough) twice daily for 6 months can slow the decline in cough strength in 20 people with early ALS. Participants will use a facemask or mouthpiece to help inflate their lungs fully before coughing. Researcher…

This trial tests whether adding breathing exercises to standard physiotherapy improves lung function, pain, and quality of life in people with thoracic discopathy, a condition affecting the upper spine. Forty participants will be randomly assigned to receive either 15 sessions of…

This trial tests whether ciprofol, a newer sedative, provides better and safer sedation than the standard drug propofol for people undergoing bronchoscopy, a procedure to examine the airways. Both are given with a low dose of sufentanil for pain relief. The study involves 100 adu…

After surgery, painkillers can slow breathing. This study tested a device that uses a mild electrical pulse on the skin to wake patients when their breathing stops for 10 seconds. Researchers enrolled 60 adults recovering from surgery to see if the system is practical and accepta…

This study compared two breathing devices—CPAP and bilevel ventilation—in people with severe fluid buildup in the lungs (pulmonary edema). The goal was to see which device improves breathing faster. Participants were adults in respiratory distress. The results could help doctors …

This study looked at 100 adults with COPD who needed a breathing tube and a ventilator. It compared two approaches: giving sedation with daily breaks versus giving no sedation at all. The goal was to see which method leads to more days off the ventilator and fewer complications i…

This study tested whether a newer breathing machine method (NAVA) helps patients with respiratory failure come off the ventilator faster than the usual method (PSV). The study included 47 adults who had trouble weaning from the ventilator. Researchers measured how long it took to…

This study tested whether a high-flow oxygen system (Optiflow) works better than a standard oxygen mask for patients with breathing failure. About 100 adults in intensive care who needed non-invasive ventilation (NIV) took part. The goal was to see if Optiflow keeps oxygen levels…

This study tested whether giving propofol sedation during a lung exam (bronchoscopy) under noninvasive ventilation helps patients with severe breathing failure stay more comfortable and maintain oxygen levels. Forty-six adults with acute respiratory failure needing a diagnostic l…

This study compared two sedatives, dexmedetomidine and propofol, in 100 high-risk patients undergoing ERCP. The goal was to see which drug causes fewer breathing and heart problems. Researchers monitored vital signs closely to find the safer option for these vulnerable patients.

This study looked at whether lying face down (prone positioning) helps hospitalized COVID-19 patients who have low oxygen levels but are not candidates for breathing machines. About 596 adults took part. The goal was to see if this simple position change could lower the chance of…

This study tested a team-based approach to managing sedation in children with acute respiratory failure who need a breathing machine. The goal was to reduce the number of days on the ventilator. Over 2,400 children from multiple hospitals participated, comparing the team approach…

This study tested whether taking L-arginine and liposomal vitamin C supplements twice daily could reduce fatigue in people with COPD and chronic respiratory failure. 101 patients were randomly assigned to receive the supplements or a placebo during a 28-day pulmonary rehabilitati…

This study tested a new automatic setting (Auto-EPAP) on a ventilator to see if it could better manage airway blockages during sleep compared to the standard manual setting. It involved 23 adults with conditions like sleep apnea, COPD, or obesity-related breathing problems who al…

This study looked at 102 children who had surgery for a heart problem present at birth. After surgery, they were placed on their stomachs with their heads raised at different angles (10°, 30°, or 45°) to see which angle best helped their heart and lungs recover. The goal was to f…

This study looked at whether giving the drug salbutamol (often used in asthma inhalers) through a nebulizer helps people with severe COPD who are having a flare-up and need a breathing machine. The trial included 43 adults and compared the drug to a placebo. The main goal was to …

This study tested whether a computer-driven system called Smartcare/PS could help children with respiratory failure come off a breathing machine faster than usual care. Thirty children were enrolled, and the system automatically adjusted breathing support based on each child's ne…

This study tested a 6-week coaching program based on the Information-Motivation-Behavioral skills model to help patients with chronic hypercapnic respiratory failure use their home ventilator more consistently. The program included education, motivation, and practical skills trai…

This study tested a modified high-flow oxygen device in 160 adults with acute respiratory failure who needed a bronchoscopy (a tube inserted into the lungs to diagnose or treat disease). The device delivers oxygen through one nostril while the procedure uses the other. The goal w…

This study tested whether adding a second nerve block (rectus sheath block) to a standard chest wall block (pectointercostal fascial plane block) improves pain control after heart surgery. 62 adults having elective heart surgery through a breastbone incision were randomly assigne…

This study tested whether a remote monitoring bundle—including a carbon dioxide monitor, tablet, weight scale, and health app—could help doctors and families make better decisions about ventilator support for children at home. Fifty children aged 0 to 17 who use a breathing machi…

This study looked at 108 adults with COVID-19 pneumonia who had low oxygen levels (type 1 respiratory failure). Researchers compared two breathing support methods: High-Velocity Nasal Insufflation (HVNI) and Continuous Positive Airway Pressure (CPAP). The goal was to see which on…

This study tested whether critically ill patients on breathing machines could safely manage their own sedation using a button-controlled device. 161 adults in the ICU were randomly assigned to either self-manage their sedation or have it managed by a nurse. The goal was to see if…

This pilot study tested whether a therapy that combines behavioral activation for depression with physical rehabilitation is feasible for survivors of acute respiratory failure. Fifty-two adults who had been on life support in the ICU received home visits and phone calls from the…

This study tested whether a family-centered care approach—where parents are trained and actively involved—improves vital signs and shortens recovery time in infants (28 days to 2 years) with lower respiratory tract infections who need high-flow nasal oxygen. Sixty infants partici…

This early-stage study tests a new drug called ENA-001 in 36 healthy adults to see if it is safe and how the body processes it. Participants receive a single dose either through a vein or as a shot. The goal is to gather safety information before testing it in patients with respi…

Researchers at Erasmus Medical Center are studying whether switching patients with acute hypoxemic respiratory failure from controlled to assisted mechanical ventilation earlier than usual changes the stress on different parts of the lungs. The study enrolls 20 adults on a breath…

This study asks whether a portable external power supply can keep respiratory support equipment running without interruption during ambulance transport. Researchers survey healthcare workers worldwide about current transport practices and then test the power device during 25 ambu…

This trial tests a new monitoring device, the Linshorn CPRM, which fits into an oxygen mask and tracks breathing and oxygen levels every second. Researchers will compare its predictions with standard monitoring in 320 adults recovering from non-cardiac surgery in the post-anesthe…

This study watches how a high-frequency ventilator (Servo-n HFOV) works in real hospital use for babies with severe breathing failure. About 75 infants will be observed to see if the machine safely helps them get enough oxygen and remove carbon dioxide. The goal is to gather info…

This study looked at 77 ICU patients on breathing machines who needed a tracheostomy. Doctors used either a camera (bronchoscopy) or ultrasound to guide the procedure. The goal was to see which method caused fewer changes in breathing and blood gas levels. The results could help …

This study examines how children under 18 with cancer or a history of a stem cell transplant do when they need a machine called ECMO to help them breathe. Researchers looked at bleeding, infections, and survival rates in children treated at one hospital, and compared survival wit…

This study tests whether machine learning can predict death in the intensive care unit for patients with acute hypoxemic respiratory failure (AHRF), a common cause of ICU admission. Researchers will analyze data from over 1,200 patients, using several machine learning algorithms …

This study tests whether machine learning can predict if a patient with acute hypoxemic respiratory failure will need a breathing machine for a week or longer. Researchers analyzed data from over 1,200 ICU patients in Spain, using information from the first 48 hours to build a pr…

This study looks at how breathing machines (mechanical ventilators) might injure the diaphragm, the main muscle used for breathing. Researchers will monitor 50 ICU patients over their first 7 days on the ventilator, measuring diaphragm activity and function. The goal is to unders…

This study observed over 1,600 adults in French emergency rooms to understand how patients are managed in the resuscitation area and whether being admitted directly to that area versus later affects their need for intensive care within 24 hours. Researchers recorded patient detai…

This study tests an artificial intelligence program designed to predict the best time to remove a breathing tube (extubation) from patients in intensive care. Researchers will use data from 1500 adults who were on a ventilator for at least 72 hours across four hospitals. The AI a…

This study tested a new sensor placed inside the nose to measure carbon dioxide levels in 21 people with breathing conditions like COPD or obesity-related breathing problems. The goal was to see if the sensor is safe, easy to use, and gives accurate readings compared to standard …

This study looked at two breathing treatments—high-flow oxygen and non-invasive ventilation—in 16 adults with sudden breathing failure from pneumonia. The goal was to see which one better opens up the lungs. The results showed no major difference in lung opening, though non-invas…

This pilot study tested a new algorithm that estimates how hard patients are working to breathe while on high-flow nasal oxygen. Researchers enrolled 20 ICU patients and used a noninvasive sensor to collect pressure and flow data. The goal was to see if the algorithm could reliab…

This study looked at how a low dose of ketamine, a medicine often used for anesthesia, affects breathing and brain activity in 15 critically ill patients who were on breathing machines (ventilators) in the ICU. The goal was to see if ketamine could help stimulate breathing and im…

This study looked at 50 ICU patients with acute respiratory failure to see if a heart ultrasound test (measuring how the main vein collapses) could predict who would die or need a breathing tube. The goal is to help doctors give fluids more safely. It was an observational study, …

This completed study tested whether an AI system could improve how ventilators are set for children (ages 1 month to 18 years) in the pediatric ICU with breathing problems like pneumonia or respiratory failure. Researchers compared AI-generated recommendations to the actual adjus…

This study looked at whether using a checklist before placing a breathing tube in intensive care unit (ICU) patients reduces complications. Researchers reviewed records of 60 critically ill adults who needed a breathing tube, comparing those treated before and after the checklist…

This study looked at the experiences of 126 people in Denmark who rely on a breathing machine at home, along with their families and the trained caregivers who help them. The goal was to understand the challenges and successes of this life-sustaining care. No new treatments were …

This study looked at whether lying face down (prone position) while awake can improve how air moves through the lungs in COVID-19 patients with breathing failure. Twenty adults with COVID-19 and low oxygen levels were monitored using a special imaging technique (EIT) to measure l…

This study looked at how well CPAP therapy works for COVID-19 patients who have trouble breathing. Researchers collected data from 250 patients in a hospital to see how they responded to treatment. The goal was to learn more about managing severe COVID-19 in real-life settings.

This study tested whether using a contrast dye during 3D ultrasound can accurately measure the size and function of the right heart chamber in people who had surgery for congenital heart disease. 25 participants received an injection of Lumason (an ultrasound contrast agent) and …

This study tested whether an asymmetrical high-flow nasal cannula reduces the work of breathing compared to a conventional one in 40 patients with acute respiratory failure. Participants received both devices at different flow rates, and researchers measured diaphragm and chest m…

This study looked at 28 ICU patients on breathing machines to see if a diaphragm ultrasound could catch a specific breathing problem called double triggering. Researchers compared the ultrasound results to standard ventilator readings. The goal is to find a better way to monitor …

This study tested whether giving high-flow oxygen through the nose just before removing a breathing tube is safe and acceptable for patients in intensive care with severe breathing problems. Only 2 patients took part, and the main goal was to see if a larger study is possible. Th…

This study looked at whether a blood test measuring suPAR levels can predict which adults hospitalized with COVID-19 will develop severe breathing failure requiring a breathing tube. Researchers analyzed stored blood samples from about 367 patients. The goal was to see if a suPAR…

This study tested whether using a monitor that tracks breathing and oxygen levels (called IPI) can prevent dangerous oxygen drops during ERCP, a procedure to examine the bile ducts. 80 adults having elective ERCP under moderate sedation were randomly assigned to either standard m…

This pilot study tested three common ventilator modes—volume control, pressure control, and adaptive pressure control—in 566 ICU adults with respiratory failure. The goal was to see which mode leads to more days alive and off the ventilator. The study is a first step to guide fut…

This University of Oxford study looked at 48 ICU patients on ventilators for respiratory failure. Doctors sometimes inflate the lungs briefly (a recruitment manoeuvre) to reopen collapsed areas, but it's unclear when this helps. Researchers used a device to measure lung volume an…

This study looked at how the COVID-19 lockdown changed the health habits and medical care of 1,343 people with chronic conditions like heart disease, multiple sclerosis, and hemophilia. Researchers used phone surveys to track medication use, lifestyle changes, and access to healt…

This study tested a virtual support program for 444 people starting home ventilation. The program used online tools to help patients and caregivers manage care at home. Researchers measured if it reduced emergency room visits and eased caregiver stress compared to usual care.

This study looked at 600 COVID-19 patients with severe breathing problems who were treated with high-flow nasal oxygen and asked to lie face-down (awake prone position). The goal was to see if this combination reduced the need for a breathing tube and lowered death rates. Researc…

This study looked at how different settings on a kidney support machine (CRRT) affect the ability of a lung support machine (ECCO2R) to remove carbon dioxide from the blood of 10 adults with respiratory failure. Researchers tested two methods to see which one helps the lung machi…

This study looked at whether measuring tiny brain signals during a breathing test can help predict if a patient on a ventilator will successfully breathe on their own. Researchers monitored 70 intubated adults as they tried breathing without the machine. The goal is to find a sim…

This study examined the immune systems of 120 COVID-19 patients who had trouble breathing. Researchers measured many immune markers in the blood to see if an overactive immune response causes lung damage. They also compared these markers to healthy people and looked for patterns …

This study tested a nurse-led weaning protocol for high-flow nasal cannula (HFNC) oxygen therapy in 150 infants aged 1-24 months hospitalized with bronchiolitis. The goal was to see if a structured weaning plan could reduce the time on HFNC, shorten hospital stays, and lower cost…

This study looked at 212 critically ill adults in one ICU to see if three blood test ratios could predict death. The ratios compare lactate, CRP, and procalcitonin to albumin levels. Researchers will check if these ratios are linked to survival and find cut-off values to help doc…

This study compared two methods—automatic tube compensation (ATC) and pressure support ventilation (PSV)—for helping adults with respiratory failure come off a breathing machine. Fifty patients were monitored during short breathing trials to see which method improved oxygen excha…

This study tested a wearable, wireless device that listens to breathing to detect when opioids cause dangerously slow or shallow breathing. Researchers enrolled 14 healthy volunteers to see how well the device works in noisy environments. The goal was to compare accuracy with and…

This study looked at whether a helmet or a facemask is better at helping people with acute low-oxygen respiratory failure breathe easier. Twenty adults each tried both devices in a random order, and researchers measured how hard their breathing muscles worked and how well their l…

This study looked at 24 critically ill patients on breathing machines to see how changing the machine's settings affects measurements of breathing effort. Researchers compared a simple bedside measurement with a more invasive gold-standard technique. The goal was to find the best…

This study tested a new device called FRNDS, a nasal cannula that can measure how much air a person breathes while also delivering air. Researchers compared it to standard chest belts in 57 healthy adults. The goal was to see if the cannula works as well as current methods, which…

This study followed 60 people who survived a severe breathing crisis in the ICU. Researchers wanted to learn about their health, sleep disorders, and why some need to return to the hospital. Participants had sleep tests three months after leaving the ICU and were tracked for a ye…

This study looked at whether lung ultrasound can predict if elderly patients (65+) will need breathing support again after their breathing tube is removed following surgery. Researchers followed 130 patients and checked ultrasound scores, diaphragm movement, and oxygen levels. Th…