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New nasal cannula design may ease breathing in respiratory failure

NCT ID NCT06204276

Knowledge-focused Sponsor: Siriraj Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether an asymmetrical high-flow nasal cannula reduces the work of breathing compared to a conventional one in 40 patients with acute respiratory failure. Participants received both devices at different flow rates, and researchers measured diaphragm and chest muscle activity using ultrasound. The goal was to see if the new design improves breathing patterns and gas exchange.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Asymmetrical high-flow nasal cannula (device)
What this could lead to
If it works, this could point toward a more effective way to support breathing in patients with acute respiratory failure.
What could go wrong
This is a small, early-stage study (40 participants) that only measures short-term effects, so results may not apply to all patients or lead to a clear benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jan 2024

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Patients with acute hypoxemia respiratory failure Inclusion Criteria: * Age \> 18 years old * Acute respiratory failure within 7 days of hospital admission? * Hypoxemia defined by arterial partial pressure of oxygen (PaO2)/FiO2 \< 300 mmHg or SpO2/FiO2 \< 315 * Already supported with HFNC device Exclusion Criteria: * Respiratory acidosis: pH \< 7.30 and PaCO2 \> 45 mmHg * Hemodynamic instability requiring vasopressor initiation * Diminished level of consciousness or uncooperative * Active hemoptysis or pneumothorax requiring a chest tube * Chronic severe neuromuscular disease * Pregnancy Patients with acute hypercapnic COPD Inclusion criteria * Age \> 40 years old * Diagnosed COPD according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline (postbronchodilator forced expiratory volume at 1 second (FEV1)/forced vital capacity (FVC) \< 70%) * Exacerbation requiring hospitalization; at least 2 of the following criteria 1. Respiratory rate \> 24/min 2. Use of respiratory accessory muscles or paradoxical motion of the abdomen 3. Acute respiratory acidosis with arterial or venous pH \< 7.35 and/or PaCO2 \> 45 mmHg Exclusion criteria * pH \< 7.25 * Hemodynamic instability requiring vasopressor initiation * Persistent hypoxemia despite supplemental oxygen therapy * Diminished level of consciousness or uncooperative * Active hemoptysis or pneumothorax requiring a chest tube * Associated severe chronic neuromuscular disease * Pregnancy

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Conditions

The condition(s) this trial relates to.

acute respiratory failure respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute hypercapnic respiratory failure Acute hypoxemic respiratory failure

Contacts and locations

Locations

  • Faculty of Medicine Siriraj Hospital

    Bangkok Noi, Bangkok, 10700, Thailand

More trials for these conditions

Other studies related to the condition(s) this trial covers.