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Which ventilator setting helps patients breathe easier? small study compares two methods

NCT ID NCT07238140

Knowledge-focused Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two methods—automatic tube compensation (ATC) and pressure support ventilation (PSV)—for helping adults with respiratory failure come off a breathing machine. Fifty patients were monitored during short breathing trials to see which method improved oxygen exchange and breathing patterns. The goal was to find which technique better predicts successful removal of the breathing tube.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If one method proves better, it could help doctors choose the most effective way to wean patients off ventilators, potentially reducing time on breathing machines.
What could go wrong
This is a small, completed study with only 50 participants, so results may not apply to all patients. The findings compare two existing techniques rather than testing a new breakthrough.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

May 2019

Finished

Mar 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years. * Admitted with acute respiratory failure (ARF). * On mechanical ventilation with Puritan-Bennett 840 ventilator for ≥24 hours. * Considered for weaning after improvement or resolution of underlying cause. * Fully conscious. * Minimal or no requirement for vasoactive drugs or sedation. * Adequate gas exchange (PaO₂/FiO₂ \>200 at PEEP 5 cmH₂O and FiO₂ \<0.5) Rapid shallow breathing index (RSBI) \<105 breaths/min/L. Exclusion Criteria: * Age \<18 years. * Pre-existing chronic obstructive pulmonary disease (COPD). * Neuromuscular disorders. * Hemodynamic instability requiring high-dose vasoactive support. * Persistent altered level of consciousness. * Ongoing sedation. * Severe metabolic or electrolyte disturbances. * Morbid obesity (BMI ≥40 kg/m²). * Tracheostomy. * Pregnancy. * Refusal to participate by patient or legal guardian.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute hypoxemic respiratory failure

Contacts and locations

Locations

  • intensive care unit Department, Ain Shams University Hospital

    Cairo, Cairo Governorate, 11835, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.