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Oxford researchers seek better way to open collapsed lungs in ICU

NCT ID NCT05508724

Knowledge-focused Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This University of Oxford study looked at 48 ICU patients on ventilators for respiratory failure. Doctors sometimes inflate the lungs briefly (a recruitment manoeuvre) to reopen collapsed areas, but it's unclear when this helps. Researchers used a device to measure lung volume and see if pressure-volume curves can predict which patients benefit. The goal is to improve decision-making for this common ICU procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors better decide when to perform recruitment manoeuvres in ventilated patients, potentially improving lung function.
What could go wrong
This is a small, observational study (48 participants) that aims to understand a measurement technique, not to test a new treatment. Results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

48 people

The number who actually took part.

Started

Oct 2022

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be recruited from Intensive Care Units at the Royal Berkshire Hospital in Reading, England. The study population is constituted of patients receiving mechanical ventilation on ICU due to respiratory failure.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and female, aged 18 years or above * Receiving mechanical ventilation for respiratory failure via an endotracheal tube on ICU Exclusion Criteria: * Consultee indicates patient would be likely to decline enrolment * Patient is receiving palliative care * Language barriers prevent sufficiently good communication with patient or consultee for full consent to be obtained

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome respiratory distress syndrome in premature infants respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Respiratory distress syndrome Respiratory failure Respiratory insufficiency Shock lung

Contacts and locations

Locations

  • Royal Berkshire Hospital, Royal Berkshire Foundation Trust

    Reading, RG1 5AN, United Kingdom

More trials for these conditions

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