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New scoring tool could predict when ventilator patients can breathe on their own

NCT ID NCT05085457

Diagnosis Sponsor: Universidade do Oeste de Santa Catarina Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new scoring system called ExPreS to help doctors decide when patients on breathing machines (ventilators) are ready to have the tube removed. Over 500 adults in intensive care units were randomly assigned to use ExPreS or standard care. The goal was to see if ExPreS could improve the number of successful extubations and reduce the need to put the tube back in.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ExPreS diagnostic scoring protocol
What this could lead to
If successful, this scoring tool could help doctors more accurately decide when to remove a breathing tube, reducing complications and time in the ICU.
What could go wrong
This is a completed trial, but the score may not work for all patient types or in all hospitals. The study is relatively small and results may not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

540 people

The number who actually took part.

Started

Nov 2021

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pacients admitted in ICU that are more than 18 years; * MV for more than 24 hours; * Assignature of the free and informed consent form by a family member or responsable adult. Exclusion Criteria: * Death before SBT; * Tracheostomy; * Self-extubation; * Accidental extubation; * Absence of signature of informed consent.

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Conditions

The condition(s) this trial relates to.

respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Respiratory insufficiency

Contacts and locations

Locations

  • Hospital Universitário Santa Terezinha

    Joaçaba, Santa Catarina, 89600-000, Brazil

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