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Can a dialysis-like treatment save kids with lung failure after transplant?

NCT ID NCT00120575

Disease control Sponsor: Stanford University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether early hemofiltration, a continuous dialysis procedure, could improve survival in children who develop respiratory failure after a bone marrow transplant. Only 6 children took part. The idea was to filter out inflammatory molecules that drive lung damage. The trial is complete, but results are limited due to the very small number of participants.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hemofiltration (a continuous form of dialysis)
What this could lead to
If it works, this could point toward a way to reduce deadly inflammation and improve survival in children with respiratory failure after bone marrow transplant.
What could go wrong
This was a very small, early-phase trial with only 6 participants, so results may not apply broadly. Hemofiltration carries risks like infection or bleeding, and the treatment may not change outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

6 people

The number who actually took part.

Start date

Jan 2005

Finished

Feb 2009

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

1 month to 21 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * hematopoietic stem cell recipient * respiratory failure fulfilling ARDS criteria * mechanical ventilation (invasive / non-invasive) Exclusion Criteria: * extracorporeal membrane oxygenation (ECMO) * predominance of congestive heart failure * code status: a patient must be willing to accept invasive mechanical ventilation if clinically indicated

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bone marrow transplantation Respiratory insufficiency

Contacts and locations

Locations

  • Children's Healthcare of Atlanta @ Egleston

    Atlanta, Georgia, 30322, United States

  • Children's Hospital and Research Center

    Oakland, California, 94609, United States

  • Children's Hospital of British Columbia

    Vancouver, British Columbia, Canada

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Duke University

    Durham, North Carolina, 27710, United States

  • Great Ormond Street Hospital

    London, United Kingdom

  • University of Ulm

    Ulm, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.