Periapical periodontitis

This study compared three approaches for treating dead, infected adult teeth: a regenerative procedure that induces bleeding inside the tooth, standard cleaning and sealing, and a combination. Fifty-four adults with an infected upper premolar were treated and followed for healing…

This trial tests whether two newer root canal cleaning devices—GentleWave and Waterlase—can improve healing compared to the standard ultrasonic method. About 120 people needing a root canal will be randomly assigned to one of the three techniques. The study tracks how well the in…

This trial compares three treatments for mature teeth with apical periodontitis (infection at the root tip): standard root canal treatment, regenerative endodontic treatment using a blood clot, and regenerative treatment with added bone-growth proteins. The study includes 30 heal…

This study compares two materials used to seal the tip of a tooth root during surgery for persistent infections after root canal treatment. About 110 adults will receive either MTA or TotalFill BC-RRM Fast Set Putty. Researchers will check healing with 3D X-rays after one year to…

This trial looks at whether antibiotics are needed after removing a tooth with a periapical abscess (an infection at the root tip). Half of the 176 adult participants receive amoxicillin for 5 days after extraction, while the other half get only pain relievers. A dentist checks t…

This study tested whether adding photodynamic therapy (a light-activated treatment) to standard sodium hypochlorite irrigation better kills bacteria in root canals. 64 adults needing root canal treatment were randomly assigned to receive either sodium hypochlorite alone or with p…

This study tested two different materials used in root canal treatment for teeth with both root and gum infections. 120 adults received either a mineral-based plug (MTA) or a standard resin sealer. Researchers measured healing and inflammation markers after one year to see which …

This study tested a new, less invasive way to treat infected baby molars in children aged 4 to 10. Instead of fully cleaning out the tooth canals (standard pulpectomy), the new method uses an antibiotic paste to kill infection without drilling. The study involved 110 children and…

This study looked at whether making a larger opening at the tip of the tooth root helps regenerative dental treatment work better for adults with infected mature teeth. 36 people received one of two treatment sizes and were followed for healing and pain. The goal was to see which…

This study looked at whether using a patient's own blood product (L-PRF) can improve bone healing after surgery for a persistent tooth-root infection. Fifteen adults with large infections around the tooth root were treated and followed for 12 months. The goal was to see if adding…

This study looked at whether a root canal for an infected tooth with an abscess can be done in one visit instead of two. Fifty-nine adults received either a single-visit treatment or a two-visit treatment with a calcium hydroxide medication placed in between. After 12 months, bot…

This small pilot study tested a new way to treat dead (necrotic) teeth in 6 adults. Doctors took pulp tissue from a healthy donor tooth, mixed it with a growth factor concentrate (CGF), and transplanted it into the dead tooth. After 12 months, they checked if the tooth regained f…

This study tested three different materials (blood clot, platelet-rich fibrin, and concentrated growth factor) combined with two types of rinses to help regrow root tissue in 30 immature permanent teeth with dead nerves. Participants aged 9 to 25 were followed for 12 months using…

This study tested whether placing a thin bone layer (cortical lamina) over the extraction site helps preserve the jawbone's shape and size. Forty adults needing a tooth pulled were randomly assigned to get the lamina or standard care. After six months, bone changes were measured …

This study tested whether natural gels (curcumin and nanocurcumin) or synthetic gels (ciprofloxacin with ibuprofen) placed inside a tooth between retreatment visits can help heal infections better than the standard calcium hydroxide paste. Sixty adults with failed root canals and…

This study evaluates how accurately the Root ZX3 electronic apex locator measures the working length of root canals in single-rooted teeth that need to be extracted. Researchers compare the device's measurements with microscopic measurements taken after extraction, which serve as…

Researchers at Ain Shams University are testing whether aloe vera gel, placed inside a tooth after root canal cleaning, reduces inflammation and pain better than the standard calcium hydroxide dressing. The trial enrolls 33 adults with dead or dying teeth and infection around the…

This study tested a more precise dental surgery for people with persistent root infections after standard treatment. Using a 3D-printed guide, surgeons aimed to remove infected tissue more accurately, reduce surgery time, and improve quality of life. The trial involved 70 adults …

This study tested whether rinsing the tooth with cold saline (cryotherapy) or placing metformin (a diabetes drug) inside the tooth can reduce pain after root canal treatment. 80 adults with infected lower premolars were randomly assigned to receive one of four treatments. Pain wa…

This study tests whether a simple technique called apical patency—passing a tiny file slightly beyond the root tip during root canal treatment—can reduce pain afterward. Adults with an infected front tooth will be randomly assigned to receive treatment with or without this extra …

This trial asks whether photobiomodulation — a type of low-level laser therapy — can lessen pain and swelling after endodontic (root-end) surgery. Thirty-four adults needing surgery on an upper tooth will be randomly assigned to receive either the laser treatment or a sham proced…

This trial compares two irrigation solutions used during regenerative endodontic treatment for immature permanent teeth with infection. Forty children aged 9 to 16 will receive either octenidine or EDTA as a rinse, and their pain levels will be tracked for a week. The goal is to …

This study tests whether using cooled liquid to clean the inside of a tooth during root canal treatment can reduce pain afterward. It includes adults with certain tooth conditions who need a root canal. The approach involves comparing cooled versus room-temperature irrigation to …

This trial tests whether a corticosteroid injection given before root canal treatment can reduce pain and inflammation afterward. One hundred adults with symptomatic pulpitis (tooth nerve inflammation) are randomly assigned to receive either standard root canal treatment alone or…

This study looks at whether people with diabetes experience more pain after a second root canal treatment compared to those without diabetes. About 50 adults with a single-rooted tooth needing retreatment will take part. Pain levels and painkiller use will be tracked for a week a…

This study tested whether using special lasers during root canal treatment can lower pain afterward compared to standard methods. Forty-five adults with infected front teeth were split into three groups: one got standard cleaning, another got a combination of two lasers, and the …

This study tested whether using different modes on an electronic apex locator (a tool that measures tooth canal length) during root canal retreatment could reduce pain afterward. 144 adults with infected teeth were split into four groups: one used a standard locator, and three us…

This study tested a device called EDDY that uses sound waves to clean root canals better. Forty adults with infected teeth but no pain were treated. The sonic cleaning killed more bacteria than standard methods, but it did not reduce pain after the procedure compared to usual car…

This study tested whether applying cold therapy (cryotherapy) inside the mouth or inside the tooth itself can reduce pain and inflammation after root canal treatment. Thirty adults with painful tooth infections received either an oral cold pack, a cold saline rinse inside the too…

This study tested a procedure called full pulpotomy (removing only the infected pulp inside the tooth crown) in 58 adults with severe toothache. It compared success in teeth with and without an infection at the root tip (apical periodontitis), using an AI tool to help detect the …

This study looked at three different root canal sealers to see if any caused less pain or helped teeth heal faster. Seventy-two adults with infected single-rooted teeth received standard root canal treatment with one of the sealers. Pain was checked right after, at 24 hours, and …

This study looked at whether using sonic irrigation or a diode laser during root canal treatment reduces pain afterward. Eighty adults with infected single-rooted teeth were randomly assigned to one of four cleaning methods. Patients reported their pain levels and painkiller use …

This study tested two different materials—surgical glue and ferric sulfate—to control bleeding during root-end surgery in 34 patients with infected tooth roots. Researchers measured how well each agent stopped bleeding, how much pain patients felt afterward, and their quality of …

This study looked at five different methods for cleaning infected root canals in 132 people with large tooth infections. The goal was to see which technique helps the infection heal best by reducing the size of the infection site on X-rays. The methods included manual cleaning, u…

This study looked at 42 adults with infected single-rooted teeth to see if using sonic or ultrasonic tools to clean the root canal helps the tooth heal better than the standard method. Participants got one of three cleaning techniques during their root canal, and the size of the …

This study looked at 120 adults needing a root canal to see if one sealer (AH Plus or WellRootST) causes less pain afterward. Pain was checked before treatment and at several points up to one month later. The goal is to help dentists choose the better option for patient comfort.

This study tested whether using 3D-guided microsurgery helps bone heal better after a failed root canal compared to standard surgery. It also compared two different filling materials: a newer bioceramic putty and the standard MTA. Twenty-four adults with persistent infections aft…

This study tested whether using a sonic device (EndoActivator) to clean the tooth during a root canal reduces pain afterward. Fifty-eight adults with tooth infections were randomly assigned to get either the sonic cleaning or standard syringe irrigation. Pain was measured before …

This study tested whether a rinse called octenidine reduces pain after root canal treatment better than the standard rinse chlorhexidine. 142 adults with a single-rooted tooth and asymptomatic apical periodontitis received one of the two rinses during their procedure. Pain was re…

This pilot study looked at bacteria in root canal infections, comparing painful and painless cases. Researchers used DNA testing to identify bacteria before and after cleaning with two different strengths of sodium hypochlorite. The goal was to see how well the cleaning removes b…

This study looked at 120 adults to see if anxiety and depression are linked to a common tooth infection called apical periodontitis. Participants had dental exams and filled out questionnaires about their mental health. The goal was to better understand how emotional well-being a…

This study looked at whether injecting a substance made from a patient's own blood (injectable platelet-rich fibrin, or i-PRF) could help heal teeth with chronic infection at the root. Sixty adults with infected teeth received standard root canal treatment; half also got the i-PR…

This study looked at 185 people to compare inflammation markers in those with tooth infections (apical periodontitis), gum disease (chronic periodontitis), and healthy gums. Researchers measured substances like TNF-α and PGE2 in blood and gum fluid. The goal was to better underst…

This completed study measured two immune proteins, IL-8 and IL-10, in fluid from the gums and around the tooth root during root canal treatment. Researchers wanted to see how these levels change as treatment progresses in people with infected, dead tooth pulp. Twenty-two adults a…

This study looked at whether a common jaw joint disorder (anterior disc displacement with reduction) affects pain after root canal treatment. 70 adults with tooth infection and jaw pain were treated and tracked their pain for a week. The goal is to see if dentists should consider…

This study looked at whether treating a chronic tooth infection (apical periodontitis) can reduce inflammation and improve the health of blood vessel walls. Researchers measured inflammatory markers and blood vessel barrier proteins in 45 healthy adults aged 25-55, both with and …

This study looked at whether using a special laser (Nd:YAG) during root canal treatment could help reduce inflammation and oxidative stress in infected teeth. Researchers measured certain markers in fluid samples from 58 patients. The results showed that the laser did not provide…