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New guided surgery technique could improve healing after failed root canals

NCT ID NCT07184151

Symptom relief Sponsor: Suez Canal University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether using 3D-guided microsurgery helps bone heal better after a failed root canal compared to standard surgery. It also compared two different filling materials: a newer bioceramic putty and the standard MTA. Twenty-four adults with persistent infections after root canal treatment were randomly assigned to one of four groups. The researchers measured operating time, bone density changes, and pain levels over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Well root putty (bioceramic putty) and MTA (mineral trioxide aggregate) as retrograde filling materials
What this could lead to
If successful, this could show that guided microsurgery and newer filling materials improve bone healing and reduce pain after failed root canal treatment.
What could go wrong
This is a small, early-stage trial with only 24 participants, so results may not apply to everyone. The outcomes focus on short-term measures like operating time and pain, not long-term success.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

24 people

The number who actually took part.

Started

Jan 2022

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Tooth is restorable pocket depth is less than 4mm and mobility in its normal limit ( less than 1mm) * Persisting or emerging disease following root-canal treatment when root canal re-treatment is inappropriate. * Tooth with acceptable endodontic treatment and have a new post and crown restoration, but have a persistent or enlarging periapical lesion ( size less than 10 mm) * Obstructed canal (the obstruction proved not to be removable, by passed and the risk of damage was too great). * Extruded material or instrument with clinical or radiological findings of apical periodontitis and/or symptoms are present. Exclusion Criteria: * Non restorable tooth * Contraindicating medical condition ( severe systemic condition and psychological condition) * Anatomical contra indication * Poor general oral status and supporting periodontal tissue.

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endodontic re-treatment failure

Contacts and locations

Locations

  • Faculty of Dentistry, Suez Canal University

    Ismailia, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.