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Glue or chemical? study tests best way to stop bleeding after tooth surgery

NCT ID NCT07311291

Symptom relief Sponsor: University of Turin, Italy Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two different materials—surgical glue and ferric sulfate—to control bleeding during root-end surgery in 34 patients with infected tooth roots. Researchers measured how well each agent stopped bleeding, how much pain patients felt afterward, and their quality of life for a week. The goal is to find which option leads to a smoother recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
surgical glue and ferric sulfate
What this could lead to
If successful, this could help dentists choose a better hemostatic agent to reduce pain and improve recovery after root-end surgery.
What could go wrong
This is a small, completed trial with only 34 participants, so results may not apply to everyone. The study does not test long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

34 people

The number who actually took part.

Started

Feb 2025

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Consecutive informed and consenting healthy subjects (ASA 1-2) of both genders with no medical history of systemic disease and presenting a diagnosis of symptomatic or asymptomatic apical periodontitis in correspondence of endodontically treated teeth with medium (2-5 mm3) and large (≥5 mm3) periapical lesions. * Subjects with periapical defects with one or two residual cortical walls. * Subjects with clinical indications for retrograde endodontic retreatment: teeth presenting inadequate root canal treatment with periapical radiolucency and impossible access through orthograde retreatment due to the presence of prosthetic restorations, posts, canal blocks and ledges. * Subjects with teeth presenting an adequate coronal seal and absence of pathological periodontal records. Exclusion Criteria: * Subjects affected by diabetes mellitus. * Subjects affected by hypertension. * Subjects affected by hepatic or renal diseases. * Subjects affected by bleeding disorders, antiplatelet or anticoagulant therapy. * Women experiencing pregnancy. * Subjects with teeth considered not restorable. * Subjects with dental elements affected by fractures. * Subjects with dental elements affected by extensive periodontal defects. * Subjects with bone cavity designs with no residual cortical walls.

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Conditions

The condition(s) this trial relates to.

dental pulp disorder Periapical Diseases periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endodontic infection Periapical diseases

Contacts and locations

Locations

  • Dental School

    Torino, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.