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Blood injection may boost tooth infection healing

NCT ID NCT07320898

Knowledge-focused Sponsor: Kırıkkale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether injecting a substance made from a patient's own blood (injectable platelet-rich fibrin, or i-PRF) could help heal teeth with chronic infection at the root. Sixty adults with infected teeth received standard root canal treatment; half also got the i-PRF injection. Researchers measured two enzymes in fluid around the tooth to see if the injection changed healing activity. The goal was to understand if i-PRF might improve recovery, not to test a cure or symptom relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

60 people

The number who actually took part.

Started

Jan 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients between the ages of 18-64 years old and diagnosed with apical periodontitis who applied to Kırıkkale University, Faculty of Dentistry, Department of Endodontics with the indication of root canal treatment will be included in the study.

Ages

18 to 64 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Sixty patients who applied to Kırıkkale University Faculty of Dentistry and were diagnosed with chronic apical periodontitis and were included in the PAI 3-4 groups according to the Periapical Index Scoring System (PAI) among the patients who were prescribed root canal treatment were included in the study. * Patients aged 18-64 * Upper or lower incisors and premolars with primary apical periodontitis * Patients with ASA I * Patients who have provided written informed consent to participate in the study. Exclusion Criteria: * Patients with ASA II or higher, * Patients who have used antibiotics and anti-inflammatory medications within the last month, * Patients with a periodontal pocket greater than 3 mm in the affected tooth, * Teeth with internal or external root resorption, or teeth with swelling and pain on palpation, * Pregnant women or those suspected of pregnancy, * Patients with generalized periodontitis, * Patients with immunosuppressive systemic diseases such as diabetes and hepatitis will not be included in the study.

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alkaline phosphatase Apical periodontitis Biomarkers I-PRF MMP-9

Contacts and locations

Locations

  • Kırıkkale University, Faculty of Dentistry

    Kirikkale, Kırıkkale, 71100, Turkey (Türkiye)

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