Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Root canal may lower inflammation and protect arteries, study suggests

NCT ID NCT07292363

Knowledge-focused Sponsor: University of Turin, Italy Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether treating a chronic tooth infection (apical periodontitis) can reduce inflammation and improve the health of blood vessel walls. Researchers measured inflammatory markers and blood vessel barrier proteins in 45 healthy adults aged 25-55, both with and without tooth infections, before treatment and again 6 and 12 months after root canal therapy. The goal is to see if treating the infection can lower inflammation and help prevent blood vessel damage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
endodontic treatment (root canal therapy)
What this could lead to
If successful, this study could show that treating a tooth infection helps reduce inflammation and protect blood vessel health.
What could go wrong
This is a small, completed observational study with only 45 participants. It does not test a new treatment and cannot prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

45 people

The number who actually took part.

Started

Feb 2021

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Dental Hospital

Ages

25 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 25-55 years * in general health * with or without endodontic disease Exclusion Criteria: * under 25 years * over 55 years * subjects with systemic or oral diseases other than endodontic affections * patients who underwent other dental treatments in the previous 6 months

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Apical periodontitis are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

chronic apical periodontitis Inflammation periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis Healhty

Contacts and locations

Locations

  • Department of Oncology - University of Turin

    Turin, Italy, 10126, Italy

  • Endodontics, Department of Surgical Sciences - Univeristy of Turin

    Turin, Italy, 10126, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.