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Can turmeric gels beat standard tooth infection treatments?

NCT ID NCT06342830

Disease control Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether natural gels (curcumin and nanocurcumin) or synthetic gels (ciprofloxacin with ibuprofen) placed inside a tooth between retreatment visits can help heal infections better than the standard calcium hydroxide paste. Sixty adults with failed root canals and persistent infections participated. The main goal was to see if the infection site shrank on a 3D X-ray after one year.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

60 people

The number who actually took part.

Started

Jun 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Medically free Patients * both sex includes male and females * Patients age between 20-60 * Patients agreement positively to share in the study * patient able to sign informed consent * on clinical and radiographic examinations, the included teeth maxillary and mandibular single root canal anteriors or premolars suffering from failed endodontic treatment with periapical lesion Exclusion Criteria: * badly broken down teeth indicated for extraction or with difficult isolation * teeth with former procedural errors as ledge, perforation or instrument separation * Medically compromised patients * patients with history of receiving antibiotics within a month before starting study * periodontally affected teeth by pocket depth \& \> 4mm

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Conditions

The condition(s) this trial relates to.

Periapical Diseases periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periapical disease

Contacts and locations

Locations

  • faculty of dentistry, Ain shams university

    Cairo, 11512, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.