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Tooth infection showdown: which filling material heals better?

NCT ID NCT07246512

Disease control Sponsor: University of Valencia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This study compares two materials used to seal the tip of a tooth root during surgery for persistent infections after root canal treatment. About 110 adults will receive either MTA or TotalFill BC-RRM Fast Set Putty. Researchers will check healing with 3D X-rays after one year to see which material works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Mineral Trioxide Aggregate (MTA) and BioCeramic Root Repair Material (TotalFill BC-RRM Fast Set Putty)
What this could lead to
If one material proves more effective, it could improve healing rates for persistent tooth infections after root canal treatment.
What could go wrong
This is a small, early-stage trial with only 110 patients and no blinding, so results may not be conclusive or widely applicable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

110 people

The number who actually took part.

Started

Feb 2024

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients over 18 years of age. * Patients giving consent for surgical intervention, for radiographic evaluation with HCT preoperatively and at least one more time after 12 months, and for participation in the study. * Medical history not relevant to the diagnosis and surgical treatment (ASA classes I and II). * Previous non-surgical endodontic treatment or retreatment with clinical and/or radiographic evidence of persistence or recurrence of apical periodontitis. The minimum time since the last non-surgical treatment shall be 6 months. * Teeth not previously treated with periapical surgery. * Lesion less than 10 mm in diameter. * Restorable teeth. * Periodontally sound teeth or teeth with treated periodontal pathology (mobility 1, probing depth \< 5mm). * Teeth with no root resorption. Exclusion Criteria: * Teeth with vertical fracture. * Teeth with root perforation. * Lesions associated with an apicomarginal defect. * Tunnel lesions. * Technical errors during surgery that may compromise the outcome. * Lack of integrity of the dentine walls surrounding the retrograde filling detected with the endoscope. * Wound dehiscence. * Postoperative infection. * Follow-up less than 12 months.

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Conditions

The condition(s) this trial relates to.

periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periapical lesion

Contacts and locations

Locations

  • University of Valencia

    Valencia, 46010, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.