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Root canal pain relief: sonic and laser methods show no advantage

NCT ID NCT07170098

Symptom relief Sponsor: Biruni University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether using sonic irrigation or a diode laser during root canal treatment reduces pain afterward. Eighty adults with infected single-rooted teeth were randomly assigned to one of four cleaning methods. Patients reported their pain levels and painkiller use over a week. The results showed no significant difference in pain or medication use between any of the methods.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
EDDY sonic irrigation system, EndoActivator sonic irrigation system, 980-nm diode laser
What this could lead to
If successful, this could help dentists choose the best method to reduce pain after root canal treatment.
What could go wrong
The trial was small (80 people) and already completed, showing no difference between methods. Results may not apply to other tooth types or more severe infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

80 people

The number who actually took part.

Started

Aug 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Medically healthy adult patients aged 18-65 years * Patients diagnosed with asymptomatic apical periodontitis in permanent single-rooted teeth with closed apices and radiographic PAI score of 3 or 4 * Healthy periodontal conditions Exclusion Criteria: * Pregnant women * Patients with systemic disorders * Teeth with open apex, prosthetic restorations, mobility \> grade I, periodontal pocket depth \> 4 mm, non-restorable condition, calcified root canals, resorption, traumatic occlusion, or history of previous endodontic treatment * Patients who had taken analgesics within 12 hours prior to intervention * Patients who had received antibiotic therapy within the past month

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Conditions

The condition(s) this trial relates to.

Asymptomatic Infections Pain, Postoperative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis Asymptomatic infections Post operative pain

Contacts and locations

Locations

  • Biruni University

    Istanbul, 34010, Turkey (Türkiye)

More trials for these conditions

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