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New tooth-cleaning methods could speed healing of serious infections

NCT ID NCT06991803

Symptom relief Sponsor: Recep Tayyip Erdogan University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at five different methods for cleaning infected root canals in 132 people with large tooth infections. The goal was to see which technique helps the infection heal best by reducing the size of the infection site on X-rays. The methods included manual cleaning, ultrasound, sonic vibration, and two types of laser activation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

132 people

The number who actually took part.

Started

Jun 2023

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients aged 18 years and over * Patients who approved the Endodontic Consent Form and Study Participation Form * Vertucci Class 1 single-rooted mandibular premolars with PAI score of 3 and above, requiring primary endodontic treatment with a diagnosis of apical periodontitis * Vertucci Class 1 single-rooted mandibular premolars with PAI score of 3 and above, requiring retreatment with a diagnosis of apical periodontitis * Patients with good oral hygiene Exclusion Criteria: Patients with systemic diseases * Immunosuppressive patients * Pregnant patients * Those with mobility of 2 and above, * Those with periodontal pocket depth of 5 mm and above. * Those with internal and external resorption, * Those with teeth with vertical and horizontal root fractures

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Conditions

The condition(s) this trial relates to.

periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Irrigation activation LASERS Periapical periodontitis

Contacts and locations

Locations

  • Recep Tayyip Erdoğan University Faculty of Dentistry Department of Endodontics

    Rize, Rize Province, 53020, Turkey (Türkiye)

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