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Ice pack or cold rinse: simple trick to beat root canal pain?

NCT ID NCT07138365

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether applying cold therapy (cryotherapy) inside the mouth or inside the tooth itself can reduce pain and inflammation after root canal treatment. Thirty adults with painful tooth infections received either an oral cold pack, a cold saline rinse inside the tooth, or standard care. Researchers measured pain levels and a chemical linked to inflammation. The goal is to find a simple, drug-free way to manage post-treatment discomfort.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cryotherapy (cold packs or cold saline irrigation)
What this could lead to
If it works, this could offer a simple, drug-free way to manage pain after root canal treatment.
What could go wrong
This is a small, early-stage study with only 30 participants, so results may not apply to everyone. The effect may be small or no better than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

180 people

The number who actually took part.

Started

Jun 2024

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Both genders 2. Eligible participants will be between the ages of 18-45 3. Participants willing to commit for the entire period of the trial and agreed to sign the written consent after full explanation of the study 4. Having a mandibular single rooted premolar tooth with vital pulp Vertucci Type I canal system. 5. Patients that will be diagnosed with symptomatic apical periodontitis on the basis of the clinical symptoms of severe preoperative pain (visual analogue scale \[VAS\] \> 7) and severe percussion pain (VAS \> 7) 6. The absence of periapical radiolucency on x ray. Exclusion criteria : 1. Presence of any systemic disease or allergic reactions 2. Vulnerable population: prisoners, pregnant women, mentally ill people, etc. 3. Use of analgesic or antibiotic medication within seven days 4. A radiographically untraceable canal 5. Excessively curved root 6. Excessively long or short root length 7. Teeth with open apices 8. A previous root canal treatment 9. Sinus tracts 10. Local gum swelling around the affected tooth 11. Severe periodontal disease 12. Presence of periodontal pockets \>3 mm in the affected tooth 13. Absence of bleeding in the pulp chamber on access cavity preparation 14. Problems in determining working length 15. Broken files, over instrumentation, and overfilling/incomplete filling

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Conditions

The condition(s) this trial relates to.

Inflammation inflammatory disease Pain, Postoperative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Inflammation Post operative pain

Contacts and locations

Locations

  • Ain Shams University

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.